Helicobacter pylori seropositivity in patients with hyperemesis gravidarum

Abstract

HP infection seemed to be significantly associated with hyperemesis gravidarum in our pregnant patient population with hyperemesis gravidarum.

Helicobacter Pylori Stool Antigen Assay in Hyperemesis Gravidarum: A Risk Factor for Hyperemesis Gravidarum or Not?

“…Despite the numerous explanatory hypotheses, including endocrinological, psychological, metabolic, and anatomical causes assumed to be responsible for HG, none is completely satisfactory [5]. Recent publications emphasized on the possible association between H. pylori infection and HG [7][8][9][10][11]. As a gram-negative flagellated spiral bacterium, H. pylori colonizes stomach and creates the basis of pathogenesis of numerous gastric pathologies, including chronic gastritis, duodenal and gastric ulcers, and some types of gastric cancer and lymphoma [7][8][9][10][11][12][13].…”

“…Recent publications emphasized on the possible association between H. pylori infection and HG [7][8][9][10][11]. As a gram-negative flagellated spiral bacterium, H. pylori colonizes stomach and creates the basis of pathogenesis of numerous gastric pathologies, including chronic gastritis, duodenal and gastric ulcers, and some types of gastric cancer and lymphoma [7][8][9][10][11][12][13]. Several reports indicating on the causal relationship between H. pylori infection and HG share the suggestion made by Frigo et al, namely, in the early phase of pregnancy, as a result of the increase in steroid hormones, fluid accumulation, and a displacement of intracellular and extracellular volume occur, which in turn leads to change on gastric pH level.…”

“…According to this hypothetical mechanism, a latent H. pylori infection might become a manifest one [13]. Another point shared collectively by all these studies is the detection of H. pylori infection by serologic assay [7][8][9][10][11]. A more recent Turkish study used both serologic and HpSA testing to investigate the infectious status of the HG patients.…”

“…More recently, some studies performed on patients with HG indicated on causative relationship between H. pylori infection and HG [7,8]. However, there is no study that investigates the relationship between HG and the H. pylori stool antigen positivity.…”

Association Between Helicobacter pylori Infection in Mothers and Birth Weight

“…At present, association between H. pylori and small stature remains to be confirmed. Recently, an association between H. pylori infection and morning sickness [6,7], as well as intrauterine growth restriction, has also been suggested [8].…”