Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy

Gülçelik, Neşe Ersöz; Kaya, Emın; Demirbaş, Berrin; Culha, Cavit; Koç, Gönül; Özkaya, Murat; Çakal, Erman; Serter, Rüştü; Aral, Yalcin

doi:10.1007/bf03345375

Cited by 65 publications

(79 citation statements)

References 19 publications

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“…Again, the HbA1c values did not differ between Hp-negative and Hppositive patients in the study conducted by Gulcelik et al on 75 diabetic patients [11]. The study conducted on 63 Chinese diabetic patients by Gray et al also supported these two studies [12].…”

Section: Resultsmentioning

confidence: 64%

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Böyük¹,

Kilicaslan²,

Çelebi³

et al. 2017

J Gastrointest Dig Syst

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Aim: Helicobacter pylori (Hp) is the causative agent of the most common chronic infection in the world. The close association of Hp with gastric and duodenal ulcer, gastric cancer and MALToma has been proven. Besides, there are numerous studies reporting the coexistence of Hp with diabetes mellitus, coronary artery disease, idiopathic thrombocytopenic purpura, and iron deficiency anemia. Material-Methods:This study was conducted on 205 diabetic patients including 75 male and 130 female individual with dyspeptic complaints. The endoscopic biopsy specimens of these patients were investigated for the presence of Hp. Also, histochemical examinations were carried out. The patients were divided into two groups, namely, Hp-positive and Hp -negative group. The Helicobacter pylori positive group was divided into three subgroups as follows based on their bacterial intensity: Hp density-1, Hp density-2, Hp density-3 groups to compare metabolic parameters between subgroups.Results: A total of 205 diabetic patients enrolled in the study. The mean HbA1c levels of the patients without Hp was 7.59 ± 1.66 while that of the patients with Hp was found to be 7.57 ± 1.77. No statistically significant difference was detected between these two groups. Likewise, no statistically significant difference was observed in terms of HbA1c levels among the groups when they were classified according to Hp density. Conclusion:In this study, we investigated metabolic outcomes of the coexistence of two commonly occurring entities, a chronic infection and a chronic disease. No relationship was detected regarding the presence of Helicobacter pylori and its intensity with the metabolic parameters mainly the HbA1c levels of diabetic people.

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Section: Resultsmentioning

confidence: 64%

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Böyük¹,

Kilicaslan²,

Çelebi³

et al. 2017

J Gastrointest Dig Syst

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“…Sherwal, et al [4] and Taher, et al [14], also observed higher prevalence of H. pylori in diabetic dyspeptic patients than in non-diabetic. Many other authors across the world including Ali and Sarkis [1], Kimiaki, et al [15], Oldenburg, et al [9] Quadri, et al [16] Gulcelik, et al [17] have also observed statistically significant association of H. pylori with diabetes mellitus. Several reasons have been advanced as to the increased susceptibility to infection in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

J Clin Gastroenterol Treat

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Introduction: Infection to Helicobacter pylori has been associated to many gastrointestinal diseases including gastritis, peptic ulcer disease, gastroesophageal reflux disease, atrophic gastritis and gastric cancer. Chronic infections are frequent and severe in patients with diabetes mellitus (DMT2), probably due to the impairment of their immune status. The link between H. pylori infection and diabetes mellitus (DM) remains controversial. This study aimed at detection and comparison of anti H. pylori antibodies (IgG) in serum of diabetes mellitus type 2 (DMT2) and non-diabetic dyspepsia subjects and also to find if there exists any significant correlation between H. pylori infection and DMT2.

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“…However, it is interesting to note that in humans, the association between H. pylori infection and type 2 diabetes remains controversial (Dore et al, 2000;Gillum, 2004;Gulcelik et al, 2005;Ko et al, 2001;Quadri et al, 2000). There is additional evidence for the occurrence of pancreatic disease in the context of H. pylori infection (Manes et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis

García

Dewhirst³

et al. 2006

Journal of Medical Microbiology

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Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy

Cited by 65 publications

References 19 publications

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

Dyspeptic Symptoms in Patients with Type 2 Diabetes Mellitus: Helicobacter pylori Infection and Its Associations with Metabolic Control

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Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis

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