Helicobacter pylori-Negative Primary Rectal MALT Lymphoma: Complete Remission after Radiotherapy

Okamura, Takuma; Suga, Tomoaki; Iwaya, Yugo; Ito, Tetsuya; Yokosawa, Shuichi; Arakura, Norikazu; Ota, Hiroyoshi; Tanaka, Eiji

doi:10.1159/000339461

Cited by 15 publications

(11 citation statements)

References 13 publications

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“…There are case reports describing successful treatment of colorectal lymphoma with radiation only, surgical resection, or endoscopic mucosal resection. 80,[83][84][85] Management of localized lesions depends on depths and size of lesion. Small, shallow lesions may be amenable to endoscopic submucosal resection.…”

Section: Mucosa-associated Lymphoid Tissuementioning

confidence: 99%

Colorectal Lymphoma: A Review

Chen

Okada

2018

Clinics in Colon and Rectal Surgery

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Non-Hodgkin lymphoma (NHL) that primarily involves the colon is rare and should be distinguished from the more common systemic nodal lymphoma. It has unique clinical expectations and management consideration. Different histologic subtypes of NHL involve the colon, which varies in the clinical behavior and likelihood of obtaining durable remissions with treatment. This article will review the current understanding of the different histologic subtypes of primary colorectal lymphoma and propose management algorithms.

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Section: Mucosa-associated Lymphoid Tissuementioning

confidence: 99%

Colorectal Lymphoma: A Review

Chen

Okada

2018

Clinics in Colon and Rectal Surgery

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“…Besides, radiotherapy is also effective. Okamura et al [ 20 ] reported that three stage I cases achieved complete remission by radiotherapy. This clinical effect was also confirmed in case reports of Amouri et al [ 21 ], Foo et al [ 22 ], and Hayakawa et al [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Laterally spreading tumor-like primary rectal mucosa-associated lymphoid tissue lymphoma: A case report

Wei¹,

Min²,

Ren³

et al. 2021

WJCC

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BACKGROUND Colorectal mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease, and only a few cases have been reported to date. It has no specific clinical presentations and shows various endoscopic appearances. There is no uniform consensus on its treatment. With the advancement of endoscopic technology, endoscopic treatment has achieved better results in individual case reports of early-stage patients. CASE SUMMARY We report a case of rectal MALT in a 57-year-old Chinese man with no symptoms who received endoscopy as part of a routine physical examination, which incidentally found a 25 mm × 20 mm, laterally spreading tumor (LST)-like elevated lesion in the rectum. Therefore, he was referred to our hospital for further endoscopic treatment. Complete and curable removal of the tumor was performed by endoscopic submucosal dissection. We observed enlarged and dilated branch-like vessels similar to those of gastric MALT lymphoma on magnifying endoscopy with narrow-band imaging. And immunopathological staining showed hyperplastic capillaries in the mucosa. Histopathological findings revealed diffusely hyperplastic lymphoid tissue in the lamina propria, with a visible lymphoid follicle structure surrounded by a large number of diffusely infiltrated lymphoid cells that had a relatively simple morphology and clear cytoplasm. In addition, immunohistochemical analysis suggested strongly positive expression for CD20 and Bcl-2. Gene rearrangement results showed positivity for IGH-A, IGH-C, IGK-B, and IGL. Taking all the above findings together, we arrived at a diagnosis of extranodal marginal zone B-cell lymphoma of MALT lymphoma. Positron emission tomography-computed tomography examination showed no other lesions involved. The patient will be followed by periodic endoscopic observation. CONCLUSION In conclusion, we report a case of rectal MALT with an LST-like appearance treated by endoscopic submucosal dissection. Further studies will be needed to explore the clinical behavior, endoscopic appearance, and treatment of rectal MALT.

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“… 2 , 13–15,18 MALT lymphoma is often treated with a rituximab-based regimen such as R-CHOP and radiotherapy to achieve complete remission without major complications. 15 , 16…”

Section: Discussionmentioning

confidence: 99%

Mucosa-Associated Lymphoid Tissue Lymphoma of the Sigmoid Colon Discovered on Routine Screening Colonoscopy in Patient with Hepatitis C and Helicobacter pylori Infection

Bhuta

Bromberg

Bains

et al. 2016

ACG Case Reports Journal

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Mucosa-associated lymphoid tissue (MALT) lymphoma is predominantly found in the stomach. Rarely, it is found in the proximal colon and even less so in the sigmoid colon. We present a rare case of primary sigmoid colon MALT lymphoma in a patient with concomitant Helicobacter pylori and hepatitis C infection. We also review current imaging, staging, and therapeutic modalities. To our knowledge, this is the first sigmoid colon MALT lymphoma reported in the United States.

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Helicobacter pylori-Negative Primary Rectal MALT Lymphoma: Complete Remission after Radiotherapy

Cited by 15 publications

References 13 publications

Colorectal Lymphoma: A Review

Colorectal Lymphoma: A Review

Laterally spreading tumor-like primary rectal mucosa-associated lymphoid tissue lymphoma: A case report

Mucosa-Associated Lymphoid Tissue Lymphoma of the Sigmoid Colon Discovered on Routine Screening Colonoscopy in Patient with Hepatitis C and Helicobacter pylori Infection

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