Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

Abstract

Epidemiologic and clinical data suggest that Helicobacter pylori infection is a contributing factor in the progression of atherosclerosis. However, the specific cardiovascular disease risk factors associated with H. pylori remain unclear. We performed a cross-sectional study of 37,263 consecutive healthy subjects who underwent a routine health check-up. In multivariable log Poisson regression models adjusted for potential confounders, the associations of H. pylori seropositivity with higher LDL-C (relative risk [RR], 1.21; 95% confidence interval [CI], 1.12–1.30) and lower HDL-C level (RR, 1.10; 95% CI, 1.01–1.18) were significant and independent. In multiple linear regression analyses, H. pylori infection was significantly associated with higher total cholesterol level (coefficient = 2.114, P < 0.001), higher LDL-C level (coefficient = 3.339, P < 0.001), lower HDL-C level (coefficient = −1.237, P < 0.001), and higher diastolic blood pressure (coefficient = 0.539, P = 0.001). In contrast, H. pylori infection was not associated with obesity-related parameters (body mass index, waist circumference), glucose tolerance (fasting glucose, glycated hemoglobin), and systolic blood pressure. We found that H. pylori infection was significantly and independently associated with dyslipidemia, but not with other cardiometabolic risk factors, after adjusting for potential risk factors of atherosclerosis.

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

“…The association of H. pylori infection with lipid profile changes was observed earlier in 1996 in Finnish subjects, their serum cholesterol and TG levels were significantly higher in H. pylori-infected male persons after adjustment of age and BMI (Buzas et al 2014). More recently, Kim et al (2016) have found that subjects with H. pylori infection had higher total cholesterol and LDL-C, as well as lower HDL-C. They explained that alterations of lipid profile may be mediated by inflammatory cytokines such as IL-1, IL-6, or tumor necrosis factor-α (TNF-α) through a chronic inflammatory condition induce by H. pylori.…”

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

“…Following the aforementioned initial reports, there have been amounting data from observational studies (mostly cross‐sectional) having evaluated the potential association between H pylori ‐I and NAFLD . The main characteristics and results of these studies are summarized in Table .…”

“…Following the aforementioned initial reports, there have been amounting data from observational studies (mostly cross-sectional) having evaluated the potential association between H pylori-I and NAFLD. [19][20][21][22][23][24][25][26][27][28][29][30][31][32] The main characteristics and results of these studies are summarized in Table 1. The majority of them (n = 12) have been carried out in Asia (China, South Korea, Japan, and Turkey), two in Europe (Greece and Spain), and one in the USA.…”

Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma—author's reply

“…However, the multivariable analysis-adjusted potential confounding factors showed that H. pylori infection was not associated with fasting blood glucose or HbA1c. 3 The association between H. pylori infection and diabetes mellitus and glucose intolerance remains controversial. A meta-analysis of 41 studies revealed a higher prevalence rate of H. pylori in diabetic patients than in nondiabetic patients.…”

“…Recently, we investigated the association between H. pylori infection and each component of metabolic syndrome. 3 The study included 37 263 asymptomatic men and women undergoing a routine health check-up and found that the levels of fasting blood glucose and glycated hemoglobin (HbA1c) were significantly higher in participants with H. pylori infection. Also, diabetes mellitus was more prevalent in individuals with H. pylori.…”