Helicobacter Pylori Infection Is Not Associated With Diabetes Mellitus, Nor With Upper Gastrointestinal Symptoms in Diabetes Mellitus

Xia, Harry Hua‐Xiang; Talley, Nicholas J.; Kam, Elisa; Young, Lisa J.; Hammer, Johann; Horowitz, Michael

doi:10.1111/j.1572-0241.2001.03604.x

Cited by 94 publications

(81 citation statements)

References 32 publications

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“…Results presented here indicate that H. pylori infection is not related to the presence of dyspeptic symptoms, confirming recent literature data (8,21). The infection was found in 34.4% of the patients, similar to another Brazilian study with DM1 adolescent patients (22).…”

Section: Discussionsupporting

confidence: 79%

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Faria

Pavin

Parisi

et al. 2015

Arch. Endocrinol. Metab.

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Objectives: To evaluate, in a group of patients with long-standing type 1 diabetes (DM1), an association of dyspepsia symptoms with: changes in the gastroduodenal mucosa, infection by Helicobacter pylori, glycemic control, and psychological and nutritional factors. Subjects and methods: A total of 32 patient with DM1 were studied (age: 38 ± 9 years; females: 25; diabetes duration: 22 ± 5 years). All patients answered a standardized questionnaire for the evaluation of gastrointestinal symptoms and underwent upper gastrointestinal endoscopy, with gastric biopsies for the evaluation of Helicobacter pylori infection. The presence of anxiety and depression was evaluated by the HAD scale. Nutritional parameters were BMI, arm and waist circumference, skinfold measurement, and body fat percentage. Results: Upper endoscopy detected lesions in the gastric mucosa in 34.4% of the patients, with similar frequency in those with (n = 21) and without dyspepsia (n = 11). The patients with dyspepsia complaints showed greater frequency of depression (60% vs. 0%; p = 0.001), higher values for HbA1c (9.6 ± 1.7 vs. 8.2 ± 1.3%; p = 0.01) and lower values for BMI (24.3 ± 4.1 vs. 27.2 ± 2.6 kg/m 2 ; p = 0.02), body fat percentage (26.6 ± 6.2 vs. 30.8 ± 7.7%; p = 0.04), and waist circumference (78.7 ± 8 vs. 85.8 ± 8.1 cm; p = 0.02). No association was found between the symptoms and the presence of Helicobacter pylori. Conclusions: Dyspepsia symptoms in patients with long-standing DM1 were associated with glycemic control and depression, and they seem to negatively influence the nutritional status of these patients. Arch Endocrinol Metab. 2015;59(2):129-36

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Section: Discussionsupporting

confidence: 79%

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Faria

Pavin

Parisi

et al. 2015

Arch. Endocrinol. Metab.

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“…However, the association between H. pylori infection and diabetes is controversial in the literature. A higher prevalence of H. pylori infection in diabetic than in control subjects has been reported in some studies (37,38), whereas other studies have found no association between H. pylori and diabetes (39,40). In this study, we found no significant correlation between FPG levels and H. pylori status.…”

Section: Mckeown-eyssencontrasting

confidence: 53%

Impact of Fasting Plasma Glucose Levels on Gastric Cancer Incidence in a General Japanese Population

et al. 2005

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MITSUO IIDA, MD 1 OBJECTIVE -Several studies have shown associations between diabetes and various types of cancer other than gastric cancer. The aim of this cohort study was to evaluate the impact of fasting plasma glucose (FPG) levels on gastric cancer occurrence. RESEARCH DESIGN AND METHODS -A total of 2,466Japanese subjects aged Ն40 years were stratified into three groups according to FPG tertiles (Ͻ5.3 mmol/l, low FPG; 5.3-5.8 mmol/l, modest FPG; Ͼ5.8 mmol/l, high FPG) and followed up prospectively for 9 years.RESULTS -During the follow-up, 66 subjects experienced gastric cancer. In men, the ageadjusted incidences were significantly higher in the modest-FPG (7.0 per 1,000 person-years, P Ͻ 0.05) and high-FPG (7.2, P Ͻ 0.05) groups than in the low-FPG group (2.2). In women, the high-FPG group also had a significantly higher age-adjusted incidence of gastric cancer compared with the low-FPG group (2.5 vs. 0.8, P Ͻ 0.05). The multivariate analysis with Cox's proportional hazards model revealed that the risks of gastric cancer in the modest-FPG (relative risk [RR] 2.3 [95% CI 1.1-5.0]) and high-FPG (3.1 [1.5-6.4]) groups were significantly higher than that in the low-FPG group, even after adjusting for other comprehensive risk factors, including Helicobacter pylori status, smoking, and dietary factors. However, this FPG-cancer association was observed only among H. pylori-seropositive subjects.CONCLUSIONS -Our findings suggest that a modest increase in FPG is a risk factor for gastric cancer and that hyperglycemia is a possible cofactor increasing the risk posed by Helicobacter pylori infection. Diabetes Care 28:789 -794, 2005T he Japanese population is characterized by a high morbidity from gastric cancer and a high prevalence of Helicobacter pylori infection, especially in middle-aged and elderly individuals (1).We have previously reported a significant relationship between infection with H. pylori and a subsequent occurrence of gastric cancer for men in a general Japanese population (2). However, only a small percentage of people with H. pylori infection develop gastric cancer, indicating that H. pylori cannot be the only etiologic factor of gastric cancer; other cofactors must affect the relationship between H. pylori infection and the development of gastric cancer.On the other hand, a possible association between diabetes and an increase in mortality from malignant neoplasm has been discussed for many years (3). Several prospective cohort studies have examined the associations between diabetes and total cancers (4 -7). Among them, three studies have demonstrated that diabetes is associated with an excess risk for all cancers (4 -6), while another study could not confirm a positive association between diabetes and total cancer (7). Several recent studies have shown associations between diabetes and cancer in the pancreas (8,9), liver (8,10), and large bowel (11,12). To our knowledge, none of the previous studies evaluated the impact of hyperglycemia on the development of gastric cancer.In the present invest...

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“…Zelenkova had reported a prevalence of H. pylori to be lower in diabetics compared to non-diabetic controls (27% vs. 51%) [27,28]. In other studies, the prevalence of H. pylori infection was comparable between diabetic and control [10][11][12][13][14][15][16][17]. In our study we found no significant association between H. pylori and diabetes (p=0.979).…”

Section: Discussioncontrasting

confidence: 52%

“…Another explanation may be that the immune status in diabetic patients, which is strongly compromised, may lead to an increased susceptibility to H. pylori infection [3]. However, the link between H. pylori infection and diabetes remains controversial, as some studies indicate a higher prevalence of infection in diabetic patients, [4][5][6][7][8], while others report no difference [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection among Symptomatic Patients, Correlation with Endoscopic Findings and it’s Association with Type II Diabetes Mellitus

Abboud¹,

Khalek²

2017

J Gastrointest Dig Syst

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Helicobacter Pylori Infection Is Not Associated With Diabetes Mellitus, Nor With Upper Gastrointestinal Symptoms in Diabetes Mellitus

Abstract: H. pylori infection appears not to be associated with diabetes mellitus or upper GI symptoms in diabetes mellitus.

Cited by 94 publications

References 32 publications

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Dyspeptic symptoms in patients with type 1 diabetes: endoscopic findings, Helicobacter pylori infection, and associations with metabolic control, mood disorders and nutritional factors

Impact of Fasting Plasma Glucose Levels on Gastric Cancer Incidence in a General Japanese Population

Epidemiology of Helicobacter pylori Infection among Symptomatic Patients, Correlation with Endoscopic Findings and it’s Association with Type II Diabetes Mellitus

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