Helicobacter Pylori Infection is Associated with Portal ‎Hypertensive Gastropathy in Patients with Liver Cirrhosis ‎

El-Toukhy, Naglaa; El-Farouk, Lubna Omar; Youssef, Marwa

doi:10.21608/aeji.2020.47568.1112

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…The MELD score was 17.68 ± 3.43 in patients with PHG and 16.58 ± 2.09 in patients without PHG ( p = 0.015). This is consistent with two studies by El-Toukhy et al ( 23 ) and El-Masry et al ( 24 ), which found that the prevalence of H. pylori in HCV-infected patients rose considerably as the MELD score increased. This is in contrast to Safwat et al ( 20 ), Abbas et al ( 21 ), and Eid et al ( 12 ), who found that there was no significant link between PHG and MELD scores ( p = 0.468, 0.921, and 0.396, respectively).…”

Section: Discussionsupporting

confidence: 93%

“…In our current research, the frequency of H. pylori infection was 55% in patients with PHG, while it was only 27.5% in patients without PHG ( p < 0.001). This is in line with Safwat et al ( 20 ), El-Toukhy et al ( 23 ), and Sathar et al ( 27 ).…”

Section: Discussionsupporting

confidence: 91%

“…This is in line with the findings of Safwat et al ( 20 ), Abbas et al ( 21 ),and Eid et al ( 12 ) ( p = 0.59, 0.735, and 0.423, respectively). On the contrary, Kim et al ( 22 ) and El-Toukhy et al ( 23 ) found a significant link between PHG and Child score. The vulnerability of the gastric mucosa to harm caused by irritants such as ethyl alcohol, bile salts, aspirin, or classic non-steroid anti-inflammatory medications, and spontaneous bleeding may be influenced by liver dysfunction.…”

Section: Discussionmentioning

confidence: 90%

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Helicobacter pylori Infection in Cirrhotic Patients With Portal Hypertensive Gastropathy: A New Enigma?

et al. 2022

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The relationship between Helicobacter pylori (H. pylori) infection and Portal hypertensive gastropathy (PHG) is still a debatable matter. The aim of this study is to find out how common H. pylori infection is in cirrhotic patients with PHG and to see if there’s a link between H. pylori infection and PHG severity. Out of 340 cirrhotic patients who had upper Gastrointestinal Tract (GIT) endoscopy for early varices screening, 160 cirrhotic patients were selected and divided into 2 groups; 80 cirrhotic patients with PHG (cases) and 80 cirrhotic patients without PHG (controls). Gastric biopsies were taken from all enrolled patients for histological evaluation for the presence or absence of H. pylori infection. H. pylori was found in 44 cirrhotic patients (55%) who had PHG (cases), compared to 22 cirrhotic patients (27.5%) who did not have PHG (controls). The prevalence of H. pylori infection was significantly higher in patients with PHG (p < 0.001). The severity of PHG was associated with H. pylori infection (p < 0.001). The response to eradication therapy of H. pylori infection was must better in patients without PHG (p = 0.045). By multi-variant analysis, H. pylori infection, splenic diameter, and portal vein diameter were independent predictors for PHG presence. After treating H. pylori infection in patients who tested positive for H. pylori, there was a significant reduction in PHG severity (p < 0.001). Patients with PHG have a greater prevalence of H. pylori infection. PHG is more severe in patients infected with H. pylori. To improve PHG severity, cirrhotic patients must have their H. pylori infection eradicated.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 90%

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Helicobacter pylori Infection in Cirrhotic Patients With Portal Hypertensive Gastropathy: A New Enigma?

et al. 2022

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“…Numerous studies have shown an increased prevalence of H. pylori in portal hypertensive gastropathy; however, the true mechanism for this higher prevalence remains obscure, with different studies postulating different mechanisms. One of the popular theories is that H. pylori causes hypoxic mucosal surface and diminished epithelial integrity, which may facilitate colonization with this organism, while others claim that mucosal swelling and congestion, which increase nitric oxide, act as a suitable media for the growth of H. pylori [ 5 - 7 , 10 ]. Still, another famous theory is that in PHG, there is mucosal thinning and higher pH with decreased prostaglandin levels, facilitating H. pylori .…”

Section: Discussionmentioning

confidence: 99%

“…One of the dreaded complications of H. pylori infection is gastric cancer, especially adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphomas. However, there is a controversy regarding its relationship with PHG in patients with liver cirrhosis [4][5][6][7]. Understanding the frequency of H. pylori infection in patients with liver cirrhosis and its association with PHG can be helpful in comprehending its probable involvement [3].…”

Section: Introductionmentioning

confidence: 99%

The Association of Helicobacter pylori With Portal Hypertensive Gastropathy in Patients With and Without Cirrhosis

.¹,

Mansoor²,

Din³

et al. 2022

Cureus

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Introduction: Cirrhosis and its associated complication of portal hypertensive gastropathy (PHG), among others, remain a significant cause of death in resource-poor countries with limited capacity for liver transplantation. This research aimed to assess the association of Helicobacter pylori (H. pylori) with portal hypertensive gastropathy and its severity in patients with and without cirrhosis.Methodology: The study was conducted at a tertiary care hospital in Pakistan from April 2021 to May 2022. Liver cirrhosis was diagnosed by clinical manifestations, ultrasonography, and laboratory investigations. The severity of liver cirrhosis was assessed using the Child-Pugh scoring system. The association of H. pylori with portal hypertensive gastropathy in patients with and without cirrhosis was assessed using the chisquare test.Results: A total of 120 patients participated in the study, of which 40 were without liver cirrhosis, while 80 were with cirrhosis. Among patients with cirrhosis, 24 were in Child-Pugh class A, 26 in class B, and 30 in class C. Of patients with liver cirrhosis who were H. pylori-negative, 37.5% (15/40) had portal hypertensive gastropathy. Of these, 12.5% (5/40) had severe PHG, while 25% (10/40) had mild PHG. Of patients with liver cirrhosis who were H. pylori-positive, 62.5% (25/40) had PHG. Of these, 2.5% (1/40) had severe PHG, while 60% (24/40) had mild PHG. Helicobacter pylori contributed nonsignificantly (p=0.080), showing no association with portal hypertensive gastropathy. Conclusion:Helicobacter pylori does not appear to have any significant association to cause or worsen portal hypertensive gastropathy in patients with liver cirrhosis.

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endoscopic study on portal hypertensive colopathy in cirrhotic patients

Hussain¹,

Fazal²,

Farooq³

et al. 2023

ijhs

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Background and Aim: Liver Cirrhosis patients are more prone to lower gastrointestinal (GI) bleeding hypothetically caused by portal hypertensive colopathy (PHC) and anorectal varices (ARVs). The present study aimed to determine the incidence of colopathic lesions and investigate their association with cirrhosis severity and portal hypertensive colopathy manifestation. Patients and Methods: This cross-sectional study was carried out on 80 liver cirrhosis patients in the Department of Gastrointestinal, CMH Hospital Lahore from January 2021 to December 2022. Individuals aged >18 years with liver cirrhosis were enrolled. Each individual underwent laboratory, clinical, and ultrasonographic examinations. Upper gastrointestinal endoscopy was used to detect the PHC. Based on the colopathic lesions severity, patients were categorized into three grades: grade I (colonic mucosa), grade II (mucosa with mosaic-like pattern), and grade III (angiodysplasia-like colon lesions). SPSS version 27 was used for data analysis. Results: The overall mean age was 48.62±5.6 years with an age range 19 to 70 years. Of the total patients, there were 60 (75%) male and 20 (25%) females. Child-Pugh classification of patients were as follows: Class A 16 (20%), Class B 29 (36.3%), and Class C 35 (43.7%).

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Helicobacter Pylori Infection is Associated with Portal ‎Hypertensive Gastropathy in Patients with Liver Cirrhosis ‎

Cited by 3 publications

References 17 publications

Helicobacter pylori Infection in Cirrhotic Patients With Portal Hypertensive Gastropathy: A New Enigma?

Helicobacter pylori Infection in Cirrhotic Patients With Portal Hypertensive Gastropathy: A New Enigma?

The Association of Helicobacter pylori With Portal Hypertensive Gastropathy in Patients With and Without Cirrhosis

endoscopic study on portal hypertensive colopathy in cirrhotic patients

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