Helicobacter Pylori Infection is a Significant Risk for Modified Lipid Profile in Japanese Male Subjects

Satoh, Hiroki; Saijo, Yasuaki; Yoshioka, Eiji; Tsutsui, Hiroyuki

doi:10.5551/jat.5157

Cited by 88 publications

(71 citation statements)

References 34 publications

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“…The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects 7) . Additionally, the present study enrolled general healthy Japanese populations.…”

Section: On Lipid Profile and Helicobacter Pylori Infectionsupporting

confidence: 48%

On Lipid Profile and Helicobacter Pylori Infection

Satoh

2011

JAT

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Section: On Lipid Profile and Helicobacter Pylori Infectionsupporting

confidence: 48%

On Lipid Profile and Helicobacter Pylori Infection

Satoh

2011

JAT

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“…Although previous studies of the association between H. pylori and the serum lipid levels have often yielded contradictory results, those findings have generally indicated that patients with this infection have a moderately increased risk of dyslipidemia 122,124,125) . Moreover, H. pylori infection has been shown to be associated with decreased HDL cholesterol (HDL-c), apoAI and HDL-c to total cholesterol values and increased apoB levels, indicating that current infection with H. pylori is correlated with an atherogenic modified lipid profile 122,123,126) . These changes are thought to be mediated by cytokines, particularly TNF-α, which inhibits lipoprotein lipase and thus results in the mobilization of lipids from tissues as well as elevation of serum triglycerides and reductions in HDL-c 127) .…”

Section: H Pylori Related-inflammation and Atherosclerosismentioning

confidence: 99%

“…CRP may elicit a wide array of pro-atherogenic effects, including the stimulation of leukocyte-endothelium interactions, induction of a prothrombotic state and activation of the complement system 91) . IL-6 is an upstream inflammatory cytokine that plays a central role in propagating the downstream infection, such as that involving H. pylori, represent an atherogenic link [122][123][124] . Although previous studies of the association between H. pylori and the serum lipid levels have often yielded contradictory results, those findings have generally indicated that patients with this infection have a moderately increased risk of dyslipidemia 122,124,125) .…”

Section: H Pylori Related-inflammation and Atherosclerosismentioning

confidence: 99%

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Yang

Lü

2014

JAT

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Accumulating evidence implicates Helicobacter pylori (H. pylori) infection in the pathogenesis of certain diseases localized outside the stomach, particularly those characterized by persistent and lowgrade systematic inflammation. Recently, the role of H. pylori infection in the development of atherosclerosis and its clinical complications has received attention. Atherosclerosis is a high-cost disease, and acute events resulting from this condition rank first among morbidity and mortality statistics in most industrialized countries. Atherosclerosis is a multifactorial disorder, and traditional risk factors explain only 50% of its etiology. Therefore, identifying new risk factors for atherosclerosis is necessary. Serological studies indicate that chronic H. pylori infection, especially that with more virulent strains, may predispose patients to the onset of atherosclerosis and related adverse clinical events, and PCR studies have detected H. pylori DNA in atherosclerotic plaques, although this finding remains controversial. If this association were to be confirmed, its importance to public health would be substantial, as the eradication of H. pylori is more straightforward and less costly than the longterm treatment of other risk factors. This review investigates the potential relationship between H. pylori infection and atherosclerosis from both epidemiological and pathogenic perspectives and characterizes the potential mechanisms underlying this correlation.

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“…20 Also, significant correlations between low HDL-C levels with Helicobacter pylori infection were found in Japanese males. 21 Also, studies have identified a link between HDL size and adiposity markers such as WC or visceral fat assessed by computed tomography. 22 Our results extend these previous findings in wellphenotyped, overweight, lipid-lowering treatment-free patients with abdominal obesity.…”

Section: Discussionmentioning

confidence: 99%

Waist circumference is a strong and independent determinant of the distribution of HDL subfractions in overweight patients with cardiovascular risk factors

Rosenbaum

Hansel

Bonnefont‐Rousselot

et al. 2012

Diabetes and Vascular Disease Research

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Purpose: Our aim was to determine the influence of waist circumference on the repartition of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions in patients with increased waist perimeter and one or more cardiovascular risk factor. Methods: All 117 patients without lipid-lowering therapy underwent routine clinical, biological evaluation and isolation of the following lipid subfractions: HDL2b, HDL2a, HDL3a, HDL3b, HDL3c and LDL1, LDL2, LDL3, LDL4. Results: Mean waist circumference was 102.9 cm for women and 109.4 cm for men, and 92 patients presented with metabolic syndrome. In the highest waist circumference tertile, when compared with the lowest one, an increased HDL3c (7.7% vs. 5.7% p=0.02) and a non-significant decrease of HDL2b percentages were observed with no difference in other subfractions. In multivariate analysis, only plasma triglycerides and waist circumference remained independent predictors of HDL3c percentage. Conclusion: In our population, waist circumference was a strong and independent determinant of a shift in the distribution of HDL toward denser particles.

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Helicobacter Pylori Infection is a Significant Risk for Modified Lipid Profile in Japanese Male Subjects

Abstract: Conclusions:The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.

Cited by 88 publications

References 34 publications

On Lipid Profile and Helicobacter Pylori Infection

On Lipid Profile and Helicobacter Pylori Infection

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Waist circumference is a strong and independent determinant of the distribution of HDL subfractions in overweight patients with cardiovascular risk factors

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