Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population

Li, Wei; Minohara, Motozumi; Su, Jen Jen; Matsuoka, Takeshi; Osoegawa, Manabu; Ishizu, Takaaki; Kira, Jun Ichi

doi:10.1016/j.jneuroim.2006.12.010

Cited by 97 publications

(87 citation statements)

References 16 publications

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“…A recent case control study in Iran also reported that neurological disability was lower in H. pylori-seropositive than in seronegative MS patients (Mohebi et al, 2013), in agreement with a previous study in a Japanese MS patient cohort (Li et al, 2007). In contrast, some other studies have failed to find any association between H. pylori infection and MS (Danese et al, 2000), and there is strong serological evidence to support a positive association between H. pylori and neuromyelitis optica (NMO), an antibody-mediated, severe variant of MS that involves the spinal cord and the optic nerves (reviewed by Smyk et al, 2014).…”

Section: Introductionsupporting

confidence: 88%

“…There have been a number of cross-sectional epidemiological studies reporting a lower prevalence of H. pylori amongst patients with multiple sclerosis (MS) (Wender, 2003;Li et al, 2007;Mohebi et al, 2013;Yoshimura et al, 2014). A recent case control study in Iran also reported that neurological disability was lower in H. pylori-seropositive than in seronegative MS patients (Mohebi et al, 2013), in agreement with a previous study in a Japanese MS patient cohort (Li et al, 2007).…”

Section: Introductionsupporting

confidence: 75%

“…We and others demonstrated a negative association between H. pylori infection and Western-type (Kira et al, 1996) MS in patients (Wender, 2003;Li et al, 2007;Mohebi et al, 2013;Yoshimura et al, 2014), however, this approach could not establish a causal relationship. H. pylori may merely be a marker for other protective factors.…”

Section: Discussionmentioning

confidence: 67%

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Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis

Gran

Crooks

Cook³

et al. 2015

Journal of the Neurological Sciences

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Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compare the prevalence of H. pylori amongst MS patients and healthy controls, and also investigated the impact of this infection on an animal model for MS, experimental autoimmune encephalomyelitis (EAE). The H. pylori status of 71 MS patients and 42 healthy controls was determined by serology. Groups of C57BL/6 mice were infected with H. pylori, or given diluent alone as a placebo, prior to inducing EAE. Clinical scores were assessed for all mice, and spleens and spinal cord tissue were harvested. CD4 + T cell subsets were quantified by flow cytometry, and T cell proliferation assays were performed. In MS patients the seroprevalence of H. pylori was half that of healthy controls (p = 0.018). Over three independent experiments, prior H. pylori infection had a moderate effect in reducing the severity of EAE (p = 0.012). In line with this, the antigen-specific T cell proliferative responses of infected animals were significantly reduced (p = 0.001), and there was a fourfold reduction in the number of CD4 + cells in the CNS. CD4 + populations in both the CNS and the spleens of infected mice also contained greatly reduced proportions of IFNγ + , IL-17 + ,T-bet + , and RORγt + cells, but the proportions of Foxp3 + cells were equivalent.There were no differences in the frequency of splenic CD4 + cells expressing markers of apoptosis between infected and uninfected animals. H. pylori was less prevalent amongst MS patients. In mice, the infection exerted some protection against EAE, inhibiting both Th1 and Th17 responses. This could not be explained by the presence of increased numbers of Foxp3 + regulatory T cells, or T cell apoptosis. This is the first direct experimental evidence showing that H. pylori may provide protection against inflammatory demyelination in the CNS.

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Section: Introductionsupporting

confidence: 88%

Section: Introductionsupporting

confidence: 75%

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Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis

Gran

Crooks

Cook³

et al. 2015

Journal of the Neurological Sciences

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“…H. pylori was investigated whether it is related with several autoimmune diseases or not and it was found to be associated with development and severity of Sjögren's syndrome, Systemic sclerosis and Psoriasis while no relation was found with RA, Systemic lupus erythematosus, vasculitides, chronic urticaria, Immune thrombocytopenic purpura and Hashimoto's thyroiditis [17]. On the other hand, several studies indicated H. pylori as a potential protective agent against Multiple Sclerosis [18,19]. However, the impacts of H. pylori infection on disease severity and clinical findings of AS has not been fully clarified yet.…”

Section: Discussionmentioning

confidence: 99%

The Impacts of Helicobacter Pylori Antigen Positivity on Ankylosing Spondylitis

İnal¹

2016

Ann Clin Anal Med

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“…H. pylori infection has a potential role in MS development in certain population. H. pylori infection is supposed to occur mainly before 2 years of age, primarily because the parietal cells that secrete gastric acids, which hamper the survival of H. pylori, are not mature enough during infancy [6].…”

Section: Introductionmentioning

confidence: 99%

Association and linkage of definite multiple sclerosis with HLA and the potential protective role of Helicobacter pylori infection among Egyptians

Elmongui

Khalil²,

Salama³

et al. 2016

Int Arch Med

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Background: Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system. The linkage of multiple sclerosis to the Human Leukocyte Antigen (HLA) has been known a few decades ago. Some investigators have shown a relationship between H. pylori infection and Multiple sclerosis development. However, this relationship is still controversial.Objectives: This study was designed to detect the linkage between HLA-DRB1 types and Multiple Sclerosis development, clinical presentation and course, and to try solving the controversy of the role of H. pylori infection in Multiple Sclerosis. Methods:This study was carried out on 130 Egyptian individuals at the Neurology department of Mansoura University Hospital in 2012-2015. Group I included 80 definite relapsing remittent MS patients and Group II included 50 healthy control people. Both patients and control groups were subjected to HLA-DRB1 typing using the INNOLiPA HLA-DRB1 Plus kit. Correlation of HLA-DRB1 type to clinical presentation and course of the disease was tested. Both study groups were subjected to H. pylori CagA and VacA IgG detection in their sera by qualitative immunoassay. All statistical analyses were performed using SPSS version 16.0.Results: Data pooled from this study showed that number of MS cases with HLA-DRB1 * 1, 4 &7 is statistically significantly higher than it was in the control group (P=0.01, P=0.049 and P=0.02 respectively). The number of control individuals with HLA-DRB1 * 15g &11 types was statistically significantly higher than it was in MS patients (P=0.003 and P<0.001). Data also showed that the frequency of H. pylori antibody positive individuals is more than the negative ones in the MS patients' group but the difference was statistically insignificant (P>0.05).

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Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population

Cited by 97 publications

References 16 publications

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis

The Impacts of Helicobacter Pylori Antigen Positivity on Ankylosing Spondylitis

Association and linkage of definite multiple sclerosis with HLA and the potential protective role of Helicobacter pylori infection among Egyptians

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