Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women

Fujimori, Shunji; Kishida, Teruyuki; Kobayashi, Tsuyoshi; Sekita, Yoshihisa; Seo, Tsuguhiko; Nagata, Kazuhiro; Tatsuguchi, Atsushi; Gudis, Katya; Yokoi, Kimiyoshi; Tanaka, Noritake; Yamashita, Kiyohiko; Tajiri, Takashi; Ohaki, Yoshiharu; Sakamoto, Choitsu

doi:10.1007/s00535-005-1649-1

Cited by 73 publications

(72 citation statements)

References 36 publications

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“…A limited number of previous hospital-based case-control (22,23) and comparative studies (24)(25)(26)(27)(28) have reported an increased risk of colorectal neoplasia in the presence of H. pylori infection. As for CAG, two reports have described non-significant results for the correlation between colorectal cancer and CAG (29,30).…”

Section: Discussionmentioning

confidence: 99%

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

Inoue

Kato

Yoshimura

et al. 2012

Molecular and Clinical Oncology

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Abstract.In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects of H. pylori-associated chronic gastritis on the development of colorectal neoplasia by analyzing the recurrence of colorectal neoplasia subsequent to endoscopic resection. Ninety-nine patients who had undergone endoscopic resection of colorectal neoplasia were monitored under colonoscopy, and the recurrence of colorectal neoplasia was prospectively investigated. The stage of H. pylori-associated chronic gastritis in each subject was evaluated using a combination of two serum tests: H. pylori antibody and pepsinogen. In the present cohort, colorectal neoplasia recurred at a rate of 15,296/100,000 person-years during the study period. After adjusting for the confounding factors, chronic atrophic gastritis (CAG) was identified as an independent risk factor [adjusted hazard ratio (HR), 2.72; 95% confidence interval, 1.33-5.57], while H. pylori-infected non-atrophic gastritis was not identified as an independent risk factor for recurrent colorectal neoplasia. Colorectal neoplasia recurred earlier and was significantly more frequent in patients with CAG (22,573/100,000 person-years) compared to patients without CAG (11,089/100,000 person-years; P=0.029, log-rank test).Patients with more extensive CAG showed a higher risk of recurrence. These results demonstrated a significant elevation of the risk of recurrent colorectal neoplasia with the establishment and progression of CAG, indicating the involvement of H. pylori infection in the development of colorectal neoplasia. The two serum tests were useful clinical markers for noninvasively evaluating the risk of each individual for recurrent colorectal neoplasia subsequent to endoscopic resection.

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Section: Discussionmentioning

confidence: 99%

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

Inoue

Kato

Yoshimura

et al. 2012

Molecular and Clinical Oncology

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“…On the other hand, the greatest risk for colonic adenomas in women is associated with hormonal factors (6) . The mean age of the female patients examined in this study was over 50 years, so they probably had reduced levels of sex hormones.…”

Section: Resultsmentioning

confidence: 99%

“…Estrogen and progesterone reduce the risk of adenomas and of adenocarcinomas in the colon. A possible interaction between H. pylori and low levels of female sex hormones was described in the development of colonic neoplasias in women (6) . When the cases in our study were evaluated in accordance with the histological type of the adenomas, the data showed that H. pylori infection was significantly prevalent only in individuals with tubular adenomas.…”

Section: Resultsmentioning

confidence: 99%

“…These findings are in accordance with those of some other studies in which a similar methodology was used. Some of these studies found a greater prevalence of the bacteria in patients with colon adenomas or adenocarcinomas than in those of the control group (1,2,5,6,10,11,23,24,30) . However, different results from those of our study and of the above studies were also reported.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Buso

Rocha

Diogo

et al. 2009

Arq. Gastroenterol.

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-Context -The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results. Objective -To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal. Methods -After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data. Results -There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 ± 12.25 years and that of the controls was 58.98 ± 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038). Conclusion -There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location. HEADINGS -Helicobacter pylori. Adenoma. Colonic neoplasms. Helicobacter infections.

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“…These data show that the frequent coexistence of colonic polyps and gastric IM may not be explained only by H. pylori infection and hypergastrinemic atrophic gastritis. A study by Fujimori et al (27) in Japan reported a steadily decreasing prevalence of H. pylori infection, while the prevalence of CRC increased. Other factors besides H. pylori infection might increase the rate of CRC; however, further investigations are required.…”

Section: Discussionmentioning

confidence: 99%

Is there any association between colonic polyps and gastric intestinal metaplasia?

Unler¹,

Ozgur²,

Gokturk³

et al. 2016

Turk J Gastroenterol

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Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women

Abstract: The results therefore suggest that, in patients aged 40-80 years, H. pylori infection increased the risk of colorectal adenoma and adenocarcinoma, with significantly higher risks for female patients.

Cited by 73 publications

References 36 publications

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Is there any association between colonic polyps and gastric intestinal metaplasia?

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