Helicobacter pylori Infection in Preschool and School-Aged Minority Children: Effect of Socioeconomic Indicators and Breast-Feeding Practices

Malaty, Hoda M.; Logan, Nancy; Graham, David Y.; Ramchatesingh, Jacqueline

doi:10.1086/320148

Cited by 90 publications

(92 citation statements)

References 31 publications

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“…A very strong body of evidence exists showing that promiscuity, particularly family overcrowding (large number of offspring and bed sharing), is associated with H. pylori infection in children. 2,4,7,[15][16][17] Currently, to our knowledge, the association of lower risk of H. pylori seroprevalence in children of young mothers found in our study had never been reported. However, it may only reflect a smaller number of offspring in young families.…”

Section: Discussioncontrasting

confidence: 57%

Prevalence of and Factors Associated With Helicobacter Pylori Infection in Children in the North of Vietnam

Nguyen¹,

Nguyen²,

Phung³

et al. 2006

Am J Trop Med Hyg

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Abstract. The study aimed at evaluating the seroprevalence of and sociodemographic, health, lifestyle, and environmental hygiene conditions associated with Helicobacter pylori infection in Vietnamese children. Data from 824 children, aged from 6 months to 15 years and gastrointestinal symptom free when consulted, admitted to a university hospital, were collected using a structured questionnaire and ELISA test for H. pylori infection. The data were examined using univariate and multivariate analyses. H. pylori seroprevalence was 34.0%. Age groups from 3 to 6 years and older than 6, and number of offspring were positively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 2.9 (1.5-5.5); 1.9 (1.1-3.1) and 1.8 (1.1-2.6), respectively]. Breastfeeding more than 6 months was negatively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 0.5 (0.3-0.9)]. Mother's age, history of allergy, gastro-duodenal disease history in the past, initiating collective life before 6 years, sharing bed with parents and time of bed sharing with parents > 24 months were positively but not independently associated with H. pylori seropositivity. None of the other environmental or lifestyle conditions examined was associated with H. pylori infection. Our results support person-to-person transmission and the role of sociodemographic factors in H. pylori infection.

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Section: Discussioncontrasting

confidence: 57%

Prevalence of and Factors Associated With Helicobacter Pylori Infection in Children in the North of Vietnam

Nguyen¹,

Nguyen²,

Phung³

et al. 2006

Am J Trop Med Hyg

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“…In a case-control study by Children's medical center, it was shown that breastfeeding during the first 6 months of life resulted in lower H. pylori colonization, decrease in duration of symptoms, and less severe gastritis (17). In a Turkish-American study, breastfeeding was dis-cussed as an important protective factor for H. pylori infection (18,19). In a systematic review by Klein et al it was suggested that breast milk protects against H. pylori infection (20).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

et al. 2017

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Background: Helicobacter pylori is a common gastrointestinal pathogen in human. The mechanism of its acquisition and transmission is unclear, although the most likely mode of transmission is fecal-oral or oral-oral. Most of infections occur in childhood. The current cohort assessed the prevalence of infection in infants with different feeding strategies (exclusive breastfeeding, formula, or mixed feeding). Methods: The current study was carried out in Vali-Asr hospital of Imam Khomeini hospital complex, Tehran, Iran, from 2012 to 2015.The study population included infants born in this hospital and registered in breastfeeding research center during the first 6 months of life. They were compared in 2 groups; exclusively breastfed, and formula or mixed fed. Mothers' H. pylori infection was checked serologically using the enzyme-linked immunosorbent assay (ELISA) technique and those of infants by monoclonal antibody test using ELISA technique on stool samples at 1st and 6th month of life. Results: A total of 102 infants in 2 groups (54 exclusively breastfed and 48 formula or mixed fed) completed the study. Mothers' serological assessments were positive in 68% of exclusively breast-fed subjects and 60% of formula or mixed fed subjects. All 1-monthold infants were negative for the infection and in the 6-month-old infants 10 cases (18.5%) were positive, 1 case was at borderline in the exclusively breastfed, and 13 cases (27%) were positive in formula-or mixed-fed subjects. This difference was not statistically significant (P = 0.302). The Mantel-Hanzel test was used to find a relationship in H. pylori positivity in mothers and infants during the first 6-month of life in each of the 2 groups. It was found that out of 37 serologically positive mothers in the breastfed group, 8 infants (22%) were H. pylori positive and in the formula and mixed-fed group, of 29 serologically positive mothers 10 infants (34%) were also H. pylori positive, but the difference between the groups was not statistically significant (P = 0.727). It meant that the prevalence of infantile H. pylori infection was similar in the 2 groups. Conclusions: The current study findings showed that exclusive breastfeeding had no role in protection or facilitation of H. pylori infection.

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“…The results of the present study showed that the overall seroprevalence of H pylori infection was 46.6% in children at age 1-15 years and was 67.5% in adults at age 20-60 years. In different studies, the prevalence of H pylori is variable in children such that it has been reported to be 60% at age 4 years in Ethiopia [11] , 7.5% at age 2-18 years in Czech [12] , 44% at age 6 mo to 17 years in Turkey [13] , 8% at age 1-3 years in USA [14] , 50% at age 1-9 years and 80% at age 10-19 years in Libya [15] , 56% at age 1-14 years in Brazil [16] , 96% at age 1-14 years in Saudi Arbia [17] and 80% at age 1.5-5 years in Bangladesh [18] . Moreover, It has been reported that children in Gambia and Nigeria are almost all infected by H pylori at age of 5 years [19,20] .…”

Section: Discussionmentioning

confidence: 99%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS:The seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001). CONCLUSION:These results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori -specific antibodies influenced by age and sex of subjects. Moreover, it seems that males are more susceptible to infection with CagA + strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.

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Helicobacter pylori Infection in Preschool and School-Aged Minority Children: Effect of Socioeconomic Indicators and Breast-Feeding Practices

Cited by 90 publications

References 31 publications

Prevalence of and Factors Associated With Helicobacter Pylori Infection in Children in the North of Vietnam

Prevalence of and Factors Associated With Helicobacter Pylori Infection in Children in the North of Vietnam

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

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