Helicobacter pylori infection in pernicious anemia: A prospective controlled study

Fong, Tse‐Ling; Dooley, Cornelius P.; Dehesa, Margarita; Cohen, Hartley; Carmel, Ralph; Fitzgibbons, Patrick L.; Pérez-Pérez, Guillermo I.; Blaser, Martin J.

doi:10.1016/0016-5085(91)90199-u

Cited by 138 publications

(62 citation statements)

References 16 publications

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“…Models for the pathogenesis of HP-associated autoimmunity are molecular mimicry and/or T-helper 1-induced expression of HLA class II and costimulatory molecules on gastric epithelial cells (24 -26). However, we and others (35,46,47) have found no or a negative relation between HP infection and autoimmune gastritis. Nevertheless, eradicating HP and doing a rebiopsy 6 months later to note its effect on histology is recommended.…”

Section: Hp Infectioncontrasting

confidence: 70%

“…Longitudinal studies suggest that HP may induce early stages of autoimmune gastritis by stimulating granulocytes to produce autodestructive oxygen radicals, which are mutagenic and ultimately lead to corpus atrophy (45) and HP self-destruction due to intestinal metaplasia or achlorhydria (46). Models for the pathogenesis of HP-associated autoimmunity are molecular mimicry and/or T-helper 1-induced expression of HLA class II and costimulatory molecules on gastric epithelial cells (24 -26).…”

Section: Hp Infectionmentioning

confidence: 99%

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Autoimmune Gastropathy in Type 1 Diabetic Patients With Parietal Cell Antibodies

et al. 2003

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OBJECTIVE -Approximately 15-20% of type 1 diabetic patients exhibit parietal cell antibodies (PCAs) targeting gastric H ϩ /K ϩ ATPase. We examined whether iron deficiency anemia, pernicious anemia, and autoimmune gastritis, which may predispose to gastric tumors, were more frequent in PCA ϩ than in PCA -patients. RESULTS -Autoimmune gastritis (AG) was present in 57% of PCA ϩ and 10% of PCA -cases (OR 12.5, P Ͻ 0.0001). PCA positivity (␤ ϭ 1.44; P ϭ 0.04) and hypergastrinemia (␤ ϭ 0.01; P ϭ 0.026), but not HP, age, diabetes duration, sex, and HLA-DQ type were risk factors for AG. Iron deficiency anemia (OR 3.9, P ϭ 0.015), pernicious anemia (OR ϭ 4.6, P ϭ 0.022), and hypochlorhydria (OR ϭ 20.0, P ϭ 0.0002) were more frequent in AG ϩ individuals. HP infection was present in 47 patients but did not influence corpus histology or gastrinemia. (Pre)malignant lesions were found in 26% of PCA ϩ subjects: ECL cell hyperplasia in 7 AG ϩ patients, comprising 1 with a gastric carcinoid tumor, and corpus intestinal metaplasia in 11 AG ϩ patients, including 1 with linitis plastica. RESEARCH DESIGN AND METHODS CONCLUSIONS -PCAϩ type 1 diabetic patients should be screened for autoimmune gastritis, iron deficiency, and pernicious anemia. Particularly hypergastrinemic PCA ϩ patients with autoimmune gastritis are at increased risk for (pre)malignant gastric lesions.

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Section: Hp Infectioncontrasting

confidence: 70%

Section: Hp Infectionmentioning

confidence: 99%

Autoimmune Gastropathy in Type 1 Diabetic Patients With Parietal Cell Antibodies

et al. 2003

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“…(iv) A double intoxication then occurs, justifying numerous extradigestive pathologies described in Table 2. (v) This statement is in perfect harmony with recent literature which reports more and more extra-digestive pathologies linked to Helicobacter pylori [23,28,[35][36][37][38][39][40][41].…”

Section: Drc Helicobacter Pylori Phenomenonsupporting

confidence: 84%

“…It's widely involved in gastritis, asymptomatic for most infected individuals. A small proportion of infected individuals develop more dangerous gastritis involving peptic ulceration and gastric malignancy [22,[25][26][27][28][29][30][31][32][33]. Helicobacter pylori is responsible for tremendous morbidity and mortality throughout the world [6,7,12,[14][15][16].…”

Section: Helicobacter Pylori Infectionmentioning

confidence: 99%

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

NdelodiPhanzu¹,

Malolo²,

Matondo³

et al. 2018

J Pharmacogenomics Pharmacoproteomics

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During the 3 rd Euro case reports in Valencia, Spain, a strange medical case taking place in the DRC has been presented. Indeed, while the Congolese population is, until now, convinced of the existence of massive criminal poisonings, throughout the national area, originating from the East region of the country, we incredibly observed and demonstrated that actually, the phenomenon is a silent, surprising and unexpected Helicobacter pylori epidemic with numerous extra-digestive pathologies. The present subject will deal with picturesque meanders by which our research work passed, lengthening it to more than twenty years before getting appropriate results. The presentation will start by a brief summary of the DRC Helicobacter pylori phenomenon described in Valencia and hypothesis raised for better knowledge of Helicobacter pylori infection, at the international level. In a second time, it will focus on the influence and consequences of some followed factors in our study: HIV infection, political situation in DRC, lack of equipment and financial means, population ignorance, traditional practitioners' cupidity, deficiency of south-North collaboration, and so on. Afterwards, two interesting incredible extra-digestive DRC Helicobacter pylori cases observed in our study will be discussed. Finally a brief conclusion will present some useful propositions drawn from the experience of this DRC Helicobacter pylori research work.

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“…[1][2][3] Infection with H. pylori is a major risk factor for gastric carcinogenesis and, moreover, infection has been directly implicated in the development of atrophy and intestinal metaplasia. 4, 5 A 26.8% prevalence of H. pylori infection has been reported in a group of patients with histologically proven atrophic body gastritis.…”

Section: Introductionmentioning

confidence: 99%

The long‐term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis

Annibale

Giulio

Caruana

et al. 2002

Aliment Pharmacol Ther

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SUMMARYBackground: Helicobacter pylori infection induces atrophic body gastritis, but the long-term effect of its cure on body atrophy is unclear. Aim: To investigate the long-term effects of H. pylori cure on gastric morpho-functional parameters in patients with atrophic body gastritis. Methods: Forty patients with atrophic body gastritis were cured of H. pylori infection. Gastroscopy with biopsies, gastrin and pepsinogen I levels and basal and stimulated acid secretion were evaluated before and 6-12 months after treatment. Results: At eradication assessment (6-12 months), in eight of the 40 patients, body atrophy was no longer observed, whereas in 32 of the 40 it remained substantially unchanged (2.03 ± 0.12 vs. 1.83 ± 0.15). In the eight patients with reversed body atrophy, gastrinaemia

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Helicobacter pylori infection in pernicious anemia: A prospective controlled study

Cited by 138 publications

References 16 publications

Autoimmune Gastropathy in Type 1 Diabetic Patients With Parietal Cell Antibodies

Autoimmune Gastropathy in Type 1 Diabetic Patients With Parietal Cell Antibodies

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases

The long‐term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis

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