Helicobacter pylori Infection in Congestive Gastropathy

A, Bahnacy; Kempler, Péter; Z, Elés; Járay, Balázs; Flautner, L

doi:10.1111/j.1523-5378.1996.tb00033.x

Cited by 16 publications

(8 citation statements)

References 23 publications

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“…This gastric manifestation of portal hypertension is present in up to 50% of cirrhotic patients (20), and accounts for one-third of bleeding events in these patients (21). In the present study, the prevalence of H pylori infection was similar in patients with congestive gastropathy compared with patients without (42% versus 46%), as previously demonstrated (22,23), and peptic ulcer disease was slightly more prevalent among H pylori-infected patients with congestive gastropathy than in infected patients without congestive gastropathy. Overall, observations from the literature seem to indicate that congestive gastropathy and H pylori infection are independent factors that may affect the gastric mucosa.…”

Section: Discussionsupporting

confidence: 89%

Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: The Role ofHelicobacter pyloriInfection and Portal Hypertensive Gastropathy

Dore

Mura²,

Deledda³

et al. 2004

Canadian Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 89%

Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: The Role ofHelicobacter pyloriInfection and Portal Hypertensive Gastropathy

Dore

Mura²,

Deledda³

et al. 2004

Canadian Journal of Gastroenterology

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“…Many studies failed to find a correlation between the severity of PHG and H. pylori infection. [ 24 25 26 ] During advanced gastropathy, the environment for the colonization of H. pylori becomes unfavorable, resulting in a decrease in the number of patients harboring this organism. In our study, the patients harboring H. pylori were of younger age, had higher serum albumin, lower Child Pugh score, and lower portal vein diameter.…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori and its virulence factors on portal hypertensive gastropathy and interleukin (IL)-8, IL-10, and tumor necrosis factor-alpha levels

Abbas

Yakoob

Usman

et al. 2014

Saudi J Gastroenterol

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Background/Aim:We aimed to assess the influence of Helicobacter pylori and its virulent factors, cytotoxin associated gene (cag) A and E, on portal hypertensive gastropathy (PHG) and the levels of interleukin (IL)-8, IL-10, and tumor necrosis factor-alpha (TNF-α).Patients and Methods:The patients with cirrhosis underwent screening endoscopy and the lesions related to PHG were graded. Biopsies were obtained for histology, and polymerase chain reaction (PCR) of H. pylori 16S rRNA, cagA, cagE, and tissue cytokine levels was carried out. Absent or mild PHG was compared with moderate to severe PHG.Results:One hundred and forty patients with cirrhosis were studied; males numbered 92 and the mean age of the patients was 50.3 ± 12.0 years, H. pylori positivity in 87 (62.1%) patients was associated with male gender (P = 0.032), younger age (P = 0.029), hepatitis D etiology (P = 0.005), higher serum albumin (0.000), lower Child Pugh score (P = 0.001), and lower portal vein diameter (P = 0.001). There was no significant difference in the levels of TNF-α and IL-8. However, a decrease in the anti-inflammatory cytokine IL-10 was noted with moderate to severe gastropathy. Four H. pylori strains were positive for both cagA and cagE, while four were positive for cagA only. All the four patients with both virulent factors had mild gastropathy only.Conclusion:The presence of H. pylori infection neither affected the severity of PHG nor augmented the IL-8 and TNF-α levels. There was a decline of virulent H. pylori strains and IL-10 levels in patients with advanced PHG.

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“…Two studies were identified after additional searches. Finally, 13 studies (8 cohort studies and 5 case-control studies) were included in the meta-analysis [10][11][12][13][15][16][17][18][19]24,25]…”

Section: Literature Searchmentioning

confidence: 99%

Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis

Kim

et al. 2022

PLoS ONE

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Despite the importance of Helicobacter pylori infection and portal hypertension (PH)-associated gastrointestinal (GI) diseases, such as esophageal varices and portal hypertensive gastropathy (PHG), the impact of H. pylori infection on PH-related GI complications has not yet been elucidated. This meta-analysis investigated the association between H. pylori infection and the risk of PH-related GI complications. An electronic search for original articles published before May 2020 was performed using PubMed, EMBASE, and the Cochrane Library. Independent reviewers conducted the article screening and data extraction. We used the generic inverse variance method for the meta-analysis, and Begg’s rank correlation test and Egger’s regression test to assess publication bias. A total of 1,148 cases of H. pylori infection and 1,231 uninfected controls were included from 13 studies. H. pylori infection had no significant association with esophageal varices [relative risk (RR) = 0.96, 95% confidence interval (CI) = 0.87–1.06 for all selected studies; RR = 0.95, 95% CI = 0.84–1.07 for cohort studies; odds ratio (OR) = 0.96, 95% CI = 0.60–1.54 for case-control studies]. Although H. pylori infection was significantly associated with PHG in case-control studies [OR = 1.86, 95% CI = 1.17–2.96], no significant differences were found in the cohort studies [RR = 0.98, 95% CI = 0.91–1.05] or all studies combined [RR = 1.18, 95% CI = 0.93–1.52]. In conclusion, H. pylori infection was not associated with the risk of PH-related GI complications. Clinicians should carefully treat cirrhotic patients with PH-related GI complications, regardless of H. pylori infection.

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Helicobacter pylori Infection in Congestive Gastropathy

Abstract: We conclude that the role of H. pylori in the pathogenesis of congestive gastropathy is unlikely, and we suggest that there is no need for its routine eradication in cirrhotic patients.

Cited by 16 publications

References 23 publications

Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: The Role ofHelicobacter pyloriInfection and Portal Hypertensive Gastropathy

Active Peptic Ulcer Disease in Patients with Hepatitis C Virus-Related Cirrhosis: The Role ofHelicobacter pyloriInfection and Portal Hypertensive Gastropathy

Effect of Helicobacter pylori and its virulence factors on portal hypertensive gastropathy and interleukin (IL)-8, IL-10, and tumor necrosis factor-alpha levels

Helicobacter pylori infection is not associated with portal hypertension-related gastrointestinal complications: A meta-analysis

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