Helicobacter pylori  infection in children

Rajindrajith, Shaman; Devanarayana, Niranga Manjuri; Silva, Hithanadura Janaka de

doi:10.4103/1319-3767.48964

Cited by 39 publications

(40 citation statements)

References 95 publications

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“…The presence of IgG antibodies against H. pylori denotes active infection because once an individual is colonized, the infection continues throughout life unless a course of appropriate eradication therapy is instituted (Rajindrajith et al . ).…”

Section: Discussionmentioning

confidence: 97%

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Correlation of serum antibody titres with invasive methods for rapid detection of Helicobacter pylori infections in symptomatic children

Abdulqawi

El-Mahalaway

Abdelhameed

et al. 2012

Int J Experimental Path

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Helicobacter pylori (H. pylori) is causally associated with peptic ulcer disease and gastric carcinoma. Typically, children get infected during the first decade of life, but diseases associated with H. pylori are seen mainly in adults. Multiple diagnostic methods are available for the detection of H. pylori infection. The aim of this study was to evaluate the correlation and diagnostic accuracy of three invasive methods [rapid urease test (RUT), histology and bacterial culture] and one non-invasive method (IgG serology) for diagnosis of H. pylori infection in a prospective cohort study conducted on 50 symptomatic children between two and eighteen years of age. Endoscopies with gastric biopsies were performed for RUT, culture and histopathological examination, respectively. IgG antibodies were measured in patient sera using a commercially available enzyme-linked immunosorbent assay (ELISA). RUT and positive H. pylori IgG antibodies were concordant in 88% (44/50) of patients. Both tests were negative in 32% (16/50), and both were positive in 56% (28/50). Disagreement occurred in 12% (6/50) of the patients: three of them (6%) had positive RUT and negative H. pylori IgG, and another three (6%) had negative RUT and positive H. pylori IgG. A combination of RUT with non-invasive serology constituted the optimum approach to the diagnosis of H. pylori infection in symptomatic children. The non-invasive serological test (ELISA) could not be used alone as the gold standard because it cannot distinguish between active and recently treated infection; and bacterial culture could not be used alone because of its low sensitivity.

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Section: Discussionmentioning

confidence: 97%

“…) and a rapid enzyme immune assay (EIA) to detect H. pylori antigen in stool has been developed (Rajindrajith et al . ). In adults, the stool test has a sensitivity and specificity of 90%.…”

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confidence: 97%

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Correlation of serum antibody titres with invasive methods for rapid detection of Helicobacter pylori infections in symptomatic children

Abdulqawi

El-Mahalaway

Abdelhameed

et al. 2012

Int J Experimental Path

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“…16 Host iron is known to be essential for pathogen growth. 17 However, there have been inconsistent reports on the roles of iron in the acquisition of H. pylori infection. [17][18][19] Perhaps, the iron overload in thalassemia patients might have contributed to the high prevalence of H. pylori infection observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

JMEN

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Introduction: The idea that Helicobacter pylori (H. pylori) might confer benefit to humans by impairing iron absorption has engendered considerable controversy among investigators. The aim of the present study was to compare the seroprevalence of anti H. pylori in asymptomatic beta thalassemia major (β TM) patients and normal controls. Materials and methods: 40 proven adults β TM cases (group 1) and 40 age and sexmatched healthy controls (group 2) were the subject of the study. The mean age of adults' β TM was 21.5±4.97 years. Twenty two (55%) were males and 18 (45%) were females. Serum samples from all patients and controls were examined for specific IgG antibodies to the following H. pylori six virulent antigens: cagA (cytotoxin-associated gene A), vacA (vacuolating cytotoxin A), UreA (urease A), p30 (OMP), p25 (OMP) and p19 (OMP) using H. pylori LINE Immunoblot Assay. Serum samples from all patients were examined also for HCV-RNA viral load by Real Time PCR. Results: There was a statistically significantly higher seroprevalence of H. pylori among adult β TM patients than among the controls [14/40 (35%) vs. 9/40 (22.5%)] respectively (X 2 =82.538, p=0.000). Antibodies against cagA and vacA were absent in the healthy seropositive controls. There was no statistically significant difference between H. pylori IgG-positive (14 cases) and negative (22 cases) β TM as regards age (t=0.633, p=0.432), sex (x 2 =0.175, p=0.676), hemoglobin value (t=0.332, p=0.568), serum ferritin level (t=0.394, p=0.394) and presence of HCV. Antibodies to the six virulent antigens of H. pylori were higher in splenectomized than non splenectomized patients. Antibodies to cagA and vacA were significantly higher in splenectomized than non splenectomized patients (p=0.015 and 0.044 for cagA and vacA respectively). Conclusion: There was higher H. pylori seroprevalence in asymptomatic β-TM cases than among controls, being more frequently in splenectomized than non splenectomized patients. No difference in serum ferritin level between H. pylori seropositive and seronegative cases.

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“…Gastric colonization by Helicobacter pylori occurs in early childhood, often through household exposure 1,2 . Crowded living conditions, poor hygiene, and gastroenteritis facilitate person‐to‐person transmission, and prevalence of infection is greater in developing countries compared to industrialized countries 2 .…”

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confidence: 99%

Remission of high‐grade B‐cell lymphoma in a pediatric patient following Helicobacter pylori eradication

Furaikh¹

2011

Pediatrics International

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A rational approach for assessing the hypothalamo-pituitary-adrenal axis. Lancet 1988; 1(8596): 1208-10. 8 Tuchelt H, Dekker K, Bähr V, Oelkers W. Dose-response relationship between plasma ACTH and serum cortisol in the insulin-hypoglycaemia test in 25 healthy subjects and 109 patients with pituitary disease. Clin. Endocrinol. (Oxf.) 2000; 53: 301-7. 9 Schober E, Frisch H. Growth retardation and reduced growth hormone secretion in a boy with achalasia.

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Helicobacter pylori infection in children

Cited by 39 publications

References 95 publications

Correlation of serum antibody titres with invasive methods for rapid detection of Helicobacter pylori infections in symptomatic children

Correlation of serum antibody titres with invasive methods for rapid detection of Helicobacter pylori infections in symptomatic children

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Remission of high‐grade B‐cell lymphoma in a pediatric patient following Helicobacter pylori eradication

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