Helicobacter pylori Infection in Children with Celiac Disease: Prevalence and Clinicopathologic Features

Luzza, Francesco; Mancuso, M; Imeneo, Maria; Mesuraca, L; Contaldo, A; Giancotti, Luigino Antonio; Vecchia, Anna M. La; Docimo, C; Pensabene, Licia; Strisciuglio, Pietro; Pallone, Francesco; Guandalini, Stefano

doi:10.1097/00005176-199902000-00009

Cited by 49 publications

(42 citation statements)

References 12 publications

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“…We found no positive anti-H. pylori-IgG among the sera from the children with celiac disease identified by the mass screening study [8], which is in agreement with the results of an Italian study of 81 children with celiac disease [22].…”

Section: Discussionsupporting

confidence: 90%

Low prevalence of Helicobacter pylori infection in young children in the Netherlands

Mourad-Baars¹,

Verspaget

Mertens

et al. 2007

European Journal of Gastroenterology & Hepatology

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Section: Discussionsupporting

confidence: 90%

Low prevalence of Helicobacter pylori infection in young children in the Netherlands

Mourad-Baars¹,

Verspaget

Mertens

et al. 2007

European Journal of Gastroenterology & Hepatology

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“…This finding was supported by further studies conducted by Luzza et al in 1999 [15] and Aydogdu et al in 2008 [7]. However, Diamanti et al reported that patients with CD have a significantly lower prevalence of H. pylori infection compared with controls in 1999 [16].…”

Section: Discussionmentioning

confidence: 61%

Relationship between Helicobacter pylori infection and celiac disease: a cross-sectional study and a brief review of the literature

Başyiğit

Ünsal

Uzman

et al. 2017

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IntroductionWhether Helicobacter pylori triggers celiac disease (CD) or protects against CD is currently the subject of research. In the literature, there are epidemiologic studies that have reported conflicting results regarding the association between H. pylori and CD.AimTo compare the prevalence of CD autoantibody positivity and the levels of CD autoantibodies between H. pylori-positive and H. pylori-negative subjects.Material and methodsThis study was prospectively designed and included 240 dyspeptic patients who underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies. The patients were divided into two groups according to presence of H. pylori infection. The serum levels of immunoglobulin (Ig) A, tissue transglutaminase antibodies (tTGA; IgA and IgG classes), and anti-endomysial antibodies (EMA; IgA and IgG classes) were measured for all participants by a blinded biochemistry expert.ResultsThere were no significant differences in the serum levels of CD autoantibodies or IgA between the two groups. There were also no significant differences in the percentages of subjects with positive CD serologies or subjects with IgA deficiencies between the groups.ConclusionsHelicobacter pylori remains one of the bacterial species that is most likely to trigger autoimmunity. However, studies have failed to reveal a relationship between H. pylori and CD; thus, additional basic work on the immunological aspects of the microbial-host interactions and longitudinal studies enrolling patients at very early stages of the disease may help us to address this issue.

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“…The prevalence of Hp infection among 28 CD patients and in patients without CD was 82% and 86.2% respectively. The difference is not statistically significant, according to previous studies by Diamanti et al and Luzza et al that showed a difference in terms of prevalence not statistically significant [27,28,29]. In addition there was no relation between gastritis and severity of mucosal damage in CD.…”

Section: Resultsmentioning

confidence: 74%

Celiac Disease and Helicobacter Pylori Infection: an Ups and Downs Correlation

Pontone¹

2014

Int J Gastroenterol Disord Ther

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Background: Several studies showed an involvement of the gastric mucosa in celiac disease (CD). Helicobacter pylori (Hp) is the major agent of gastric damage. The aim of this article was to present a literature review of a possible correlation between the two conditions. Methods: A literature search was conducted in Medline, Scopus and Directory of Open Access Journal (DOAJ) using appropriate keywords. We included only articles written in English over the period July 1996 -May 2014. Results: The search for Medline, Scopus and DOAJ provided a total of 530 citation. Twenty five studies met the inclusion criteria and were included in quantitative analysis. The prevalence of Hp infection in celiac children and adults from different geographical areas has been reported. The possible correlation between Hp infection and the increase of intraepithelial lymphocytes (IEL) has also been reported. Conclusion: Several studies showed a wide heterogeneity. This is probably due to differences in Hp prevalence, small series of patients, lack of histological confirmation of Hp and lack of adjustment for sociodemographic characteristics. More studies to clarify the possible correlation between these two conditions are necessary.

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Helicobacter pylori Infection in Children with Celiac Disease: Prevalence and Clinicopathologic Features

Abstract: Prevalence and clinical expressivity of H. pylori infection is not increased in children with celiac disease. The clinicopathologic pattern of the infection is not specifically influenced in this condition.

Cited by 49 publications

References 12 publications

Low prevalence of Helicobacter pylori infection in young children in the Netherlands

Low prevalence of Helicobacter pylori infection in young children in the Netherlands

Relationship between Helicobacter pylori infection and celiac disease: a cross-sectional study and a brief review of the literature

Celiac Disease and Helicobacter Pylori Infection: an Ups and Downs Correlation

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