Helicobacter pylori Infection in Children: Recommendations for Diagnosis and Treatment

Gold, Benjamin D.; Colletti, Richard B.; Abbott, Myles B.; Czinn, Steven J.; Elitsur, Yoram; Hassall, Eric; Macarthur, Colin; Snyder, John; Sherman, Philip M.

doi:10.1097/00005176-200011000-00007

Cited by 283 publications

(251 citation statements)

References 56 publications

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“…The studies regarding H pylori were excluded because the literature regarding H pylori had been reviewed recently by a North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition committee and a practice guideline had been published. 11 All titles were reviewed by a single reader (H.P.L. ); 10% of the excluded articles were reviewed by 2 committee members (C.D.L.…”

Section: Methodsmentioning

confidence: 99%

Chronic Abdominal Pain in Children

2005

Pediatrics

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Section: Methodsmentioning

confidence: 99%

Chronic Abdominal Pain in Children

2005

Pediatrics

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“…Patients with only a positive urease rapid test or a positive histology were considered to be in an indeterminate H. pylori status, and were excluded from study analysis. Patients positive for H. pylori received therapy with omeprazole (20 mg once daily), amoxicillin (50 mg/kg per day), and clarithromycin (15 mg/kg per day) for 2 weeks (42). Cure of H. pylori infection was evaluated using the 13C-urea breath test 2 months after the end of therapy.…”

Section: Endoscopymentioning

confidence: 99%

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Pacifico¹,

Anania²,

Osborn³

et al. 2008

European Journal of Endocrinology

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Background: Helicobacter pylori, and the chronic gastric inflammation that it causes, may compromise the function and survival of ghrelin-producing cells, resulting in a decrease of circulating ghrelin levels. This finding raises the possibility that the infection might affect growth in children by reducing the ghrelin production. Aims: To determine baseline circulating levels of ghrelin and leptin in prepubertal children with and without H. pylori infection and to evaluate the long-term effects of H. pylori eradication on circulating levels of ghrelin and leptin as well as on body composition. Patients: Thirty children with H. pylori-associated gastritis, 35 children with H. pylori-negative gastric mucosa, and 20 healthy controls were studied. Results: At baseline, while leptin levels were significantly lower in H. pylori-positive patients, ghrelin concentrations did not differ among the three study groups. However, a significant inverse correlation between ghrelin concentrations and histological severity of gastritis was found. Eradication of the organism was associated with a progressive decrease in ghrelin concentrations over baseline at both 6-and 12-month follow-ups. SDS-body mass index (BMI), lean and fat mass, as well as leptin concentrations, significantly increased over baseline at both follow-ups. Conclusions: In prepubertal children, serum ghrelin concentrations are inversely related to the severity of H. pylori-associated gastritis. In these youngsters, long-term eradication of H. pylori infection is associated with a significant increase in BMI, lean and fat mass along with a significant decrease in circulating ghrelin levels and an increase in leptin levels.

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“…[25][26][27] After the children fasted for Ն1 hour, a baseline breath sample was collected in the manufacturer's breath collection bag. The participant then ingested 3 g of Pranactin-Citric (75 mg of 13 C-urea, citric acid, aspartame, and mannitol) reconstituted in 100 mL of bottled water.…”

Section: Detection Of H Pylorimentioning

confidence: 99%

Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

et al. 2006

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OBJECTIVES. Rural Alaska Natives have a high prevalence of iron deficiency and Helicobacter pylori infection. The objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active H pylori infection among school-aged children in rural Alaska.METHODS. We enrolled 68% (688) of the 7-to 11-year-old children from 10 predominantly Alaska Native villages in southwestern Alaska. We collected venous blood samples to assess iron deficiency and anemia. Each child was tested for active H pylori infection by 13 C-urea breath test (UBT). Evaluated risk factors included age, gender, village of residence, number of household members, number of household members who were younger than 5 years, recent antibiotic use, and household water source.RESULTS. Of 688 enrolled children, iron deficiency was present in 38%, iron-deficiency anemia was present in 7.8%, and H pylori infection by UBT was present in 86%. Iron deficiency was independently associated with living in a household with Ͼ6 people and village of residence. H pylori infection by UBT was independently associated with child's age Ն10 years and village of residence. Ninety-one percent of children with iron deficiency had H pylori infection by UBT, and children with active H pylori infection were more likely to be iron deficient than uninfected children. Children with H pylori infection by UBT were also more likely to have iron-deficiency anemia than uninfected children.CONCLUSIONS. In this study of nearly 700 children in 10 different villages in Alaska, we confirmed that the high prevalence of iron deficiency persists among schoolaged children. We found that active H pylori infection was independently associated with iron deficiency and iron-deficiency anemia among children in this region. H pylori infection may account for a portion of the iron deficiency and iron-deficiency anemia in rural Alaska and other areas with high prevalences of both conditions. Innovative approaches are critically needed to address the iron deficiency in high prevalence areas such as rural Alaska and most of the developing world. Dr Baggett assisted with study design, was the primary person responsible for study implementation during the first study year, conducted all data analysis, and was the primary manuscript author. Dr Gessner was the study primary investigator, wrote the study protocol, was the primary person responsible for study implementation during the second study year, and assisted with data analysis and preparing the manuscript. Dr Parkinson was responsible for all components of laboratory analysis, assisted with study design, and provided critical input into the final manuscript. Ms Muth assisted with study design and writing the study protocol, was the primary person responsible for administrative project management, and reviewed the final manuscript. Dr Gold contributed to the study design, data analysis, and interpretation and provided critical input into the final manuscript. 2 The prevalence of iron deficiency among children...

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Helicobacter pylori Infection in Children: Recommendations for Diagnosis and Treatment

Cited by 283 publications

References 56 publications

Chronic Abdominal Pain in Children

Chronic Abdominal Pain in Children

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

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