Helicobacter pylori infection correlates with severity of reflux esophagitis: with manometry findings

Abstract

The role of Helicobacter pylori infection in the development and exacerbation of reflux esophagitis was investigated. The prevalence of Helicobacter pylori infection, the severity of atrophic gastritis, and esophageal motility (determined by esophageal manometry by an infusion catheter method) were assessed in patients with mild (n = 46) and severe (n = 27) reflux esophagitis and subjects without reflux (n = 28). Compared with the prevalence of Helicobacter pylori infection in the non-reflux group, the prevalence in the mild and severe reflux groups (60.7%, 47.8%, and 14.8%, respectively) was significantly (P < 0.05) lower. Atrophic gastritis was milder in both reflux groups than in the non-reflux group. The degree of gastritis was also milder in the severe reflux group than in the mild reflux group. The esophageal sphincter pressure was significantly (P < 0.05) lower in the reflux groups than in the non-reflux group, and the amplitude of primary peristalsis was significantly (P < 0.05) lower in the severe reflux group than in the non-reflux group. There were no significant differences between reflux patients with and without Helicobacter pylori infection in the parameters of esophageal manometry. These data imply that a low prevalence of Helicobacter pylori infection may result in a milder grade of atrophic gastritis, and consequently, exacerbate reflux esophagitis.

Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradication

“…We verified the development of erosive esophagitis in 19% of them after H. pylori eradication, similarly to RAGHUNATH et al (34) systematic review publication.…”

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

“…Furthermore, although we examined chronological changes in the degree of gastric mucosal atrophy on endoscopy, the status of H. pylori infection was not assessed. H. pylori infection has repeatedly been reported to influence gastric acid secretion and the prevalence of reflux esophagitis (31)(32)(33). Therefore, future studies are required to clarify the effects of timecourse changes in the rate of H. pylori infection on the prevalence of GERD.…”

Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

“…The incidences of RE in patients with disease durations of less than 6 years, 6 to 11 years, 11 to 16 years, and more than 16 years were 11.8% (2/17), 10 respectively. The incidence of RE tended to rise with increased duration of the disease.…”

“…Some investigators have reported that the incidence of H pylori infection in diabetic patients is higher than controls [9][10][11][12][13] . Some investigators have reported that in DM patients, due to impaired immune function and impaired gastrointestinal motility, they were prone to H pylori infection [36][37][38] .…”

“…There are some reports that hiatal hernia, age, H pylori infection and body mass index (BMI) are considered to affect the outbreak of RE [7,8] . Recent studies have reported that H pylori infection was less prevalent in patients with RE than those without RE, and was considered to suppress the onset of RE by inducing gastric mucosal atrophy and lowering gastric acid secretion [9,10] . Some investigators have reported that the incidence of H pylori infection in diabetic patients is higher than controls [11][12][13][14] , though other investigators have reported no such significant differences between these groups [15,16] .…”