Helicobacter Pylori Infection; Comparison of Stool Antigen Test and Histology of  Endoscopic Biopsy for Diagnosis

Qadir, Adnan; Younis, Irfan; Khalid, B.; Butt, Zamir; Sarwar, Shahid

doi:10.17957/tpmj/16.3531

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Similar findings were noted in studies done by Baqai et al, 17 with sensitivity and specificity of 65% and 76% respectively. Sensitivity and specificity were low in a study done by Siddiqui et al, 2010, 18 20 respectively, and they suggested it to be the best non-invasive test for H.pylori detection.…”

Section: Discussionmentioning

confidence: 93%

Comparison of Stool Antigen Test with Histopathology of Endoscopic Gastric Biopsies for Detection for Helicobacter Pylori; A Hospital-Based Study

Zubair

Nawaid

Afridi

et al. 2022

PAFMJ

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Objective: The objective of this study is to evaluate the diagnostic accuracy of H. pylori Stool Antigen (HpSA) test keeping histopathology as gold standard. Study Design: This is a cross sectional observational study. Place and Duration: This study was performed from Jan 2015 to Mar 2020 at Najran Armed Forces Hospital, kingdom of Saudi Arabia. Methodology: Total 151 patients in whom HpSA was done were included in the study. They were followed for their results of histopathology on gastric biopsies. Results: Among 151 patients 85(56.3%) were females and 66 (43.7%) were males. Mean age was 40 years. Forty three (28.5%) patients were positive for both HpSA and on histology, Fifteen (9.9%) patients were positive on HpSA test but negative on histology. Twenty two (14.6%) patients were negative on HpSA but they were positive on histology. Seventy one (47%) patients were negative both on HpSA and histology. The sensitivity and specificity were 66.1% and 82.5% respectively. Positive predictive value (PPV) was 74.1% and negative predictive value (NPV) was 76.3% for HpSA. Diagnostic accuracy for this test was 75.5%. Conclusion: Keeping in view the low sensitivity and diagnostic accuracy HpSA test cannot be used as screening tool in all patients, however it can be used for clinical correlation in setups where other diagnostic tests are not available due to the simplicity of its use, low cost and easy repeatability

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Section: Discussionmentioning

confidence: 93%

Comparison of Stool Antigen Test with Histopathology of Endoscopic Gastric Biopsies for Detection for Helicobacter Pylori; A Hospital-Based Study

Zubair

Nawaid

Afridi

et al. 2022

PAFMJ

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“…But in the study was done by Osman et al (17) there were 36 (61%) males and (39%) females. Also in the study had done by Qadir et al (15) that composed of 110 patients, among them 80 were males (72.2%) and 30 females (27.27%) that difference may be attributable to the nonrandomization in sample selection.…”

Section: Discussionmentioning

confidence: 96%

“…However, the endoscopist's level of expertise, the quantity, location, and size of biopsies taken, as well as the staining and the pathologist's interpretation of the results, are all variables that might affect the accuracy of the diagnosis. While it is generally accepted that histopathology is the best method for detecting H. pylori, its application in clinical practice may be limited by factors such as its high cost, the lack of an adequate endoscope, and the lack of appropriately trained personnel (15) . This research set out to assess the effectiveness of routinely prescribed antibiotics against Helicobacter pylori and to evaluate the reliability of a diagnostic stool antigen test administered following medical therapy for H. pylori.…”

Section: Discussionmentioning

confidence: 99%

Upper Endoscopy Biopsy Versus Helicobacter Pylori Antigen in Stool Test in Evaluation of Helicobacter Pylori Infection

El-Ennen¹,

Galal²,

Alghonaimy³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Infection with the bacteria Helicobacter pylori is frequent in both young and old. Antibiotic susceptibility testing on an individual or community level, as well as data on antibiotic use and clinical outcomes, should inform the most effective local regimen for eradication. Objective: The aim of the current work was to evaluate the efficacy of commonly used antibiotics against Helicobacter pylori and to determine diagnostic stool antigen test accuracy performed after H. pylori medical treatment. Patients and Methods: This prospective single arm cohort study included a total of 55 patients who tested positive for H. pylori, followed at Departments of Tropical Medicine and Pathology, Zagazig University Hospitals. This study was conducted between July 2020 and January 2021. Results: H. pylori infection was more common in middle age group 32.6±8.58 and more in female (56.4%). The most frequent presentations were dyspepsia (63.6%), epigastric pain (23.6%) and abdominal fullness 12.7% of the cases. Gastritis 49.1%, duodenitis 32.7%, gastric ulcer 12.7% and duodenal ulcer 10.9%, are the common endoscopic diagnosis in H. pylori infection. After therapy, there was a moderate statistically significant agreement between biopsy and stool in diagnosis of H. pylori infection with sensitivity 90%, but specificity 73.3% and accuracy 76.4%. Conclusion:It could be concluded that Helicobacter Pylori stool antigen test is highly sensitive with moderate specificity and accuracy for diagnosis of H. pylori infection post anti H. pylori therapy.

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Helicobacter Pylori Infection; Comparison of Stool Antigen Test and Histology of Endoscopic Biopsy for Diagnosis

Cited by 2 publications

References 5 publications

Comparison of Stool Antigen Test with Histopathology of Endoscopic Gastric Biopsies for Detection for Helicobacter Pylori; A Hospital-Based Study

Comparison of Stool Antigen Test with Histopathology of Endoscopic Gastric Biopsies for Detection for Helicobacter Pylori; A Hospital-Based Study

Upper Endoscopy Biopsy Versus Helicobacter Pylori Antigen in Stool Test in Evaluation of Helicobacter Pylori Infection

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