Helicobacter Pylori Infection: Association with Hashimoto’s Thyroiditis

Korani, Mohamed

doi:10.15406/ghoa.2016.04.00111

Cited by 3 publications

(1 citation statement)

References 22 publications

(21 reference statements)

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“…This could subsequently damage the thyroid tissues, thus increasing the disorder's progression. Our results were consistent and were confirmed by a local study (Aboud, 2011) in addition to other regional and international studies (Aghili et al,2013;Shi et al,2013;Korani et al,2016). Otherwise, Bassi et al concluded that the correlation between H. pylori and autoimmune thyroid diseases was found only with Graves's disease and not Hashimoto's.…”

Section: Discussionsupporting

confidence: 92%

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

2022

JJBS

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The association of different infections with the subsequent occurrence of autoimmunity, just like autoimmune thyroiditis, has recently been increased globally. This study aimed to determine the role of Helicobacter pylori (HP) infection in Hashimoto's disease. The research groups involved 50 patients with Hashimoto's disease and 50 healthy subjects. All of them were subjected to the estimation of concentrations of free triiodothyronine (FT3), free thyroxine (FT4), TSH, antithyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg). In addition, for the diagnosis of HP, IgG, as well as anti-CagA antibodies in the serum, were detected. An independent t-test was used to test the significance of the means. Also, an odd ratio was used to clarify the association between H. pylori infection and HT disease. Statistical significance was detected when P-value is equal to or less than 0.05. The results indicated that 94% of Hashimoto's patients and 34% of the healthy subjects were seropositive for HP IgG. Also, (74%) of the HT patients were seropositive for HP IgG/anti-CagA. These results were significant at the level of 0.01 (p< 0.001). Hashimoto's patients with HP/CagA positive tests have significantly elevated concentrations of anti-TPO (480.69±311.29), anti-Tg (336.00±175.95), and TSH (20.43±18.98) compared with patients tested negatively to HP/CagA antibodies (358.60±281.55, 258.36±170.09 and 9.02±5.94 respectively). In conclusion, there is a relationship between H. pylori infection and the development of Hashimotoʼs thyroiditis in Iraqi patients. H. pylori infection, especially CagA expressing strains, could be a risk factor for the development of autoimmune hypothyroidism and to a lesser extent its progression by increasing the concentration of thyroid antibodies and TSH, which in turn leads to decreased levels of the thyroid hormones and worsening of the disease, requesting antibiotic therapy to eradicate the bacterial infection.

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Section: Discussionsupporting

confidence: 92%

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

2022

JJBS

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Helicobacter pylori-induced autoimmune thyroiditis: is the pathogenic link concluded or still a hypothesis?

Thiyagarajan¹,

Saini²,

Alruwaili

2018

Reviews in Medical Microbiology

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Infection caused by Helicobacter pylori is considered as a serious health issue as it can cause severe damage of gastric mucosa, impair the digestive mechanism and even lead to neoplastic disease. Research studies have projected its survival in many parts of the body beyond the gastric system. The ability of these bacteria to withstand the gastric juice and change the surrounding conditions makes its survival in the stomach successful. As an outcome of H. pylori infection, there occurs the release of inflammatory mediators and immune modulators, which could cause further complications. Recent investigations on H. pylori have demonstrated the association of its infection with many systemic diseases including lung cancer, urticaria, type-1 diabetes, autoimmune diseases and so on. Autoimmune thyroiditis (AIT) is an organ-specific autoimmune disease, which occurs as a result of production of autoantibodies to thyroid gland leading to thyroid dysfunction. Antibodies of similar kind produced against H. pylori have been demonstrated for their occurrence in patients suffering with AIT in many studies. On the other hand, some of the studies have experimentally proved the lack of link between H. pylori infection and AIT. As the findings attributing H. pylori infection with the AIT are increasingly reported in recent years, this article reviews the concepts and controversies over their association.

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Prevalence of undiagnosed thyroid dysfunction in correlation with Helicobacter pylori infection: cross-talk between Hashimoto’s thyroiditis and Helicobacter pylori

Rashad

Gomaa

2019

Egypt J Intern Med

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Background Worldwide, the prevalence of thyroid dysfunction is increasing and it is one of the leading endocrine disorders. The objective of the present study was to assess the prevalence of undiagnosed thyroid dysfunction and its association with Helicobacter pylori (HP) infection and to clarify the association between HP and Hashimoto’s thyroiditis. Patients and methods A cross-sectional study was conducted among 300 unrelated patients; 187 patients had normal thyroid function and 113 patients had thyroid dysfunction. The patients were stratified into one of the following five groups based on the reference of the normal thyroid function test; thyroid-stimulating hormone and free thyroxine were used as the screening tests to diagnose thyroid dysfunction. HP antigen in the stool and antibodies against cytotoxin-associated gene A (cag-A), anti-thyroid peroxidase (anti-TPO) antibodies, and anti-thyroglobulin (anti-TG) antibodies were measured. Results Our results show that the prevalence of thyroid dysfunction was found in 37.6% of the studied population. The most frequent dysfunction was subclinical hypothyroidism (44.4%), followed by overt hypothyroidism (20.6%). Interestingly, the prevalence was higher in association with HP infection diagnosed by HP antigen and cag-A antibodies. There was statistically significant positive correlation between HP antigen and anti-TPO as well as anti-TG. Regarding cag-A. There were statistically significant positive correlations between antibodies against cag-A and anti-TG as well as anti-TPO. Interestingly, stepwise linear regression analysis showed that serum thyroid-stimulating hormone levels were independently correlated with free thyroxine, HP. Conclusion The higher prevalence of thyroid dysfunction as observed in the current study was associated with Hashimoto’s thyroiditis. Further future multicenter studies with a bigger sample size are needed to validate our findings.

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Helicobacter Pylori Infection: Association with Hashimoto’s Thyroiditis

Cited by 3 publications

References 22 publications

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

Incidence of Helicobacter pylori Infection among Hashimoto's Thyroiditis Patients in Amara City, Iraq

Helicobacter pylori-induced autoimmune thyroiditis: is the pathogenic link concluded or still a hypothesis?

Prevalence of undiagnosed thyroid dysfunction in correlation with Helicobacter pylori infection: cross-talk between Hashimoto’s thyroiditis and Helicobacter pylori

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