Helicobacter pylori infection associated with type 2 diabetic nephropathy in patients with dyspeptic symptoms

Zhou, Fei; Zhong, Xiaoqin; Li, Chunguo; Shang, Ming; Jiang, Cheng; Yang, Haojin; Zhao, Wei‐Dong; Liu, Liqiu

doi:10.1016/j.diabres.2015.09.008

Cited by 22 publications

(17 citation statements)

References 30 publications

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“…Furthermore, the H. pylori infection rate was significantly higher in patients with T2DM and DPG than in those without DPG, suggesting that patients with T2DM with H. pylori infection are more likely to develop the clinical manifestations of gastroparesis. The higher H. pylori infection rate in patients with diabetes may be explained by the following mechanisms:[ 7 8 9 10 11 ] (1) diabetes-related deficiencies in cellular and humoral immunity can increase H. pylori susceptibility; (2) mechanical and potential changes in the stomach due to diabetic autonomic neuropathy may lower the gastric mucosa's ability to remove bacteria; and (3) in patients with diabetes, nonenzymatic mucin glycosylation can increase salivary mucin in the gastric mucosa and thus promote the binding of H. pylori with the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Huang

2017

Chinese Medical Journal

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Background:Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP.Methods:In this study, 163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP, simple diabetes, non-DGP (NDG), and normal groups based on their conditions. The H. pylori infection rate in each group was calculated. H. pylori eradication therapy was performed for patients with H. pylori infection in each group. The eradication rates were compared between the groups, and the improvements in gastroparesis-associated symptoms were compared before and after treatment in patients with DGP.Results:The H. pylori infection rate was 74.6% in the DGP group, which was significantly higher than that in the simple diabetes (51.1%, P < 0.01), NDG (57.7%, P < 0.05), and normal groups (48.0%, P < 0.01). With increased disease course, the incidence of DGP and the H. pylori infection rate gradually increased (P < 0.05). In the DGP group, the incidences of upper abdominal pain and distention, early satiety, and anorexia were 75.5%, 66.0%, and 67.9%, respectively, before eradication treatment; and 43.4%, 35.8%, and 39.6%, respectively, after eradication treatment, and the difference was statistically significant (P < 0.01). In patients with DGP with successful H. pylori eradication, the number of barium strips discharged after eradication was 5.9 ± 1.0, which was significantly larger than that before treatment (4.1 ± 0.7, P < 0.01). In addition, the number of barium strips discharged was significantly larger in patients with DGP with successful H. pylori eradication than those with failed H. pylori eradication (P < 0.01).Conclusions:DGP development might be associated with H. pylori infection. H. pylori eradication can effectively improve dyspepsia-associated symptoms and delayed gastric emptying in patients with DGP.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Huang

2017

Chinese Medical Journal

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“…Also, several crosssectional studies have shown a significant statistical association between H. pylori and diabetes [3,15]. However, some studies in this regard have shown that there is no significant association between diabetes and prevalence H. pylori infection [2,16,17].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

et al. 2020

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Background: There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus. Methods: A systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990-March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case-control studies were analyzed using odds ratio (OR) with 95% confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis. Results: A total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR = 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population, Conclusion: In overall a positive association between H. pylori infection and diabetes mellitus was found.

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“…However, Tamura et al found a significantly higher DM prevalence among individuals with H. pylori infection than those without, but the difference could be mostly ascribed to older age [ 13 ]. And some studies argued that no difference in the prevalence of H. pylori infection was found between DM and non-DM individuals [ 14 , 15 ]. Overall, this subject remains controversial now.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pyloriInfection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis

Jun-zhen

et al. 2017

Gastroenterology Research and Practice

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Background Extragastric manifestations of Helicobacter pylori (H. pylori) infection have been reported in many diseases. However, there are still controversies about whether H. pylori infection is associated with diabetes mellitus (DM). This study was aimed at answering the question. Methods A systematic search of the literature from January 1996 to January 2016 was conducted in PubMed, Embase databases, Cochrane Library, Google Scholar, Wanfang Data, China national knowledge database, and SinoMed. Published studies reporting H. pylori infection in both DM and non-DM individuals were recruited. Results 79 studies with 57,397 individuals were included in this meta-analysis. The prevalence of H. pylori infection in DM group (54.9%) was significantly higher than that (47.5%) in non-DM group (OR = 1.69, P < 0.001). The difference was significant in comparison between type 2 DM group and non-DM group (OR = 2.05), but not in that between type 1 DM group and non-DM group (OR = 1.23, 95% CI: 0.77–1.96, P = 0.38). Conclusion Our meta-analysis suggested that there is significantly higher prevalence of H. pylori infection in DM patients as compared to non-DM individuals. And the difference is associated with type 2 DM but not type 1 DM.

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Helicobacter pylori infection associated with type 2 diabetic nephropathy in patients with dyspeptic symptoms

Cited by 22 publications

References 30 publications

Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

Helicobacter pylori infection as a risk factor for diabetes: a meta-analysis of case-control studies

Helicobacter pyloriInfection Is Associated with Type 2 Diabetes, Not Type 1 Diabetes: An Updated Meta-Analysis

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