Helicobacter pylori Infection and the Risk of Gastric Malignancy

Hsu, Ping‐I; Lai, Kwok‐Hung; Hsu, Ping I.; Lo, Gin‐Ho; Yu, Hsien‐Chung; Chen, Wen‐Chi; Tsay, Feng‐Woei; Lin, Hui-Chen; Tseng, Hui‐Hwa; Ger, Luo‐Ping; Chen, Hui‐Chun

doi:10.1111/j.1572-0241.2006.01109.x

Cited by 94 publications

(84 citation statements)

References 22 publications

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“…The frequency of H pylori infection (94.4%) was higher than previous studies, where it ranged from 34.1% to 92%. These differences can be due to: (a) the sensitivity of the screening technique, since most previous studies used serology, rapid urease test and/or histological evaluation; (b) and the fact that these studies were performed in different world regions and it is known that the H pylori infection is more frequent in developing countries [8,16,[22][23][24] . On the other hand, EBV was detected in 8.45% of our cases.…”

Section: Discussionmentioning

confidence: 99%

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Lima

Lima²,

André³

et al. 2008

WJG

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AIM: To investigate the interrelationship betweenH pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression.METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS:The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P = 0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori .However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION:The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

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Section: Discussionmentioning

confidence: 99%

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Lima

Lima²,

André³

et al. 2008

WJG

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“…In addition, many other inflammatory triggers are associated with other malignancies, including microbial infection, such as Helicobacter pylori infection, associated with gastric cancer, autoimmune responses associated with inflammatory bowel disease and colorectal cancer and sexualtransmitted infections with prostatitis and prostate cancer [65][66][67].…”

Section: Cancer and Ageingmentioning

confidence: 99%

Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement

Candore

Caruso

Jirillo³

et al. 2010

CPD

123

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Nowadays, people are living much longer than they used to do, however they are not free from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and individuals, is a post-maturational process that, due to a diminished homeostasis and increased organism frailty, causes a reduction of the response to environmental stimuli and, in general, is associated to an increased predisposition to illness and death. However, the high incidence of death due to infectious, cardiovascular and cancer diseases underlies a common feature in these pathologies that is represented by dysregulation of both instructive and innate immunity. Several studies show that a low-grade systemic inflammation characterizes ageing and that inflammatory markers are significant predictors of mortality in old humans. This pro-inflammatory status of the elderly underlies biological mechanisms responsible for physical function decline and agerelated diseases such as Alzheimer's disease and atherosclerosis are initiated or worsened by systemic inflammation. Understanding of the ageing process should have a prominent role in new strategies for extending the health old population. Accordingly, as extensively discussed in the review and in the accompanying related papers, investigating ageing pathophysiology, particularly disentangling agerelated low grade inflammation, is likely to provide important clues about how to develop drugs that can slow or delay ageing.

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“…Similarly, in a small cohort study, in which H. pylori status was ascertained by histological examination, rapid urease test, and serologic test, 3% of infected subjects but none of the uninfected developed a stomach cancer, after a mean followup time of 7.8 years [25]. Another study conducted in Taiwan with a similar study design also reported none of stomach malignancies detected among the uninfected subjects after a mean follow-up of 6.3 years [26].…”

Section: Discussionmentioning

confidence: 78%

976 H. pylori Seropositivity Before Age 40 and Subsequent Risk of Stomach Cancer: A Glimpse of the True Relationship?

Persson¹,

Jia²,

Pettersson³

et al. 2009

Gastroenterology

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Helicobacter pylori Infection and the Risk of Gastric Malignancy

Cited by 94 publications

References 22 publications

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression

Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement

976 H. pylori Seropositivity Before Age 40 and Subsequent Risk of Stomach Cancer: A Glimpse of the True Relationship?

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