Helicobacter pylori infection and prevalence of high blood pressure among Chinese adults

Abstract

Epidemiological studies demonstrated that Helicobacter pylori (H. pylori) infection was associated with cardiovascular disease and its risk factors. However, the association between H. pylori infection and hypertension remained unclear. The aim of this study was to investigate the association between H. pylori infection and prevalence of hypertension among Chinese adults. We performed a cross-sectional study of 5246 adult participants who were recruited from a health manage center. All participants underwent a C-urea breath test and a routine health check-up. Logistic and liner regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for hypertension in relation to H. pylori infection. Of the 5168 study participants aged 18-70 years, 2034 (39.4%) were females and 955 (18.5%) had hypertension. After adjustment for potential confounders, H. pylori infection was associated with an increased prevalence of hypertension (OR, 1.23; 95% CI, 1.04, 1.46). In addition, compared with participants not infected with H. pylori, those with H. pylori infection had an increase of 0.735 mmHg (95% CI, 0.101, 1.369) for diastolic blood pressure and 0.723 mmHg (95% CI, 0.034, 1.413) for mean arterial pressure. There was no significant interaction between H. pylori infection and age, sex, and body mass index on the prevalence of hypertension (all P values for interaction>0.05). Findings from this study demonstrate that H. pylori infection was positively associated with prevalence of hypertension among Chinese adults. More well-designed studies are warranted to confirm our findings.

Helicobacter pylori infection and the prevalence of hypertension in Chinese adults: The Dongfeng‐Tongji cohort

“…A large‐scale, community‐based study in an Iranian population indicated that H pylori infection showed a significant association with hypertension by testing for immunoglobulin G (IgG) antibodies 17 . The results of a cross‐sectional study performed by Wan et al 9 were consistent with our findings. In contrast with the results of our study, Hartog et al 18 tested for H pylori using antibodies among 440 Dutch, 320 Turkish, and 272 Moroccan participants and found that H pylori infection was weakly associated with hypertension but was not statistically significant.…”

“…However, we found that H pylori infection was related to a higher DBP but not SBP, PP, and MAP. A cross‐sectional study indicated that H pylori infection was positively associated with DBP but not SBP 9 . Meanwhile, Migneco et al 13 demonstrated a significant decrease in DBP after H pylori eradication in hypertensive patients.…”

“…As the correlation between H pylori infection and parenteral diseases is becoming increasingly confirmed, more studies related to hypertension are being conducted. Some studies have shown that H. p ylori is positively correlated with the risk of hypertension 9 . However, Tang et al 10 showed that after adjusting for confounding factors, H pylori infection was not associated with hypertension.…”

The diagnostic values of circulating miRNAs for hypertension and bioinformatics analysis

“…However, little has been done to identify the association of osteoclast differentiation and neurotrophin signaling pathway with hypertension. There were also three ways participating in infection, such as toxoplasmosis [ 31 ], pertussis [ 32 ], epithelial cell signaling in Helicobacter pylori infection [ 33 ], which have been proved to be related with hypertension, while pathways involving hepatitis B and tuberculosis have not been proved to be associated with hypertension. However, mechanisms of those pathways interacted with hypertension remains to be investigated.…”

Review:Helicobacter pyloriand extragastric diseases

“…Another study, enrolling 5246 Chinese patients, reported a 32.6% prevalence of H pylori infection using UBT, and the presence of a concomitant blood hypertension in 955. H pylori infection was significantly associated with hypertension, even after adjusting the data for possible confounders, such as age, sex, and other cardiovascular risk factors …”