Helicobacter pylori infection and gastric cardia cancer in Chaoshan region

Wang, Yunsheng; Liu, Shuhui; Zhang, Ying; Bi, Chao; Xiao, Yinping; Lin, Runhua; Huang, Bo; Tian, Dan; Ying, Songmin; Shu, Min

doi:10.1016/j.micinf.2014.06.009

Cited by 15 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reason for a higher incidence of CGCs in countries within this geographic area in Central Asia is unknown; however, it has been noted that high-risk populations may have a high prevalence of certain risk factors for CGC such as obesity and GORD 33 34. Furthermore, given a high prevalence of H pylori infection in countries within Central Asia,35 36 and the disparate influence of risk factors for CGC across some populations,12 17 18 it is also possible that H pylori infection may contribute to high rates of CGC in these populations.…”

Section: Discussionmentioning

confidence: 99%

“…NCGC, however, is strongly associated with Helicobacter pylori infection 13 14. Some evidence suggests that H pylori infection may be inversely associated with both oesophageal adenocarcinoma and CGC,15 16 though studies in some populations have suggested a positive association between the bacterium and CGC 12 17 18. The influence of socioeconomic status (SES) also differs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Global patterns of cardia and non-cardia gastric cancer incidence in 2012

Colquhoun

Arnold

Ferlay

et al. 2015

Gut

299

268

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Global patterns of cardia and non-cardia gastric cancer incidence in 2012

Colquhoun

Arnold

Ferlay

et al. 2015

Gut

299

268

View full text Add to dashboard Cite

show abstract

“…However, in our previous paper, we performed a combined analysis of a large cohort of GCC patient samples, from the Chaoshan area, to additionally demonstrate an association between H. pylori infection and risk of cardia gastric cancer, [3]. In Chaoshan, 81.5% of GCC tumors are infected with H. pylori , which is significantly higher than the 59% incidence of tumor infection in GCC patients in other parts of China [31], suggesting H. pylori infection correlates with the risk of cardia gastric cancer. However, this conclusion is not without controversy due to some studies describing an inverse relationship between H. pylori infection and gastric cardia cancer, especially in Western countries [32, 33].…”

Section: Discussionmentioning

confidence: 99%

Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation

Zhang

Wang

et al. 2016

Oncotarget

Self Cite

View full text Add to dashboard Cite

BackgroundGastric cardia cancer (GCC) is located in the distal stomach, and strongly correlates with atrophic gastritis and Helicobacter pylori(H.pylori) infection. Caudal-related homeobox transcription factor 2 (CDX2) is homeobox gene encoding an intestine-specific transcription factor usually expressed in the intestinal epithelium cells. However, in several recent published papers, CDX2 was found to be aberrantly expressed in gastric, thyroid and ovarian cancer.ResultsHigher expression of CDX2 was found in GCC tissues in comparison with non-malignant cardia mucosa (p<0.05). Moreover, immunohistochemical analysis demonstrated that CDX2 expression correlated with lymphatic metastasis. In addition, we found that CDX2 expression progressively increased with the level of H. pylori infection (p<0.05), and also correlated with cell proliferation, based on Ki67 staining.MethodsTo investigate the relationship between CDX2, cell proliferation and H. pylori infection, we detected CDX2, Ki62 and H.pylori expression in 83 non-malignant gastric cardia mucosacases and 60 GCC specimens in the Chaoshan area, a high-risk region for esophageal and gastric cardia cancer.ConclusionThese findings provide pathological evidence that H. pylori infectionis a driving force of gastric cardia carcinogenesis by upregulating CDX2 and inducing inflammation. These results provide new pathological evidence that H. pylori infection induces GCC tumorigenesis.

show abstract

“…The association between cardiac inflammation and EAC is unclear, and most cases are associated with BE [27], [28], [29]. Because inflammation and OS are strongly linked, in this study, we evaluated whether OS is present and estimated the antioxidant capacity of the proximal stomach of patients with BE and EAC.…”

Section: Introductionmentioning

confidence: 99%

Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett’s Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction

Kauppi

Räsänen

Sihvo

et al. 2016

Translational Oncology

View full text Add to dashboard Cite

OBJECTIVES: Oxidative stress (OS) is an essential element in the pathogenesis of Barrett’s esophagus (BE) and its transformation to adenocarcinoma (EAC). The state of OS in the proximal stomach of patients with BE and EAC is unknown. Isoprostanes are a specific marker of OS not previously used to determine OS from BE/EAC tissue samples. PATIENTS AND METHODS: OS was measured in 42 patients with BE (n = 9), EAC (n = 9), or both (n = 24) and 15 control patients. A STAT-8-Isoprostane EIA Kit served to identify 8-Isoprostanes (8-IP), and a Glutathione Assay Kit was used to measure glutathione reduced form (GSH) and glutathione oxidized form. An OxiSelect Oxidative DNA Damage ELISA Kit (8-OHdG) served to measure 8-OH-deoxyguanosine. RESULTS: The 8-IP (P = .039) and 8-OHdG (P = .008) levels were higher, and the GSH level lower (P = .031), in the proximal stomach of the study group than in that of the controls. Helicobacter pylori infection was present in 8% of the study patients. CONCLUSIONS: In the proximal stomach of BE and EAC patients, OS was elevated and antioxidative capacity was reduced. This finding suggests that the gastroesophageal reflux causing BE also induces oxidative stress in the proximal stomach and may contribute to the development of cancer in the proximal stomach and gastric cardia.

show abstract

Helicobacter pylori infection and gastric cardia cancer in Chaoshan region

Cited by 15 publications

References 21 publications

Global patterns of cardia and non-cardia gastric cancer incidence in 2012

Global patterns of cardia and non-cardia gastric cancer incidence in 2012

Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation

Increased Oxidative Stress in the Proximal Stomach of Patients with Barrett’s Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction

Contact Info

Product

Resources

About