Helicobacter pylori infection and chronic gastric acid hyposecretion

El-Omar, Emad; Oien, Karin A.; El-Nujumi, A.; Gillen, Derek; Wirz, Angela A.; Dahill, Stephen; Williams, Craig; Ardill, Joy; McColl, Kenneth E.L.

doi:10.1016/s0016-5085(97)70075-1

Cited by 561 publications

(480 citation statements)

References 2 publications

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“…Many investigators, including our group, consistently reported that the suppressed gastric acid secretion in H. pylori-positive patients with corpus gastritis with or without atrophy recovered at least partially after eradication of the infection (El-Omar et al 1997;Tucci et al 1998;Iijima et al 2004). In this context, employing Congo-red chromoendoscopy, which is known to be capable of visualizing the acid-secreting fundic area by means of a pH-dependent color reaction (Tatsuta et al 1973), we found that the area of the acid-secreting mucosa in the fundus was promptly expanded after eradication, especially in the greater curvature (Sekine et al 2006).…”

mentioning

confidence: 75%

Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas

Iijima

Abe

Koike

et al. 2012

Tohoku J. Exp. Med.

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Although Helicobacter pylori (H. pylori) eradication has some inhibitory effects on the subsequent development of gastric cancer, there are sporadic cases of gastric cancer even after successful eradication. The pathogenesis of gastric cancer emerging after H. pylori eradication remains to be clarified. In this study, employing Congo-red chromoendoscopy, which is capable of visualizing the acid-secreting fundic mucosa, we investigated the topographic relationship of the acid secretion pattern to the occurrence site of gastric cancers emerging after eradication. Fourteen consecutive patients who suffered from new gastric cancer after eradication, defined as lesions that were discovered at least 2 years after the eradication, were prospectively enrolled. Whether the neoplasias arose from acid-secreting or nonacid-secreting areas was evaluated with Congo-red chromoendoscopy. Biopsy specimens taken from the two areas were subjected to histologic evaluation and immunohistochemistry for Ki-67 and p53. The mean period from the eradication to the subsequent occurrence of gastric cancer was 74 (44) months. There were two cancer lesions in 5 cases, and thus there was a total 19 lesions from 14 cases. Congo-red chromoendoscopy revealed that all 19 lesions arose exclusively from non-acid-secreting areas. Histological examination revealed sustained hyperproliferation and accumulation of p53 protein was frequently detectable in non-acid-secreting areas. Genetic alteration such as p53 mutation seems to be already present in the residual non-acid-secreting areas after eradication, areas that could be the origin of gastric carcinogenesis after eradication. Identification of such high-risk areas should be a promising approach for estimating the individual cancer risk after eradication.

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mentioning

confidence: 75%

Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas

Iijima

Abe

Koike

et al. 2012

Tohoku J. Exp. Med.

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“…[4] (1 + 3%) 15 Although the discount rate and the length of time affect the future cancer costs in a non-linear fashion, their neteffect amounts to a reduction in cancer costs. In terms of Figure 2.…”

Section: Results Of the Analyses Using The Decision Treementioning

confidence: 99%

Medical decision models of Helicobacter pylori therapy to prevent gastric cancer

Sonnenberg

Inadomi

1998

Aliment Pharmacol Ther

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tration on its essential features. A model would defy its very purpose if it tried to be overly detailed and simulate the medical phenomenon by considering all influences that occur in the real world. A good model should be simple and easily appreciated. Classic examples of elegant and conceptually simple mathematical models are, for instance, the differential equations that were developed by mathematicians to describe the complex and seemingly bewildering phenomena of physics. The majority of problems encountered in medicine, unfortunately, involve too many interrelated variables to be summarized in such a fashion. In essence, linear and logistic regression analyses represent two types of mathematic tools to model the influence of multiple variables on one medical outcome of interest. Compartment models and path

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“…Within a few years, this thinking was turned on its head by the discovery that H. pylori was responsible for the gastric acid hypersecretion in duodenal ulcer disease via impaired antral somatostatin secretion and exaggerated gastrin release [12,13]. Gastric acid hyposecretion may also result from H. pylori infection [14], with the net effect on acid secretion depending upon Fig. 1 The growth of scientific knowledge of H. pylori, 1983-2012.…”

Section: Gastric Acid Secretionmentioning

confidence: 99%

“…A wealth of research since has confirmed that link, with a surfeit of mechanistic data (including the discovery of the H. pylori gene product CagA, a unique bacterial oncoprotein), the development of animal models of H. pyloriinduced cancer, and even some, albeit underpowered, [16,17,34] Other adverse effects of H. pylori A cause of idiopathic thrombocytopenic purpura and (especially in children), obscure iron-deficiency anemia [35,36]. Associated with stunted growth and low IQ in the developing world [37] Whole genome sequencing One of the first genomes to be completely sequenced, enhancing knowledge of H. pylori biology and pathogenesis, with implications for drug and vaccine development [38] Gastric physiology, function and cell turnover Examining the effects of H. pylori eradication improved our understanding of somatostatin/gastrin/gastric acid secretion and regulation [12][13][14] among other aspects of gastric biology, including physiology, microscopic histopathology, cell biology and immunology [21,39] Human evolution Probing the genomic diversity of H. pylori among human populations has informed knowledge of human evolutionary history and migration patterns [40]. The coexistence of mammals with Helicobacter species is widespread, demonstrating an ancient and probably mutually beneficial, relationship…”

Section: Gastric Cancermentioning

confidence: 99%

The Rediscovery of H. pylori Bacteria in the Gastric Mucosa by Robin Warren, and Implications of this Finding for Human Biology and Disease

Moss

2013

Dig Dis Sci

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Helicobacter pylori infection and chronic gastric acid hyposecretion

Cited by 561 publications

References 2 publications

Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas

Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas

Medical decision models of Helicobacter pylori therapy to prevent gastric cancer

The Rediscovery of H. pylori Bacteria in the Gastric Mucosa by Robin Warren, and Implications of this Finding for Human Biology and Disease

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