Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin

Lanas, Ángel; Fuentes, Javier; Benito, Rafael; Bajador, Eduardo; Serrano, Pedro; Sainz, Ricardo Calle

doi:10.1016/s0016-5085(00)83081-4

Cited by 53 publications

(50 citation statements)

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“…38,91,92 In a case-control study of 695 consecutive users of low-dose ASA with upper GI bleeding, H pylori infection was identified as an independent risk factor of upper GI bleeding (OR 4.7; 95% CI: 2.0 to 10.9). Other risk factors identified were a previous ulcer history (OR 15.2; 95% CI: 3.8 to 60.1), alcohol use (OR 4.2; 95% CI: 1.7 to 10.4), and use of calcium-channel blockers (OR 2.54; 95% CI: 1.25 to 5.14).…”

Section: Role Of H Pylorimentioning

confidence: 99%

“…Other risk factors identified were a previous ulcer history (OR 15.2; 95% CI: 3.8 to 60.1), alcohol use (OR 4.2; 95% CI: 1.7 to 10.4), and use of calcium-channel blockers (OR 2.54; 95% CI: 1.25 to 5.14). 91 Whether eradication of H pylori infection in patients with a history of ulcer prior to starting ASA will reduce subsequent ulcer risk has been controversial. In a 6-month randomized trial of H pylori eradication versus maintenance therapy with omeprazole in ASA users with H pylori infection and a recent history of ulcer bleeding (nϭ250), rates of recurrent ulcer bleeding were comparable between the 2 treatment groups (1.9% in the eradication therapy group and 0.9% in the omeprazole group; 95% CI for the difference: Ϫ1.9% to 3.9%).…”

Section: Role Of H Pylorimentioning

confidence: 99%

See 1 more Smart Citation

ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

Bhatt¹,

Scheiman²,

Abraham³

et al. 2008

Circulation

578

200

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Section: Role Of H Pylorimentioning

confidence: 99%

Section: Role Of H Pylorimentioning

confidence: 99%

ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use

Bhatt¹,

Scheiman²,

Abraham³

et al. 2008

Circulation

578

200

View full text Add to dashboard Cite

“…Gastrointestinal bleeding risk in aspirin users is increased in H pylori infected patients (OR = 4.7) and those with a history of ulcers (OR = 15.2) (117,158) . Eradicating H pylori as the primary prevention role prior to using aspirin is not well established in all patients, but it is reasonable and justifiable in patients with other risk factors for ulcers and digestive bleeding (118) .…”

Section: Statement 24mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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“…For example, in a recent placebo-controlled, double-blind, randomized prospective trial, patients receiving low-dose aspirin who had H pylori infection had significantly worse gastric mucosal injury than uninfected patients [56]. Two other studies [57,58] suggest that H pylori infection may increase the risk of clinically significant gastrointestinal events, including bleeding. Eradication of H pylori infection may reduce the risk of gastrointestinal bleeding associated with NSAID or aspirin use.…”

Section: Nsaid Ulcersmentioning

confidence: 99%