Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis

Zhou, Qinghua; Li, Ren-Qing

doi:10.1111/j.1600-0714.2011.01006.x

Cited by 84 publications

(65 citation statements)

References 29 publications

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“…Some PCR studies found H. pylori DNA in samples from oral cavities, but overall, reports of live H. pylori are very rare and inconclusive [33] . In light of this literature review, we agree with Zou and Li [34] and their report that H. pylori can be identified unequivocally only through the use of direct cultures. This limitation exists because erroneous PCR results can result from the presence of transient H. pylori in…”

Section: Root Canals and Oral Mucosasupporting

confidence: 89%

Helicobacter pyloriand its reservoirs: A correlation with the gastric infection

Payão

Rasmussen

2016

WJGPT

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Helicobacter pylori (H. pylori ) has long been found to cause gastric diseases such as gastritis, gastric ulcers and gastric cancer. The transmission medium of this bacterium has yet to be determined, though several studies have speculated that the oral cavity is a reservoir for H. pylori . Others have also reported that the oral cavity may be a source of both transmission and gastric reinfection; however, such results are controversial. We reviewed the literature and selected studies that report an association among H. pylori detections in the oral cavity (dental plaque, saliva, tongue, tonsil tissue, root canals, oral mucosa) in humans and in animals, as well as in the human stomach. The oral cavity may be considered the main reservoir for H. pylori . There are a correlations between H. pylori infection in the oral cavity and periodontal disease, oral tissue inflammation, H. pylori transmission, and gastric reinfection. We believe that the mouth is a reservoir and that it plays a crucial role in both H. pylori transmission and gastric infection.

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Section: Root Canals and Oral Mucosasupporting

confidence: 89%

Helicobacter pyloriand its reservoirs: A correlation with the gastric infection

Payão

Rasmussen

2016

WJGPT

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“…However, there are some problems with this treatment, such as patient compliance, antibiotic resistance, and high cost, resulting in relapse after a short period in about 15% to 30% of patients (9)(10)(11)(12). There is some evidence of the presence of H. pylori in the oral cavity, which a recent meta-analysis related to gastric colonization and possible reinfection (13,14). The presence of H. pylori in tonsils is controversial (15)(16)(17); if confirmed, it could help further understanding of H. pylori transmission and reinfection.…”

mentioning

confidence: 99%

Oral Immunization with Recombinant Lactobacillus acidophilus Expressing the Adhesin Hp0410 of Helicobacter pylori Induces Mucosal and Systemic Immune Responses

Fan¹,

Wu²,

Fang³

et al. 2013

Clin. Vaccine Immunol.

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Helicobacter pylori infection is relatively common worldwide and is closely related to gastric mucosa-associated lymphoid tissue (MALT) lymphoma, chronic gastritis, and stomach ulcers. Therefore, a safe and effective method for preventing H. pylori infection is urgently needed. Given that developing an effective vaccine against H. pylori is one of the best alternatives, H. pylori adhesin Hp0410 was expressed in the food-grade bacterium Lactobacillus acidophilus. The recombinant live bacterial vaccine was then used to orally vaccinate mice, and the immunoprotective effects of Hp0410-producing strains were investigated. H. pylori colonization in the stomach of mice immunized with the recombinant L. acidophilus was significantly reduced, in comparison with that in control groups. Furthermore, mucosal secretory IgA antibodies were elicited in the mucosal tissue of mice immunized with the recombinant bacteria, and specific anti-Hp0410 IgG responses were also detected in mouse serum. There was a significant increase in the level of protection against gastric Helicobacter infection following a challenge with H. pylori Sydney strain 1 (SS1). Our results collectively indicate that adhesin Hp0410 is a promising candidate vaccine antigen, and recombinant L. acidophilus expressing Hp0410 is likely to constitute an effective, low-cost, live bacterial vaccine against H. pylori.

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“…Varios estudios han demostrado la presencia de H. pylori simultáneamente en cavidad oral y mucosa gástrica, mostrando diferentes prevalencias, dependiendo de la población estudiada, la selección de la muestra y técnicas de detección de la bacteria [26][27][28][29][30][31][32][33]40 . Mapstone 41 , demostró que la presencia de H. pylori en la boca de pacientes dispépticos es importante para su diseminación y considera la cavidad oral una potencial fuente de reinfección luego de la erradicación del microorganismo del estómago.…”

Section: Discussionunclassified

“…Algunos autores han encontrado una asociación entre la presencia de H. pylori en mucosa gástrica y oral [26][27][28][29][30][31][32][33] . En una investigación previa realizada por nuestro grupo, se observó la co-existencia de la bacteria en ambas localizaciones mediante RPC en tiempo real (RPC-TR) 34 .…”

Section: +16unclassified