Helicobacter pylori iceA, Clinical Outcomes, and Correlation with cagA: A Meta-Analysis

Abstract

BackgroundAlthough the iceA (induced by contact with epithelium) allelic types of Helicobacter pylori have been reported to be associated with peptic ulcer, the importance of iceA on clinical outcomes based on subsequent studies is controversial. The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with iceA.MethodsA literature search was performed using the PubMed and EMBASE databases for articles published through April 2011. Published case-control studies examining the relationship between iceA and clinical outcomes (gastritis, peptic ulcer, including gastric ulcer and duodenal ulcer, and gastric cancer) were included.ResultsFifty studies with a total of 5,357 patients were identified in the search. Infection with iceA1-positive H. pylori increased the overall risk for peptic ulcer by 1.26-fold (95% confidence interval [CI], 1.09–1.45). However, the test for heterogeneity was significant among these studies. Sensitivity analysis showed that the presence of iceA1 was significantly associated with peptic ulcer (odds ratio [OR] = 1.25, 95% CI = 1.08–1.44). The presence of iceA2 was inversely associated with peptic ulcer (OR = 0.76, 95% CI = 0.65–0.89). The presence of iceA was not associated with gastric cancer. Most studies examined the cagA status; however, only 15 studies examined the correlation and only 2 showed a positive correlation between the presence of cagA and iceA1.ConclusionOur meta-analysis confirmed the importance of the presence of iceA for peptic ulcer, although the significance was marginal.

Correlation of Helicobacter pylori Genotypes with Gastric Histopathology in the Central Region of a South-European Country

“…In our study, population iceA2 subtype was the dominant one, as previously stated for Western patients [7,11,20,22]. The relationship of iceA with gastric histopathology and clinical presentation is also very different from study to study [13,20,45].…”

“…Expression of iceA1 is upregulated on contact of H. pylori with human epithelial cells and may be linked with peptic ulcer disease [11].…”

Helicobacter pylori cag Pathogenicity Island cagL and orf17 Genotypes Predict Risk of Peptic Ulcerations but not Gastric Cancer in Iran

“…H. pylori has several virulence factors that might take part in mucosal damage (Mahdavi et al, 2002;Erzin et al, 2006;Kusters et al, 2006;Miernyk et al, 2011;Yeh et al, 2011;Shiota et al, 2012). This study investigated the relevance of various virulence factors (cagH, cagL, cagG, and orf17) and their relationship with sever gastrointestinal disease.…”

Prevalence of Helicobacter pylori genotypes in patients with gastroduodenal pathology in Kazan

“…Раз-личают две аллельные формы этого гена -iceA1 и iceA2. Известно, что iceA1 чаще ас-социирован с язвенной болезнью, iceA2 -с развитием хронического гастрита [7][8][9][10].…”

“…Эти показатели оказались ниже, чем у взрослых, среди которых iceA1 встречался в 55,2% случаев (32 пациента), что в значительной мере согласуется с по-лученными ранее в нашем регионе резуль-татами [20], а также с литературными дан-ными [7][8][9][10].…”