Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma

Jala, Isabelle; Almanfaluthi, Muhammad Luthfi; Laha, Thewarach; Kanthawong, Sakawrat; Tangkawattana, Sirikachorn; Saichua, Prasert; Suttiprapa, Sutas; Sripa, Banchob

doi:10.3347/kjp.2021.59.4.363

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Opisthorchis viverrini infections lead to hepatobiliary manifestations, including advanced periductal fibrosis (APF), which is correlated with the risk of cholangiocarcinoma. The existing literature proposes that a carcinogenic bacterium, Helicobacter pylori ( H. pylori ), also contributes to the development of cholangiocarcinoma by enhancing the severity of hepatobiliary abnormalities [ 67 ]. A study by Hang et al found that even after completion of therapy with praziquantel, patients with co-infection by H. pylori , especially cagA-positive strain, continued to have persistent APF [ 68 ].…”

Section: Treatmentmentioning

confidence: 99%

Opisthorchis viverrini—Current Understanding of the Neglected Hepatobiliary Parasite

Liau,

Toh,

Shelat

2023

Pathogens

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Opisthorchiasis due to Opisthorchis viverrini infection continues to be a significant public healthcare concern in various subregions of Southeast Asia, particularly in Thailand, Laos, Cambodia, Myanmar, and Vietnam. The main mode of transmission is via consumption of raw or undercooked fish, which is deeply embedded in the culture and tradition of the people living near the Mekong River. After ingestion, the flukes migrate to the bile ducts, potentially causing many hepatobiliary complications, including cholangitis, cholecystitis, cholelithiasis, advanced periductal fibrosis and cholangiocarcinoma. Several mechanisms of opisthorchiasis-associated cholangiocarcinogenesis have been proposed and elucidated in the past decade, providing insight and potential drug targets to prevent the development of the sinister complication. The gold standard for diagnosing opisthorchiasis is still via stool microscopy, but the advent of novel serological, antigen, and molecular tests shows promise as more convenient, alternative diagnostic methods. The mainstay of treatment of opisthorchiasis is praziquantel, while treatment of opisthorchiasis-associated cholangiocarcinoma depends on its anatomic subtype and resectability. Thus far, the most successful fluke control programme is the Lawa model based in Thailand, which raised awareness, incorporated education, and frequent surveillance of intermediate hosts to reduce transmission of opisthorchiasis. Development of vaccines using tetraspanins shows promise and is currently ongoing.

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Section: Treatmentmentioning

confidence: 99%

Opisthorchis viverrini—Current Understanding of the Neglected Hepatobiliary Parasite

Liau,

Toh,

Shelat

2023

Pathogens

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“…Intestinal helminthiases play a significant role in the observed undernutrition prevalence [9]. Furthermore, heavy and chronic infection with O. viverrini may cause severe hepatobiliary morbidity, including cholangiocarcinoma, a fatal bile cancer [15][16][17]. Severe hepato-splenic morbidity is associated to chronic S. mekongi infection.…”

Section: Introductionmentioning

confidence: 99%

Intestinal helminth infections and associated risk factors among adults in the Lao People’s Democratic Republic

Phonekeo,

Kounnavong,

Vonglokham

et al. 2023

Infect Dis Poverty

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Background Helminthiases are highly endemic in Southeast Asia, including the Lao People's Democratic Republic (Lao PDR). This study aimed to assess the current intestinal helminth infections and the associated risk factors among adults across the Lao PDR. Methods A cross-sectional survey was conducted in 165 villages across 17 provinces and the Vientiane Capital, Lao PDR. A multi-stage sampling method was employed to select the adult study participants (≥ 18 years). Data collection included (1) interview of the study participants, (2) physical measurements, and (3) a five gram of stool sample from each study participant was collected and preserved in 10% formalin solution for intestinal helminth detection using formalin-ether concentration technique (FECT). Descriptive analysis was used to describe the socio-demographic characteristics of study participants and the prevalence of intestinal helminth infections. Logistic regressions were applied to test the association between intestinal helminth infection and individual risk factors. A P-value below 0.05 was considered statistically significant. Results A total of 2800 study participants were enrolled. Their average age was 46.0 years; 57.8% were female. Overall, 30.9%, 8.6% and 1.5% of study participants were infected with one, two, or three different intestinal helminth species, respectively. Among the study participants 21.6% were infected with hookworm, 18.8% with Opisthorchis viverrini-like (Ov-like) infection, 4.8% with Strongyloides stercoralis, 2.3% with Ascaris lumbricoides, 1.5% with Trichuris trichiura, and 3.3% with Taenia spp. Ov-like infection was of high prevalence in the southern (28.8%) and central (21.3%) provinces, while hookworm (26.3%), A. lumbricoides (7.3%), T. trichiura (3.1%), and Taenia spp. (4.2%) were prevalent in the northern provinces. Risk analysis showed that men were more likely to be infected with hookworm [adjusted odds ratio (aOR) = 1.2, P = 0.019]. The Lao-Tai ethnic group had a 5.2-times (P < 0.001) higher chance of having Ov-like infection than the minorities. Possession of toilet facility at home was associated with reduced odds for Ov-like (aOR = 0.4, P < 0.001) and hookworm (aOR = 0.6, P < 0.001) infections. Conclusions Our study provides a nationwide update of the intestinal helminth prevalence among adults in Lao PDR. To the best of our knowledge, this is the first Lao nationwide survey on intestinal helminth infections and risk factors in adults. It provides crucial information for national control programs for intestinal helminth infections in Lao PDR. Graphical abstract

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“…Infection with O. viverrini is acquired through the consumption of traditional dishes prepared with raw or insu ciently cooked cyprinoid sh [20,21]. Heavy and chronic infection is associated with severe hepatobiliary morbidity, including the fatal bile duct cancer (cholangiocarcinoma) [22][23][24]. Today, small-scale studies of intervention using a chemotherapy-based approach have been conducted in the high endemic areas to explore the feasibility of control programs and provide evidence-based information for policy making and adaption.…”

Section: Introductionmentioning

confidence: 99%

Helminth infections and associated risk factors among adults in the Lao People’s Democratic Republic

Sayasone

Phonekeo

Vonglokham

et al. 2022

Preprint

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Background Helminthiases are highly endemic in Southeast Asia including the Lao People's Democratic Republic (Lao PDR). This study aimed to assess the current helminth infections prevalence among adults across Lao PDR and the associated risk factors. Methods A cross-sectional survey was conducted in 165 villages across 17 provinces and the Vientiane Capital, Lao PDR. A multi-stage sampling method was employed to select the adult study participants (≥ 18 years). Data collection followed the World Health Organization’s stepwise approach, which includes (i) the interview of the study participants, (ii) the physical assessments, and (iii) the stool sample collection. Analysis included the description of socio-demographic characteristics and infection status of helminth infections. Logistic regressions were applied to test the association between helminth infections and individual risk factors. A P-value below 0.05 was considered statistically significant. Results From 2,800 enrolled study participants, 57.8% were female. Average age was 45.4 years. Fecal analysis detected Opisthorchis viverrini in 18.8%, hookworm in 21.6% Strongyloides in 4.8%, Ascaris lumbricoides in 2.3%, Trichuris trichiura in 1.5% of and Taenia sp. in 3.3% of study participants. O. viverrini was of high prevalence in the southern (28.8%) and central (21.3%), while hookworm (26.3%), A. lumbricoides (7.3%), T. trichiura (3.1%), and Taenia spp. (4.2%) were prevalent in the northern provinces. Multiple logistic regression analysis showed that males were more likely to be infected with hookworm (adjusted odds ratio [aOR] = 1.2; 95% confidence interval [CI]: 1.1–1.4). The Lao-Tai ethnic group had a 5.2-times (95% CI: 4.6–5.8) higher chance of having O. viverrini infections than the minorities. Possession of the toilet facility at home prevented helminth infections, e.g., O. viverrini (aOR = 0.4, 95% CI: 0.3–0.5), hookworm (aOR = 0.6, 95% CI: 0.5–0.7), S. stercoralis (aOR = 0.6, 95% CI: 0.5–0.7), A. lumbricoides (aOR = 0.7, 95% CI: 0.6–0.8), T. trichiura (aOR = 0.7, 95% CI: 0.6–0.8), and Taenia spp. (aOR = 0.5, 95% CI: 0.4–0.7). Conclusions Our study provides the first nationwide assessment of intestinal helminth infection among adults in Lao PDR. It provides critical information for guidance to the national helminth control program in Lao PDR.

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Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma

Cited by 7 publications

References 23 publications

Opisthorchis viverrini—Current Understanding of the Neglected Hepatobiliary Parasite

Opisthorchis viverrini—Current Understanding of the Neglected Hepatobiliary Parasite

Intestinal helminth infections and associated risk factors among adults in the Lao People’s Democratic Republic

Helminth infections and associated risk factors among adults in the Lao People’s Democratic Republic

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