Helicobacter pylori genotypes can predict gastric tissue histopathology: A longitudinal study of Iranian patients

Khedmat, Hossein; Karami, Ali; Safiri, Zahra; Amini, Mohsen; Bakhtiari, Ali Shojaee; Karbasi, Ashraf; Jayhounian, Mojgan; Jalalian, Hamid Reza; Taheri, Saeed

doi:10.1016/j.jiph.2011.10.009

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…The progress of disease seems to depend on bacterial genotypes, host and environmental factors. Some studies have reported a significant correlation between H. pylori genotypes and gastric histological damages [17-19]; whilst others reported a variability of genotypes distribution according to nationalities or geographical area [20]. To our knowledge, this is the first study conducted in North Africa and in Morocco on the association of H. pylori genotypes with gastric histological profiles.…”

Section: Discussionmentioning

confidence: 95%

Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population

et al. 2013

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H. pylori persistent infection induces chronic gastritis and is associated with peptic ulcer disease and gastric carcinoma development. The severity of these diseases is related to human’s genetic diversity, H. pylori genetic variability and environmental factors. To identify the prevalence of histo-pathological damages caused by H. pylori infection in Moroccan population, and to determine their association to H. pylori genotypes, a prospective study has been conducted during 3 years on patients attending the gastroenterology department of Hassan II University Hospital (CHU) of Fez, Morocco. A total of 801 Moroccan adults’ patients were recruited; H. pylori was diagnosed and genotyped by PCR in biopsy specimens and histological exam was performed. We found a high rate of glandular atrophy. Chronic inflammation, neutrophil activity and glandular atrophy showed statistically significant association with H. pylori infection. However, intestinal metaplasia was inversely associated to this infection and no association was observed with gastric cancer cases. A statistically significant association was found between intestinal metaplasia and vacAs1 and vac Am1 genotypes in patients aged 50 years and more but not in younger. This last genotype is also associated to gastric cancer. In this study, gastric cancer showed no significant association with H. pylori. Further studies are warranted to determine the role of other etiological agents such as Epstein-Barr virus, human papillomavirus and possibly environmental and dietetic factors in the occurrence of this pathology.

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Section: Discussionmentioning

confidence: 95%

Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population

et al. 2013

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Impaired cholesterol efflux capacity in patients with Helicobacter pylori infection and its relation with inflammation

Fallah

Marsche

Mohamadinarab

et al. 2021

Journal of Clinical Lipidology

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Diagnosis ofHelicobacter pyloriUsing Invasive and Noninvasive Approaches

Abadi

2018

Journal of Pathogens

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Helicobacter pylori (H. pylori) as gram-negative and spiral microorganism is responsible for colonization in the gastric microniche for more than 50% of world population. Recent studies have shown a critical role of H. pylori in the development of peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Over the past decade, there has been a sharp interest to use noninvasive tests in diagnosis of the H. pylori infection. During the years after discovery by Marshall and Warren, it has been frequently declared that the rapid urease test (RUT) is one of the cheapest and rapid diagnostic approaches used in detecting the infection. Although the specificity and sensitivity are durable for this test, clinical experiences had shown that the ideal results are only achieved only if we take biopsies from both corpus and antrum at the same time. Given the diagnosis of the H. pylori in clinical samples, gastroenterologists are facing a long list of various molecular and nonmolecular tests. We need more in-depth researches and investigations to correctly generalize rapid and accurate molecular tests determining both bacterial identity and antibiotic resistance profile.

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Helicobacter pylori genotypes can predict gastric tissue histopathology: A longitudinal study of Iranian patients

Cited by 4 publications

References 28 publications

Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population

Helicobacter pylori Genotypes Associated with Gastric Histo-Pathological Damages in a Moroccan Population

Impaired cholesterol efflux capacity in patients with Helicobacter pylori infection and its relation with inflammation

Diagnosis ofHelicobacter pyloriUsing Invasive and Noninvasive Approaches

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