Helicobacter pylori genotypes associated with gastric cancer and dysplasia in Colombian patients

Carlosama-Rosero, Yeison Harvey; Acosta, Claudia; Sierra‐Torres, Carlos H.; Bolaños-Bravo, H.

doi:10.1016/j.rgmxen.2021.09.003

Cited by 12 publications

(7 citation statements)

References 26 publications

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“…Phosphorylated activated CagA interacts with a variety of host proteins in target cells and continuously activates the abnormal expression of multiple carcinogenic signaling pathways ( Yong et al., 2015 ). Likewise, the risk of gastric cardia and non-cardia adenocarcinoma is much higher in CagA-positive HP infection than in CagA-negative infection ( Carlosama-Rosero et al., 2021 ). VacA can not only induce vacuolization of gastric epithelial cells, but also stimulate apoptosis ( Polk and Peek, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Cross-talk between Helicobacter pylori and gastric cancer: a scientometric analysis

Yang,

Hao,

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundHelicobacter pylori (HP) is considered a leading risk factor for gastric cancer (GC). The aim of this article is to conduct bibliometric and visual analysis to assess scientific output, identify highly cited papers, summarize current knowledge, and explore recent hotspots and trends in HP/GC research.MethodsA bibliographic search was conducted on October 24, 2023, to retrieve relevant studies on HP/GC research between 2003 and 2022. The search terms were attached to HP and GC. The main data were from the Web of Science Core Collection (WoSCC). Data visualization was performed using Biblioshiny, VOSviewer, and Microsoft Excel.ResultsIn HP/GC research, 1970 papers were retrieved. The total number of papers (Np) in HP/GC was growing from 2003 to 2022. China and Japan were in the leading position and made the most contributions to HP/GC. Vanderbilt University and the US Department of Veterans Affairs had the highest Np. The most productive authors were Peek Jr Richard M. and Piazuelo M Blanca. Helicobacter received the most Np, while Gastroenterology had the most total citations (TC). High-cited publications and keyword clustering were used to identify the current status and trends in HP/GC research, while historical citation analysis provided insight into the evolution of HP/GC research. The hot topics included the effect of HP on gastric tumorigenesis and progression, the pathogenesis of HP-induced GC (HP factors), and the mechanisms by which HP affects GC (host factors). Research in the coming years could focus on topics such as autophagy, gut microbiota, immunotherapy, exosomes, epithelial-mesenchymal transition (EMT), and gamma-glutamyl transpeptidase (GGT).ConclusionThis study evaluated the global scientific output in HP/GC research and its quantitative characteristics, identified the essential works, and collected information on the current status, main focuses and emerging trends in HP/GC research to provide academics with guidance for future paths.

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Section: Discussionmentioning

confidence: 99%

Cross-talk between Helicobacter pylori and gastric cancer: a scientometric analysis

Yang,

Hao,

et al. 2024

Front. Cell. Infect. Microbiol.

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“…In a study, we previously reported the association between vacA s1m1 genotype (OR: 6.18; CI: 1.25–30.51; p =0.025) in patients older than 50 years with pathological diagnosis of gastric cancer (dysplasia and gastric cancer) compared with patients with chronic nonatrophic gastritis [ 54 ]. Unlike this, the present research explores the risk of H. pylori genotypes and sociodemographic factors from early preneoplastic lesions (atrophy, intestinal metaplasia).…”

Section: Discussionmentioning

confidence: 99%

Virulence Genes of Helicobacter pylori Increase the Risk of Premalignant Gastric Lesions in a Colombian Population

Carlosama-Rosero

Acosta

Sierra‐Torres

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Background. Genetic variability of Helicobacter pylori is associated with various gastrointestinal diseases; however, little is known about interaction with sociodemographic in the development of premalignant lesions in Colombian patients. Methods. An analytical study was conducted including cases (patients with gastric atrophy, intestinal metaplasia, and gastric dysplasia) and controls (patients with nonatrophic gastritis). Sociodemographic information was obtained using a questionnaire. Histopathological diagnosis was performed according to the Sydney System. The cagA and vacA genotypes were established using polymerase chain reaction in paraffin blocks. The effect of each variable on the study outcome (premalignant lesion) is presented as odds ratio (OR) and 95% CI. A p value of <0.05 was considered as statistically significant. Results. The vacA/s1m1 genotype increases the risk of developing premalignant lesions of the stomach (OR: 3.05, 95% IC: 1.57–5.91, p = 0.001 ). Age and educational level showed a positive interaction with the s1m1 genotype (adjusted OR: 3.68, 95% CI: 1.73–7.82, p = 0.001 ). The cagA genotype was not correlated to the development of premalignant lesions of the stomach (OR: 1.32, 95% CI: 0.90–1.94, p = 0.151 ). Conclusions. The vacA genotype, age, and educational level are indicators of the risk of developing premalignant lesions of the stomach in the study population. Significance Statement. Genetic variability of H. pylori and sociodemographic information could be used to predict the risk of premalignant lesions in stomach in Colombian population.

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“…The fact that some H. pylori-infected patients develop gastric cancer has been associated with some genotypes of the bacterium, such as the CagA+ and VacA/s1m1 genotypes. Therefore, it is believed that the genetic variability of H. pylori favors the appearance of neoplasia (Rosero et al, 2022). Furthermore, the bacterium strains have become increasingly resistant to antibiotics, which makes their eradication in patients difficult and facilitates the process leading to the development of gastric cancer (Sharifi et al, 2017).…”

Section: Helicobacter Pylorimentioning

confidence: 99%

Gastric cancer in the northern region and its possible risk factors: a quantitative analysis of deaths from 2015 to 2019 in Brazil

Fonseca,

Rossi,

Vasconcelos

et al. 2024

Revista Científica Multidisciplinar Núcleo do Conhecimento

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Gastric cancer (GC) is gaining importance in Brazil due to the quantitative increase in the pathology in the population. The main risk factors evidenced by epidemiological studies are genetic and environmental factors, mainly the country’s characteristic diet, rich in foods high in sodium and starch. Additionally, the consumption of alcoholic beverages and smoking, as well as infection caused by the bacterium Helicobacter pylori, which is related to pathological processes of the stomach that can lead to the development of gastric GC, are highlighted. Thus, the present study concluded that the Northern region of Brazil is the most affected by this type of GC compared to other regions of the country, due to the predominance of risk factors in this locality and the high rates of stomach GC registered during the period analyzed by the present study.

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Helicobacter pylori genotypes associated with gastric cancer and dysplasia in Colombian patients

Cited by 12 publications

References 26 publications

Cross-talk between Helicobacter pylori and gastric cancer: a scientometric analysis

Cross-talk between Helicobacter pylori and gastric cancer: a scientometric analysis

Virulence Genes of Helicobacter pylori Increase the Risk of Premalignant Gastric Lesions in a Colombian Population

Gastric cancer in the northern region and its possible risk factors: a quantitative analysis of deaths from 2015 to 2019 in Brazil

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