Helicobacter pylori genotypes and types of gastritis in first-degree relatives of gastric cancer patients

Siavoshi, Farideh; Asgharzadeh, Akbar Ali; Ghadiri, Hamed; Massarrat, Sadegh; Latifi‐Navid, Saeid; Zamani, Mojtaba

doi:10.1016/j.ijmm.2011.03.002

Cited by 10 publications

(5 citation statements)

References 46 publications

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“…Of 213 H. pylori isolates from dyspeptic patients, 149 (69.9%) carried the cagA gene. The prevalence of cagA gene in this study is almost similar to the pattern observed in previous studies in Iran [22,38,[41][42][43]. Several studies have shown the association of cagA with GC or PUD risk in Iran, Iraq, Turkey, Spain, and Portugal [20,22,38,44,45].…”

supporting

confidence: 89%

Relevance of Helicobacter pylori vacA 3ʹ‐end Region Polymorphism to Gastric Cancer

et al. 2015

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supporting

confidence: 89%

Relevance of Helicobacter pylori vacA 3ʹ‐end Region Polymorphism to Gastric Cancer

et al. 2015

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“…In this study, H. pylori isolates from FDR mainly carried the highest virulent vacA s1i1mx genotype combined with a stable CagPAI. A similar vacA haplotype distribution was also evidenced in the D group, consistent with previous results obtained in studies conducted on similar cohorts [42,43]. For the first time, we assessed the presence of hom genes in FDR and AG populations.…”

Section: Discussionsupporting

confidence: 88%

“…Subjects with a family history of GC or affected by autoimmune gastritis (AG) displayed a 1.5–3.0 fold higher risk to develop GC when compared to the general population [39,40,41] and in these individuals H. pylori is a recognized causative agent of gastritis. However, the importance of H. pylori virulence factors, along with conditions such as being First Degree Relatives (FDR) or having AG, which could increase the risk of GC development, has been little explored in non-endemic areas [42,43,44,45,46,47].…”

Section: Introductionmentioning

confidence: 99%

Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk

et al. 2019

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Helicobacter pylori (H. pylori) represents an independent risk factor for Gastric Cancer (GC). First Degree Relatives (FDR) of GC subjects and Autoimmune Gastritis (AG) patients are both at increased risk for GC. H. pylori genetic heterogeneity within the gastric niche of FDR and AG individuals has been little explored. To understand whether they exploit an increased H. pylori stability and virulence, 14 AG, 25 FDR, 39 GC and 13 dyspeptic patients (D) were investigated by a cultural PCR-based approach characterizing single colonies-forming-units. We chose three loci within the Cytotoxin-associated gene-A Pathogenicity Island (CagPAI) (cagA,cagE,virB11), vacA, homA and homB as markers of virulence with reported association to GC. Inflammatory/precancerous lesions were staged according to Sydney System. When compared to D, FDR, similarly to GC patients, were associated to higher atrophy (OR = 6.29; 95% CI:1.23–31.96 in FDR; OR = 7.50; 95% CI:1.67–33.72 in GC) and a lower frequency of mixed infections (OR = 0.16; 95% CI:0.03–0.81 in FDR; OR = 0.10; 95% CI:0.02–0.48 in GC). FDR presented also an increased neutrophil infiltration (OR = 7.19; 95% CI:1.16–44.65). Both FDR and GC carried a higher proportion of CagPAI+vacAs1i1mx+homB+ profiles (OR = 2.71; 95% CI: 1.66–4.41 and OR = 3.43; 95% CI: 2.16–5.44, respectively). Conversely, AG patients presented a lower frequency of subtypes carrying a stable CagPAI and vacAs1i1mx. These results underline different H. pylori plasticity in FDR and AG individuals, and thus, a different host-bacterium interaction capacity that should be considered in the context of eradication therapies.

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“…In contrast, it has been reported that H. pylori genotypes such as vacA s1 cagA might not be important determinants of the type and advanced form of gastritis in the first-degree relatives of gastric cancer patients [47]. Therefore, further comprehensive research is needed.…”

Section: Family History As a Risk Factor For Gastric Cancermentioning

confidence: 99%

Gastric cancer and family history

Choi

Kim

2016

Korean J Intern Med

132

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Gastric cancer is associated with high morbidity and mortality rates worldwide. Identifying individuals at high risk is important for surveillance and prevention of gastric cancer. Having first-degree relatives diagnosed with gastric cancer is a strong and consistent risk factor for gastric cancer, but the pathogenic mechanisms behind this familial aggregation are unclear. Against this background, we reviewed the risk factors for gastric cancer in those with a first-degree relative with gastric cancer, and the possible causes for familial clustering of gastric cancer including bacterial factors, inherited genetic susceptibility, environmental factors or a combination thereof. Among individuals with a family history, current or past Helicobacter pylori infection, having two or more first-degree affected relatives or female gender was associated with an increased risk of developing gastric cancer. To date, no specific single nucleotide polymorphism has been shown to be associated with familial clustering of gastric cancer. H. pylori eradication is the most important strategy for preventing gastric cancer in first-degree relatives of gastric cancer patients, particularly those in their 20s and 30s. Early H. pylori eradication could prevent the progression to intestinal metaplasia and reduce the synergistic effect on gastric carcinogenesis in individuals with both H. pylori infection and a family history. Endoscopic surveillance is also expected to benefit individuals with a family history. Further large-scale, prospective studies are warranted to evaluate the cost-effectiveness and optimal time point for endoscopy in this population. Moreover, genome-wide association studies that incorporate environmental and dietary factors on a ‘big data’ basis will increase our understanding of the pathogenesis of gastric cancer.

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Helicobacter pylori genotypes and types of gastritis in first-degree relatives of gastric cancer patients

Cited by 10 publications

References 46 publications

Relevance of Helicobacter pylori vacA 3ʹ‐end Region Polymorphism to Gastric Cancer

Relevance of Helicobacter pylori vacA 3ʹ‐end Region Polymorphism to Gastric Cancer

Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk

Gastric cancer and family history

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