Helicobacter pylori gastritis is associated with increased expression of CD44 and CD44v9 on gastric epithelial cells

Fan, X. J.; Goggins, Michael; Long, Ai Sha; Fan, Xing‐Xing; Keeling, P. W. N.; Kelleher, Dermot

doi:10.1016/0016-5085(95)23033-5

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Microsatellite Instability1

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1997

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“…Overex pression of aberrant CD44 transcripts has been demonstrated in 100% of gastric tissue regardless of type, making CD44 abnormal transcripts an interesting prospect for gastric cancer diagnosis [112]. Gastric epithelial cells from patients with H. pylori gastritis were recently found to have increased expression of CD44 and of CD44v9 implying that H. pylori may be responsible for CD44 expression in gastric cancer [113]. Figure 4 summarizes the different genetic and molecular changes present in the two dif ferent types of gastric cancer.…”

Section: Microsatellite Instabilitymentioning

confidence: 99%

Molecular and Genetic Advances in Gastrointestinal Cancer: State of the Art

Younes

Johnson²

1997

Dig Dis

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There have been major advances in the understanding of the molecular and genetic basis of gastrointestinal malignancies. The introduction of new genetic techniques has generated considerable insight into the understanding of familial cancer as is the case with hereditary nonpolyposis colon cancer and familial adenomatous polyposis syndrome and in the understanding of premalignant conditions such as the various dysplasias and adenomas. This new information will be of tremendous help in the early detection, the prognostication, and hopefully the therapy of premalignant and malignant gastrointestinal diseases. This article will attempt to review all these advances with added emphasis on the clinically relevant issues.

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Section: Microsatellite Instabilitymentioning

confidence: 99%