Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia

Froehlich, Florian; Gonvers, J.-J.; Wietlisbach, Vincent; Burnand, Bernard; Hildebrand, Pius; Schneider, Cornelia; Saraga, E.; Beglinger, C.; Vader, John‐Paul

doi:10.1111/j.1572-0241.2001.04037.x

Cited by 53 publications

(16 citation statements)

References 34 publications

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“…At present, the causes of FD are believed to be multifactorial, and pathogenesis-based treatments, including administration of acid secretion inhibitors and prokinetics and eradication of Helicobacter pylori , have been used without success [4–6]. Therefore, many FD patients seek alternative and more effective treatments such as herbal prescriptions, nutritional supplements, acupuncture, or moxibustion [1, 7–9].…”

Section: Introductionmentioning

confidence: 99%

The Effects ofBanha-sasim-tangon Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial

Park

Han

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Introduction. Functional dyspepsia (FD) is highly prevalent, and no standard treatments exist for this condition. Herbal prescriptions are widely used to treat FD. In traditional Korean medicine, Banha-sasim-tang (BST) is a famous herbal prescription for dyspepsia. This study aimed to evaluate the efficacy of BST and to examine the relationship between gastric slow waves and dyspeptic symptoms. Materials and Methods. In total, 100 FD patients were recruited; BST or placebo was administered for 6 weeks. The gastrointestinal symptom scale, FD-related quality of life scale, and frequency or power variables regarding gastric slow waves were measured at 0, 6, and 14 weeks. Results. There were no significant differences in the overall dyspeptic symptoms or quality of life between the BST and placebo groups. However, early satiety was significantly improved in the BST group (P = 0.009, at 6 weeks by intention-to-treat analysis). Abnormal gastric dysrhythmias and power ratios were also significantly improved by BST. Conclusion. BST had no significant effects on FD. However, early satiety appeared to improve after BST administration. Electrogastrography may be a useful technique for assessing changes in gastric motility dysfunction after interventions for FD. Further investigation focused on specific symptoms or subtypes of FD is required.

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Section: Introductionmentioning

confidence: 99%

The Effects ofBanha-sasim-tangon Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial

Park

Han

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…In these patients we expected a greater chance of demonstrating an effect of H pylori therapy than in a general population of patients with functional dyspepsia. [2][3][4][5][6][7][8] The 52% cure rate of H pylori infection achieved using dual therapy with high dose omeprazole and amoxicillin was rather low. We chose this regimen because initial data suggested very high healing rates.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Helicobacter pylori in functional dyspepsia resistant to conventional management: a double blind randomised trial with a six month follow up

Koelz

2003

Gut

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“…The symptoms of FD are diverse, thus mechanism-focused therapies, such as acid secretion inhibitors, prokinetics, and H. pylori eradication, have been used with limited effects [8-10]. Therefore, many patients use alternative therapies, including herbal formulas, acupuncture treatments, and natural products, to treat FD [2,11-16].…”

Section: Introductionmentioning

confidence: 99%

Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial

Park

Ryu

Yeo

et al. 2010

Trials

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BackgroundFunctional dyspepsia (FD) is characterized by a high prevalence rate and no standard conventional treatments. Alternative therapies, such as herbal formulas, are widely used to treat FD. However, there are inadequate evidences regarding the safety and efficacy of these formulas. Moreover, the mechanisms by which herbal formulas act in the gastrointestinal tract are controversial. In traditional Korean medicine, Banha-sasim-tang has long been one of the most frequently prescribed herbal formulas for treating dyspepsia. The current study is designed to evaluate the efficacy and safety of Banha-sasim-tang for FD patients and to examine whether there will be a significant correlation between cutaneous electrogastrography recordings and dyspeptic symptoms in FD patients, and between changes in gastric myoelectrical activity and improvement in dyspeptic symptoms during Banha-sasim-tang administration.MethodsThis randomized, double-blind, placebo-controlled trial will be performed at two centers and will include a Banha-sasim-tang group and placebo group. Each group will consist of 50 FD patients. Six weeks of administration of Banha-sasim-tang or placebo will be conducted. During the subsequent 2 months, follow-up observations of primary and secondary outcomes will be performed. The primary outcomes are differences as measured on the gastrointestinal symptom scale, and the secondary outcomes are differences as measured on the visual analogue scale for dyspepsia and on the questionnaire for FD-related quality of life. All outcomes will be measured at baseline, at 2, 4, and 6 weeks of treatment, and at the 1 and 2 month follow-up. Cutaneous electrogastrography will be performed and assessed at baseline and at 6 weeks.DiscussionThis trial will provide evidence of the safety and efficacy of Banha-sasim-tang for the treatment for FD. Furthermore, based on the assessment of the relationship between cutaneous electrogastrography recordings and dyspeptic symptoms in this trial, the possibility of clinical applications of cutaneous electrogastrography in the treatment of FD will be elucidated.Trial RegistrationCurrent Controlled Trials (ISRCTN 51910678); Clinical Trials.gov Identifier: NCT00987805

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Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia

Abstract: This study did not demonstrate any substantial benefit of curing H. pylori infection in patients with nonulcer dyspepsia. The study adds further evidence that H. pylori is not the main pathogenetic or therapeutic target in these patients.

Cited by 53 publications

References 34 publications

The Effects ofBanha-sasim-tangon Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial

The Effects ofBanha-sasim-tangon Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial

Treatment of Helicobacter pylori in functional dyspepsia resistant to conventional management: a double blind randomised trial with a six month follow up

Banha-sasim-tang as an herbal formula for the treatment of functional dyspepsia: a randomized, double-blind, placebo-controlled, two-center trial

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