Helicobacter pylori eradication as exclusive treatment for limited-stage gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial

Ferreri, Andrés J.M.; Govi, Silvia; Raderer, Markus; Mulè, Antonino; Andriani, Alessandro; Caracciolo, Daniele; Devizzi, Liliana; Ilariucci, Fiorella; Luminari, Stefano; Viale, Edi; Müllauer, Leonhard; Dell’Oro, Stefania; Arcidiacono, Paolo Giorgio; Ponzoni, Maurilio; Patti, Caterina

doi:10.1182/blood-2012-06-438424

Cited by 55 publications

(49 citation statements)

References 6 publications

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“…Klebsiella pneumoniae and Proteus mirabilis cause colon cancer in Tbet À/À and Rag2 À/À ulcerative colitis (TRUC) mice through undetermined mechanisms (30). Furthermore, it is worth noting that MALT lymphoma and diffuse large B-cell lymphoma can often be treated solely by eradicating H. pylori, indicating that ongoing interactions with H. pylori are crucial for the survival of these tumors (34,35). Given this burgeoning role of bacteria in carcinogenesis and 2 previous reports that suggested that pseudomyxoma peritonei patients showed positive outcomes following antibiotic treatment (36,37), we have investigated the molecular mechanisms by which bacteria may influence pseudomyxoma peritonei development.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution

Semino–Mora

Testerman

Liu

et al. 2013

Clinical Cancer Research

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Purpose: Pseudomyxoma peritonei is an understudied cancer in which an appendiceal neoplasm invades the peritoneum and forms tumor foci on abdominal organs. Previous studies have shown that bacteria reside within pseudomyxoma peritonei tumors and mucin. Thus, we sought to analyze the effect of antibiotics on bacterial density and b-catenin expression within pseudomyxoma peritonei samples.Experimental Design: The study included 48 patients: 19 with disseminated peritoneal adenomucinosis (DPAM) and 29 with peritoneal mucinous carcinomatosis (PMCA). Fourteen patients were given antibiotics (30 mg lansoprazole, 1 g amoxicillin, and 500 mg clarithromycin) twice a day for 14 days. One week after completion of therapy, surgery was conducted and specimens were harvested for pathology, bacterial culture, ISH, and immunohistochemistry.Results: ISH showed the presence of bacteria in 83% of the patient samples, with a higher Helicobacter pylori density observed in PMCA versus DPAM. PMCA patients treated with antibiotics had a significantly lower bacterial density and decreased b-catenin levels in the cytoplasm, the cell nuclei, and mucin-associated cells. Although not significant, similar trends were observed in DPAM patients. Cell membrane b-catenin was significantly increased in both DPAM and PMCA patients receiving antibiotics.Conclusions: Bacteria play an important role in pseudomyxoma peritonei. Antibiotic treatment improved the histopathology of tissue, particularly in PMCA patients. In PMCA, antibiotics decreased bacterial density and were associated with a significant b-catenin decrease in the cytoplasm, cell nuclei, and mucin along with a small membrane increase. These results suggest that antibiotics offer potential protection against cell detachment, cellular invasion, and metastasis.

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Section: Discussionmentioning

confidence: 99%

Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution

Semino–Mora

Testerman

Liu

et al. 2013

Clinical Cancer Research

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“…51,52 Beyond specific pathogens, it has been shown that experiencing common community-acquired viral and bacterial infections early in life increases the risk for developing lymphoid malignancies later in life. Large epidemiological studies have shown clear associations between infections and monoclonal B-cell lymphocytosis (MBL) and CLL, non-Hodgkin lymphoma (NHL), and MM.…”

Section: Infection-induced Lymphoid Malignanciesmentioning

confidence: 99%

'Trained immunity: consequences for lymphoid malignancies

et al. 2016

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© Ferrata Storti Foundationhave no adaptive immune response, e.g., plants and invertebrates, but it also exists in humans, where it might be of special benefit in neonates that have yet to develop a mature adaptive immune repertoire.6 Importantly, 'training' of the innate immune system by the use of vaccination, resulting in increased immune activation, has been shown feasible. Hopefully these insights can be exploited in the near future for the design of new treatments for immunodeficiencies, infections and cancer.

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“…Nevertheless, there are studies showing promising results of HP eradication for DLBCL (MALT) (3)(4)(5)(6)(7). Furthermore, recent studies have also demonstrated the efficacy of HP eradication as an initial treatment for gastric pure DLBCL (8,9). We herein report a case of primary high-grade gastric B-cell lymphoma that was cured with HP eradication alone.…”

Section: Introductionmentioning

confidence: 86%

Gastric Diffuse Large B-cell Lymphoma Cured with <i>Helicobacter pylori</i> Eradication Regardless of Whether it Contains Features of MALT Lymphoma

et al. 2014

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A 66-year-old patient was diagnosed with primary gastric B-cell lymphoma. The pathological findings were consistent with diffuse large B-cell lymphoma (DLBCL); however, a small area showed features of mucosa-associated lymphoid tissue (MALT) lymphoma. Biopsy specimens were referred to two other pathologists, both of whom diagnosed the case as pure DLBCL, denying the area of MALT lymphoma. As the lymphoma was limited to the submucosal layer and the patient's general condition was excellent, eradication of Helicobacter pylori was selected as the initial treatment. The lymphoma completely disappeared three months after the eradication treatment, and complete remission has been maintained for nearly two years.

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Helicobacter pylori eradication as exclusive treatment for limited-stage gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial

Cited by 55 publications

References 6 publications

Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution

Antibiotic Treatment Decreases Microbial Burden Associated with Pseudomyxoma Peritonei and Affects β-Catenin Distribution

'Trained immunity: consequences for lymphoid malignancies

Gastric Diffuse Large B-cell Lymphoma Cured with <i>Helicobacter pylori</i> Eradication Regardless of Whether it Contains Features of MALT Lymphoma

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