Helicobacter pylori Colonization in Nasal Polyps

Konstantinou, Anastasia; Banos, George; Sakelaridis, Athanasios

doi:10.1055/s-2006-958591

Cited by 1 publication

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“…In the subgroup analysis, European studies as well as studies with IHC as diagnostic modality of active H. pylori infection were characterized by absence of heterogeneity, without loss of the statistical significance. This positive association is in accordance with the findings of the majority of performed cohort studies, supporting a role of H. pylori in the pathophysiology of nasal polyps [ 16 , 22 , 25 , 26 , 31 , 33 , 39 , 49 , 50 ].…”

Section: Discussionsupporting

confidence: 90%

“…Thus, the potential impact of H. pylori infection on nasal polyp development and management may have significant clinical impact. However, the available scientific evidence regarding the association of H. pylori infection and nasal polyps yields contradictory results [ 16 , 22 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ], and a systematic review with meta-analysis is lacking. The present study aimed to systematically collect and analyze good-quality existing clinical studies investigating the potential association between H. pylori infection and nasal polyps.…”

Section: Introductionmentioning

confidence: 99%

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Association between Helicobacter pylori Infection and Nasal Polyps: A Systematic Review and Meta-Analysis

et al. 2023

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Background: Helicobacter pylori (H. pylori) has definite or possible associations with multiple local and distant manifestations. H. pylori has been isolated from multiple sites throughout the body, including the nose. Clinical non-randomized studies with H. pylori report discrepant data regarding the association between H. pylori infection and nasal polyps. The aim of this first systematic review and meta-analysis was the assessment of the strength of the association between H. pylori infection and incidence of nasal polyps. Methods: We performed an electronic search in the three major medical databases, namely PubMed, EMBASE and Cochrane, to extract and analyze data as per PRISMA guidelines. Results: Out of 57 articles, 12 studies were graded as good quality for analysis. Male-to-female ratio was 2:1, and age ranged between 17–78 years. The cumulative pooled rate of H. pylori infection in the nasal polyp group was 32.3% (controls 17.8%). The comparison between the two groups revealed a more significant incidence of H. pylori infection among the nasal polyp group (OR 4.12), though with high heterogeneity I2 = 66%. Subgroup analysis demonstrated that in European studies, the prevalence of H. pylori infection among the nasal polyp group was significantly higher than in controls, yielding null heterogeneity. Subgroup analysis based on immunohistochemistry resulted in null heterogeneity with preserving a statistically significant difference in H. pylori infection prevalence between the groups. Conclusion: The present study revealed a positive association between H. pylori infection and nasal polyps.

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