Helicobacter pylori can be related to carotid intima-media thickness, epicardial adipose tissue thickness and serum neutrophil gelatinase-associated lipocalin (NGAL) levels

Karadağ, Zakir; Sehitoglu, T; Cüre, Medine Cumhur; Rakici, Halil; Ayvaz, Muhammed Ali; Bedir, Raouf; Kızılkaya, Bayram; Şahin, Osman; Cüre, Erkan

doi:10.4149/bll_2018_057

Cited by 8 publications

(19 citation statements)

References 39 publications

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“…In this survey, we investigated the relationship between Hp infection and CIMT in general subjects. Though numerous more recent publications concerning these associations are available 14 , 15 , our results were consistent with previous cohort studies that indicate no significant correlation between Hp infection and the average CIMT 13 .…”

Section: Discussionsupporting

confidence: 93%

Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population

Feng

Zhou

Luo

et al. 2018

Sci Rep

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The aim is to determine whether there is an independent association between Hp infection and carotid intima-media thickness (CIMT) in a cross-section observational study. Among of 14588 routine health check-up participants, 13770 subjects underwent the 13C-urea breath test (13C-UBT) and ultrasound measurement of CIMT. Traditional atherosclerotic risk factors were also recorded. The ratio of increased CIMT in Hp positive group (28.6%) was not significant difference compared with Hp negative group (29.7%) (p = 0.164). The HP infection rates was no significant difference between increased CIMT (38.4%) and non- increased CIMT (39.7%) patients. However, all the traditional atherosclerotic risk factors including age, gender, BMI, waistline, total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, free fatty acid, homocysteine, systolic and diastolic blood pressure, fasting plasma glucose and C reactive protein were different between increased CIMT and non- increased CIMT participants. The odds of Hp infection for CIMT risk (OR 0.948; 95% CI 0.879–1.022; P = 0.164) was not higher in binary logistic regression analysis even after adjustment for traditional risk factors (OR 1.118; 95% CI 0.958–1.306; P = 0.157). Our study found no evidence of association between CIMT and HP infection.

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Section: Discussionsupporting

confidence: 93%

Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population

Feng

Zhou

Luo

et al. 2018

Sci Rep

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“…Karadag et al studied CIMT, epicardial adipose tissue thickness, and biologic markers of inflammation in 90 dyspeptic patients, according to the presence of H pylori in gastric biopsies (Sydney classification) and found an independent association between gastric inflammation, H pylori infection, epicardial adipose tissue thickness, and CIMT. The latter was also independently associated with a high sensitivity C‐reactive protein level . A recent case‐control study performed by Kutluana et al showed that systemic arterial stiffness measured by pulse wave velocity was higher in patients with gastric intestinal metaplasia and atrophic gastritis, with lower B12 vitamin levels …”

Section: Cardiovascular Diseasesmentioning

confidence: 97%

Review:Helicobacter pyloriand extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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“…By reading the consensus of experts, 12 the data in Judaki (2017) 21 are not consistent with it, so it was also excluded. Overall, a total of 24 pieces of literature were finally included, of which 14 were about CIMT, [21][22][23][24][25][26][27][28][29][30][31][32][33][34] 2 were about FMD, 35,36 and 9 were about PWV. 23,[37][38][39][40][41][42][43][44] In addition, four studies have reported the relationship between Helicobacter pylori cytotoxin-associated gene-A (CagA)-positive strains and CIMT.…”

Section: Literature Search Processmentioning

confidence: 99%

Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

Shi

Dong

et al. 2021

Helicobacter

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Objective: In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima-media thickness (CIMT), flow-mediated dilation (FMD), or pulse wave velocity (PWV) are the most commonly used indicators to evaluate the progress of AS. So, we collected and evaluated these three indicators to provide evidence-based medicine for the clinic. Materials and methods:We included and evaluated studies on H. pylori infection and CIMT, FMD, or PWV from PubMed, Cochrane trials, and Embase databases before September 1, 2021, and language restrictions: English. Research types include crosssectional studies, cohort studies, and case-control studies. The MINORS scale was used to evaluate the quality of these studies. For all studies, we choose a randomeffects model and calculate the weighted mean difference (WMD) for analysis, and all our analyses use STATA software.Results: Meta-analysis shows that H. pylori infection can significantly increase CIMT (WMD = 0.059, 95% CI: 0.039, 0.079, p < 0.001). Based on subgroup analysis, we found that the relationship between the two is more significant in the young and middle-aged people younger than 60 years old and people without cardiovascular disease. In addition, we also found an association between H. pylori infection and FMD (WMD = −3.873, 95% CI: −5.684, −2.062, p < 0.001), but it is a pity that there are few literatures that meet the standards. Finally, We concluded that H. pylori infection can significantly increase PWV (WMD = 88.033, 95%CI: 67.297,108.768. I 2 = 99.63%, p < 0.001). In the subgroup analysis, we also found that this correlation is similar to CIMT, and it is more significant in the young and middle-aged population under 60 and those without cardiovascular disease. We also found in the sub-analysis that there was a significant increase in CIMT in CagA-positive individuals in H. pylori-infected patients (WMD = 0.16, 95%CI: 0.02, 0.29. p = 0.03). Conclusion:Helicobacter pylori infection can promote the process of AS, especially in people under the age of 60 and people without cardiovascular risk factors, and we hope that our meta-analysis can provide ideas for the early prevention of AS.

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Helicobacter pylori can be related to carotid intima-media thickness, epicardial adipose tissue thickness and serum neutrophil gelatinase-associated lipocalin (NGAL) levels

Abstract: HP-infection can lead to subclinical atherosclerosis via chronic inflammation. The higher the activity of HP infection, the higher the acceleration of atherosclerosis (Tab. 3, Fig. 2, Ref. 46). Text in PDF www.elis.sk.

Cited by 8 publications

References 39 publications

Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population

Helicobacter pylori infection is not related to increased carotid intima-media thickness in general population

Review:Helicobacter pyloriand extragastric diseases

Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis

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