Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer

Effective administration method of intravenous proton pump inhibitor: A novel testing using a BRAVO catheterless pH monitoring system

“…For factors influencing pH, only H. pylori was significant, which confirms previous reports that H. pylori-positive patients have higher suppression effects against gastric secretion (18,19). This study found that there were no differences in baseline pH between H. pylori-positive and -negative patients, but the % time of pH >4 and >6 for 48 h showed significant differences after the use of PPI.…”

Gastroesophageal reflux andHelicobacter pylori: a review

“…Verdu et al [13] showed that o meprazole produces a greater decrease in gastric acidity in subjects with Hp infection than in those who are Hp negative, and that omeprazole produces a smaller decrease in gastric acidity after Hp infection has been cured [ 14] . Similar findings have been obtained by Labenz et al [15] , who showed that in 17 FU patients, Hp eradication resulted in a marked decrease of the pHincreasing effect of omeprazole (24h median gastric pH: 5.5 vs 3.0, P<0.002) that was most pronounced during night time. Base line intragastric pH remained unchanged after eradication (median gastric pH: 1.…”

Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers

“…As the present study is on the effect on the first day after a single dose of PPIs, both RPZ and LPZ are considered to be influenced by CYP2C19 genotype status. Previous reports have indicated that H pylori infection of the gastric mucosa potentiates the effects of proton pump inhibitors [40,41] . Therefore, in the present study, the study subjects were all H pylori-negative CYP2C19 EMs.…”