Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa

Abstract

Aim: To investigate the relation between Helicobacter pylori associated gastroduodenal diseases and lymphoid tissue hyperplasia in the antral mucosa and to pursue its evolution after eradication of H pylori. Methods: Gastric antral biopsy specimens were obtained from 438 patients with H pylori positive gastroduodenal diseases (185 chronic gastritis, 69 gastric ulcer, and 184 duodenal ulcer) and 50 H pylori negative healthy controls. Lymphoid follicles and aggregates were counted and other pathological features were scored according to the updated Sydney system for classification of chronic gastritis. After a course of anti-H pylori treatment, biopsy specimens were obtained at four to six weeks, 12 months, and 24 months in the chronic gastritis patient group. Results: The total prevalence of lymphoid follicles and aggregates in the biopsies was 79.9% (350 of 438; 95% confidence intervals (CI), 0.76 to 0.84). The prevalence and density of lymphoid follicles and aggregates were significantly different in the various gastroduodenal diseases. The highest prevalence (89.9%; 95% CI, 0.83 to 0.97) and density (0.82) of lymphoid follicles and aggregates occurred in patients with gastric ulcers. The lowest prevalence of lymphoid follicles and aggregates was found in patients with chronic gastritis (74.6%; 95% CI, 0.68 to 0.81), and the lowest density of lymphoid follicles and aggregates (0.56) was seen in patients with duodenal ulcers. The prevalence and density of lymphoid follicles and aggregates correlated strongly with the activity and severity of gastric antral mucosal inflammation. The eradication of H pylori resulted in a decrease in the prevalence and density of lymphoid follicles and aggregates. Conclusion: The prevalence and density of lymphoid follicles and aggregates in gastric antral mucosal biopsies correlated closely with H pylori infection.

Histopathological analysis of chronic gastritis and correlation of pathological features with each other and with endoscopic findings

“…A higher incidence was seen in males with an M : F ratio of 2.1 : 1. Chen et al [7] also found a M : F ratio of 1.8 : 1.…”

Pseudolymphoma of the liver associated with primary biliary cirrhosis: A case report and review of literature

“…Nishijima et al [39] Nagano et al [40] 47 F 1 1.7 RLH Chronic thyroiditis, high titer of ANA 16 Pantanowitz et al [41] 69 F 2 1.7, 1.0 RLH Renal cell carcinoma 17 Okubo et al [2] 49 F 1 2 PL Sjögren's syndrome 18 Mori et al [42] 49…”

“…In other organs, several factors are thought to be associated with pseudolymphoma, i.e. EpsteinBarr virus (hard palate and oral mucosa [14] ), mechanical stimulation (ear [15] ), anticonvulsant drugs (skin [16] ) and Helicobacter pylori (H pylori) (stomach [17,18] ). Regarding the association of H pylori with gastric pseudolymphoma, successful treatment of the pseudolymphoma by eradication of H pylori has been reported [19] .…”

Histopathological Findings in Duodenal Biopsy of a Mexican Children Population with Gastritis by Helicobacter Pylori

“…The prevalence of DGM has been observed in 13% to 42% of children infected with Hp [5][6][7], however, there is no definitive correlation between the influence of chronic duodenitis and duodenal ulceration with the presence DGM [8]. DGM is common in the proximal duodenum and in persons over 7 years of age [9][10][11]. Duodenal ulcer prevalence increases with age, and its higher incidence is related with the chronic gastritis associated with Hp infection.…”

“…Because the prevalence of non-specific vs. Hp gastritis of cases reviewed at the service is approximately 3:1, 70 biopsy specimens with Hp infection (cases) and 220 with non-specific gastritis (controls) were included, although in the literature it has been reported to be 5:1 [8,10].…”