Helicobacter pylori as a pathogenic factor in Ménétrier's disease

Abstract

The cause of Ménétrier's disease is unknown, although various autoimmune, allergic, and infective causes have been postulated. This case report describes a 37-yr-old man with Ménétrier's disease associated with protein-losing enteropathy and Helicobacter pylori infection. Clinical, endoscopic, histological, and biochemical resolution occurred after treatment of Helicobacter pylori infection. The improvement observed in this case supports an etiological role for H. pylori infection in Ménétrier's disease.

Effect of Helicobacter pylori infection and its eradication on nutrition

“…In this study, the incidence of hypoproteinaemia was significantly higher in H. pylori ‐positive subjects than in H. pylori ‐negative subjects and was significantly decreased after the eradication of H. pylori . Recently, the hypoproteinaemia observed in Menetrier's disease, which is characterized by enlarged fold gastritis, has been reported to improve after the eradication of H. pylori infection 15–17 . As the enlarged folds of Menetrier's disease improve after the eradication of H. pylori , leakage of proteins from the gastric wall decreases, resulting in an improvement of serum protein levels.…”

“… 11 Obesity is a well‐known risk factor for the development of GERD 12–14 . Recently, hypoproteinaemia observed in Menetrier's disease has been reported to improve after the eradication of H. pylori infection 15–17 . However, few studies have been performed on the effect of H. pylori infection on nutrition.…”

Ménétrier’s disease, a premalignant condition, with coexisting advanced gastric cancer: A case report and review of the literature

“…While the development of MD is associated with the cytomegalovirus (CMV) infection in the case of infants, the cause of MD in adults remains unknown (3–5). Previous studies demonstrate the coexistence of MD with infections ( Helicobacter pylori , CMV, herpes simplex, human immunodeficiency virus [HIV], Mycoplasma pneumoniae ) (4,6–9) as well as non-specific inflammatory diseases (including ulcerative colitis) (10). However, the administration of targeted therapy in these disorders has not provided any benefits concerning the treatment of MD.…”

Protein-Losing Enteropathies

“…In addition, it is also possible that certain types of infections, such as that due to M. tuberculosis, Mycobacterium avium complex in acquired immunodeficiency syndrome (AIDS) (Ploddi et al, 1988;Ogawa et al, 2009), or various fungal infections (e.g., cryptococcal infection) could lead to blocked lymphatics and thus to secondary lymphangiectasia (Ogawa et al, 2009;Jabeen et al, 2012). Finally, as already noted, infection with H. pylori and CMV may lead to PLE because these infections lead to the development of Ménétrier's disease (Badov et al, 1998;Suter et al, 2000;Santolaria et al, 2004;Megged and Schlesinger, 2008).…”

“…Evidence for this comes from the fact that Ménétrier's disease has been associated with Helicobacter pylori infection and, in fact, in some cases treatment for this infection has led to resolution of the Ménétrier's disease (Badov et al, 1998;Santolaria et al, 2004). It should be noted, however, that given the high frequency of H. pylori infection in the general population, this association may occur purely by chance and in most instances there is little or no etiologic connection.…”