Helicobacter pylori and gastroesophageal reflux disease

Abstract

Background: The nature of the relationship between Helicobacter pylori and reflux oesophagitis is still not clear. To investigate the correlation between Helicobacter pylori infection and GERD taking into account endoscopic, pH-metric and histopathological data.

Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males

“…Indeed, some reports have demonstrated that H. pylori serostatus had an inverse association with GERD [11-13, 33, 35-38]. Other reports, however, contradict such a relationship [7,8,39]. The present study confirmed the significant protective role of H. pylori infection against EE.…”

“…Therefore, delineating the risk factors for GERD in an asymptomatic general population has great clinical implications. Disturbance of the antireflux barrier system, consisting of the lower esophageal sphincter, is the main mechanism involved in the pathophysiology of GERD [7]. Other underlying conditions, such as gastric acid production, intragastric pressure, and esophageal acid exposure, are also recognized as important factors [8][9][10][11] complicating the pathophysiological pathways involved in GERD.…”

Advantages of Moxifloxacin and Levofloxacin-based triple therapy for second-line treatments of persistent Helicobacter pylori infection: a meta analysis

“…Recently, several studies have suggested that H. pylori is also involved in the development of coronary heart disease [5], idiopathic thrombopenic purpura [6] and gastroesophageal refl ux disease [7]. H. pylori is a major cause of illness and death worldwide [4]; therefore, eradication of H. pylori has become an important consideration in the treatment of these diseases.…”

Characteristics of the Prevalence of Helicobacter Pylori in Some Rivers of Georgia Against the Background of the Infection Caused by H.Pylori

“…In developing countries H. pylori infection is much higher (90%). There are some virulence factors that enables H. pylori to be "implanted" and then to be persisted in host body (Grande M, 2008). Most of H. pylori strains develop VacA cytotoxin that has the ability to be vacuolated.…”