Helicobacter pylori and Bleeding Duodenal Ulcer: Prevalence of the Infection and Role of Non-steroidal Anti-inflammatory Drugs

Gisbert, Javier P.; González, Leticia; Pedro, A. de; Valbuena, Marta Ruiz de; Prieto, B.; Llorca, Ignacio; Briz, R.; Khorrami, Sam; García-Grávalos, R.; Pajares, J. M.

doi:10.1080/003655201300191978

Cited by 50 publications

(40 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike other studies [8], we did not find that age made any impact in UBT accuracy. Gender, ulcer location, or NSAID therapy also did not modify the results, as it has been previously reported [8,27].…”

Section: Discussionsupporting

confidence: 67%

“…This prevalence is somewhat higher than 70-72% obtained in two meta-analyses in a bleeding population [7,8] although similar to that obtained from some studies included in these meta-analyses (32-100%) and also very similar to that published in our country by some experts [8,27]. If we include for prevalence determination the 17 patients with no delayed UBT but who had an invasive test performed at endoscopy, prevalence drops to 77.4%; this fact could be explained by the high rate of false-negatives for invasive tests in the setting of a bleeding patient [7].…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Accuracy of Urea Breath Test Performed Immediately After Emergency Endoscopy in Peptic Ulcer Bleeding

et al. 2012

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 58%

Accuracy of Urea Breath Test Performed Immediately After Emergency Endoscopy in Peptic Ulcer Bleeding

et al. 2012

View full text Add to dashboard Cite

“…[5][6][7] Peptik ülser ve H. pylori ilişkisi açığa çıktıktan sonraki yıllarda, peptik ülserli hastalarda %100'e ulaşan oranda H. pylori pozitifliği saptanan çalışmalar yayınlanmıştır. [8][9][10][11] Bu bilgiler doğrultusun-da H. pylori'nin eradikasyonu peptik ülserin iyileşme oranlarını çok yüksek düzeye ulaştırmış ve tekrar etme oranını oldukça azaltmıştır. [12,13] Geçtiğimiz yıllarda duodenal ülseri olan hastalarda H. pylori pozitifliğinin %95'in üzerinde olması nedeniyle duodenal ülser saptanan tüm hastalara bakterinin varlığının araştırılmasına gerek duyulmadan ampirik olarak eradikasyon tedavisi verilmekteydi.…”

Section: Introductionunclassified

The frequency of ''Helicobacter pylori'' in patients diagnosed with peptic ulcer and gastritis

Emre¹,

Ahıshalı²,

Dolapcioglu³

et al. 2013

J Kartal TR

View full text Add to dashboard Cite

show abstract

“…Bleeding duodenal ulcer patients with neither H. pylori infection nor NSAID use are extremely rare (only 2%), which suggest that the pathogenesis of bleeding duodenal ulcer is similar to that of non-complicated duodenal ulcer disease" [8].…”

Section: Prevalence Of H Pylori In Bleeding Peptic Ulcer Diseasementioning

confidence: 99%

The Prevalence of Helicobacter pylori Infection in Bleeding and Non -Bleeding Gastric Ulcers: A Cross-Sectional Case-Control Study

Kgomo¹,

KS²

2016

J Bioanal Biomed

View full text Add to dashboard Cite

Introduction: Helicobacter pylori is a known and important cause of peptic ulcer disease, and can result in many different complications, both gastrointestinal and systemic. The gastric complications include upper gastrointestinal bleeding.The costs associated with testing and treatment of complications of H. pylori infection is also high, both in private and public setting. Studies in Iran showed high prevalence of H. pylori infection, with figures as high as 89.2% in the adult population. In South Africa, patients with bleeding gastric ulcers receive empirical eradication therapy, an expensive practice in a resource limited country like South Africa. It is for this reason that we conducted a case-control study to determine the difference in prevalence of H. pylori infection in bleeding and non-bleeding gastric ulcers. Aim:To determine the difference in prevalence of H. pylori infection in bleeding and non-bleeding gastric ulcers. Methods:In this prospective cross-sectional case-control study, a total of 173 patients who underwent upper endoscopy at Steve Biko Academic Hospital were recruited. All patients with gastric ulcer on upper endoscopy had antral mucosal biopsy taken and CLO test done on this specimen, in addition to the CLO test, the 42 with a history of upper gastrointestinal bleeding had additional biopsies send for histology for detection of H. pylori. The CLO tests were evaluated 24 h later and results documented as either positive or negative. Results:From the 173 patients enrolled, 131 patients were found to have no history of upper gastrointestinal bleeding, while 42 patients were found to be bleeding on upper endoscopy or had a recent history of bleeding. Of the total of 173, 134(77.5%) tested negative for H. pylori infection on CLO test and 39(22.5%) tested positive. Of the bleeding group, 7(16.7%) were CLO test positive and 35(83.3%) were negative. In the non-bleeding group of patients, 99(75.6%) were CLO test negative and 32(24.4%) tested positive. There was a 100% correlation between CLO test and histology. Of the bleeding group 35(83%) tested negative on both CLO test and histology and 7(16.7%) tested positive. Conclusion:The prevalence of H. pylori infection in this South African population with bleeding gastric ulcer was found to be lower than in patients with gastric ulcers that were not bleeding. This was, however not statistically significant (p value 0.404). To our knowledge there is no South African data for comparison with our study group.The sensitivity of CLO test was as high as histology. This finding suggests that CLO test can be used reliably in bleeding peptic ulcer.

show abstract

Helicobacter pylori and Bleeding Duodenal Ulcer: Prevalence of the Infection and Role of Non-steroidal Anti-inflammatory Drugs

Cited by 50 publications

References 43 publications

Accuracy of Urea Breath Test Performed Immediately After Emergency Endoscopy in Peptic Ulcer Bleeding

Accuracy of Urea Breath Test Performed Immediately After Emergency Endoscopy in Peptic Ulcer Bleeding

The frequency of ''Helicobacter pylori'' in patients diagnosed with peptic ulcer and gastritis

The Prevalence of Helicobacter pylori Infection in Bleeding and Non -Bleeding Gastric Ulcers: A Cross-Sectional Case-Control Study

Contact Info

Product

Resources

About