Helicobacter pylori and anemia: a community-based cross-sectional study among adults in Southern Brazil

Santos, Iná S.; Minten, Gicele C; Valle, Neiva C. J.; Tuerlinckx, Giovana Costa; Boccio, José; Barrado, Domingo Andrés; Silva, Alessandra Banaszeski da; Pereira, Guilherme Augusto Reissig

doi:10.1590/s0102-311x2009001200012

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Since parameters for sample size calculation were set to attend the aims of another research question to which the current study was linked [7], power of the study was calculated post hoc. The resulting sample of 865 women has a 85% power to detect relative risks ≥ 1.4 significant at alpha of 0.05, for exposures with a prevalence of 30% or greater and an expected frequency of disease in unexposed group of ≥ 30%.…”

Section: Resultsmentioning

confidence: 99%

Menstrual bleeding patterns: A community-based cross-sectional study among women aged 18-45 years in Southern Brazil

et al. 2011

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BackgroundPopulation variation in the duration and amount of menstrual bleeding has received little attention in the literature. This study describes these characteristics and investigates the distribution of self-perceived amount of menstrual bleeding according to socio-demographic, behavioral, and reproductive characteristics.MethodsA community-based cross-sectional study was conducted among 18-45 years old women users of the 31 primary health care (PHC) facilities in Pelotas city (Brazil). Interviews with structured questionnaire were carried out in the waiting rooms during two work shifts. Heaviness of menstrual bleeding was determined through the answer to the question: "Usually how much blood do you lose in every period?" Crude and adjusted analyses through Poisson regression took into account the aggregation per PHC facility.ResultsA total of 865 women were enrolled. Prevalence of heavy menstrual flow was 35.3% (95% CI 32.1-38.6%). In adjusted analyses, heavy menstrual bleeding was higher among the older, less educated and obese women, with higher number of pregnancies and who reported longer menstrual periods, extra-menstrual bleeding and clots in the flow. Use of hormonal contraceptive methods was protective against heavy menses.ConclusionHeavy menstrual bleeding is highly prevalent at the community level, and is associated with socio-demographic and anthropometric women's characteristics, as well as with duration of menstruation, extra-bleeding and presence of clots.

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Section: Resultsmentioning

confidence: 99%

Menstrual bleeding patterns: A community-based cross-sectional study among women aged 18-45 years in Southern Brazil

et al. 2011

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“…There are only a few studies on the prevalence of anemia in other population groups [20][21][22] . Studies of anemia in children and adolescents aged 6 to 18 years enrolled in public schools found prevalences of 3.6% in 2005 in Recife (PE) to 39.3% in 2008 in Maringá (PR) 21,22 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies of anemia in children and adolescents aged 6 to 18 years enrolled in public schools found prevalences of 3.6% in 2005 in Recife (PE) to 39.3% in 2008 in Maringá (PR) 21,22 . A study done in Pelotas (RS) found a prevalence of anemia in adults of 20.6% 20 .…”

Section: Discussionmentioning

confidence: 99%

Iron intake and its association with iron-deficiency anemia in agricultural workers' families from the Zona da Mata of Pernambuco, Brazil

et al. 2014

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OBJECTIVE: To verify the association between dietary iron intake and the occurrence of iron-deficiency anemia in agricultural workers' families from the municipality of Gameleira in the state of Pernambuco, Brazil. METHODS: The study population consisted of 46 harvesters' families, consisting of 225 individuals. The food intake of each individual was recorded on three different days by directly weighing the foods consumed. Hemoglobin was determined by fingerstick (HemoCue). This research used the probability of adequacy method to assess iron intake and the paired t test for comparing groups. The Spearman Mann-Whitney test estimated associations between the dietary variables and anemia. RESULTS: The prevalence of anemia was high in all ages groups and highest (67.6%) in children aged <5 years with a mean hemoglobin of 10.37 g/dL (±1.30 g/dL). Children aged <5 years had low percentage of iron intake adequacy (53.1%). Most of them consumed diets with low iron bioavailability (47.5%). Associations between the occurrence of anemia and dietary variables were significant for total iron (heme and nonheme), its bioavailabilities, and general meat intake. CONCLUSION: Inadequate dietary iron intake and inadequate intake of factors that facilitate iron absorption can be considered decisive for the occurrence of iron-deficiency anemia. Food insecurity occurs between family members, with some members being favored over others with regard to the intake of good dietary iron sources.

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“…The possible role of H. pylori infection in the development of hyposideremic anemia was recently investigated in five Latin America countries, Argentina, Bolivia, Brazil, Cuba, Mexico, and Venezuela [50], but no evidence was found to confirm the responsibility of such an infection. Brazilian individuals were investigated in greater depth [51] and, although no significant association was observed between anemia and H. pylori infection, a crude multilevel linear regression showed a reduction of 0.07 g/dL in those who were colonized, after adjusting for sex, skin color, income, age, and smoking. A major problem in those countries, however, is that only approximately 50% of anemia cases can be attributed to iron deficiency; other causes, which include malaria, hookworm infestation, schistosomiasis, inherited conditions such as thalassemia and dietary vitamin deficiency do not always emerge in the clinical history of individuals.…”

Section: Hematologic Diseasesmentioning

confidence: 99%

Extragastric Manifestations of Helicobacter pylori Infection

et al. 2010

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Since the discovery of Helicobacter pylori infection, several authors have investigated the immunological properties expressed by the bacterium in relation to the host. Those studies were expressly aimed at demonstrating how H. pylori may cause gastric mucosal damage and, at the same time, elude the immunological response evoked by the host. Data collected from those studies clearly showed that the immunological response caused by this bacterium is not only locally oriented but also systemically and that this immunological response may virtually cause local damage as well as influence the clinical course of other diseases, outside the stomach, thus opening the field of extragastric manifestations of H. pylori infection that we review in this manuscript. Cardiovascular DiseasesSome reviews have suggested a possible role of H. pylori infection in ischemic heart disease (IHD) [1][2][3][4][5][6][7]. Furthermore, there are also original studies conducted in this field, showing very interesting results. A study by Ayada et al. clearly showed that H. pylori promotes atherogenesis in heterozygous apoe (+ ⁄ )) ldlr (+ ⁄ )) mice. In particular, H. pylori infected and noninfected mice were fed a high fat diet from the age of 6 weeks; development of atherosclerotic lesions was observed in infected animals and correlated with an elevation of Th1-immune response against H. pylori heat shock protein 60. To confirm the plausibility of this hypothesis, H. pylori eradication significantly reduced the progression of atherosclerosis in infected mice [8]. A study by our group also showed a highly positive correlation between H. pylori and IHD. In particular, we performed a clinico-pathological study on patients with stable angina, unstable angina and normal controls and a meta-analysis in the attempt to shed new light on this complex issue. Anti-urease B and anti-CagA antibodies were assessed in all patients; moreover, coronary atherosclerotic plaque specimens were obtained by patients with stable and unstable angina and used for immunohistochemistry using anti-CagA antibodies. Interestingly, the anti-CagA but not anti-urease B antibody titer was significantly higher in patients with unstable angina compared to stable. Moreover, anti-CagA antibodies recognized antigens localized inside coronary atherosclerotic plaques. In the meta-analysis, seropositivity to CagA was significantly associated with the occurrence of acute coronary events with an adjusted odds ratio (OR) of 1.34 (95% confidence interval (CI), 1.15-1.58, p = .003). Thus, taken together, these findings suggest that in a subset of patients with unstable angina, an intense immune response against CagA-positive strains might act as a trigger for the precipitation of coronary instability via a molecular mimicry mechanism [9]. Another study by Jia et al.[10] reported a strong correlation between H. pylori infection and decreased levels of HDL cholesterol, which has been Keywords Idiopathic thrombopenic purpura, iron deficiency anemia, obesity, CagA, molecular mimicry.Reprint ...

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Helicobacter pylori and anemia: a community-based cross-sectional study among adults in Southern Brazil

Cited by 9 publications

References 16 publications

Menstrual bleeding patterns: A community-based cross-sectional study among women aged 18-45 years in Southern Brazil

Menstrual bleeding patterns: A community-based cross-sectional study among women aged 18-45 years in Southern Brazil

Iron intake and its association with iron-deficiency anemia in agricultural workers' families from the Zona da Mata of Pernambuco, Brazil

Extragastric Manifestations of Helicobacter pylori Infection

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