Helicobacter Pylori: A Review of Current Treatment Options in Clinical Practice

Roberts, Logan; Issa, Peter P.; Sinnathamby, Evan S.; Granier, Mallory A; Mayeux, Holly; Eubanks, Treniece N.; Malone, Kevin; Ahmadzadeh, Shahab; Cornett, Elyse M.; Shekoohi, Sahar; Kaye, Alan D.

doi:10.3390/life12122038

Cited by 3 publications

(4 citation statements)

References 87 publications

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“…At present, the current approach to triple or quadruple therapy involves combining PPI and amoxicillin with other antibiotics, like clarithromycin, erythromycin, metronidazole, and—more recently—rifabutin (Talicia). Nonetheless, employing antibiotics comes with numerous drawbacks: Side effects caused by excessive and high dose of antibiotics The present treatment regimen for H. pylori infection involves a high dosage (amoxicillin 1000 mg and clarithromycin 500 mg) administered two or three times a day over an extended period, typically 14 days [ 27 , 28 ]. Common antibiotic side effects encompass rash, dizziness, nausea, and diarrhea among others.…”

Section: Resultsmentioning

confidence: 99%

“…Side effects caused by excessive and high dose of antibiotics The present treatment regimen for H. pylori infection involves a high dosage (amoxicillin 1000 mg and clarithromycin 500 mg) administered two or three times a day over an extended period, typically 14 days [27,28]. Common antibiotic side effects encompass rash, dizziness, nausea, and diarrhea among others.…”

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confidence: 99%

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Artesunate Dry Emulsion Formulation Combined with Antibiotics for Treatment of Helicobacter pylori Infections: In Vitro/In Vivo Evaluation

Le-Tien,

Blemur,

Baltzis

2023

IJMS

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Helicobacter pylori is the primary pathogen responsible for causing gastroduodenal ulcers and stomach cancer. The standard treatment for H. pylori typically involves a combination of antibiotics and acid-reducing medications. However, the recurrence of ulcers is closely linked to the emergence of antibiotic resistance in H. pylori, necessitating the development of alternative drugs. This report focuses on the investigation of artesunate as a potential alternative to reduce antibiotic use and enhance effectiveness against H. pylori. Unfortunately, commercial artesunate is available in an acid form, which has poor solubility, especially in gastric acid fluid. The aim of this study is to utilize a water-soluble formulation of artesunate called dry emulsion formulation (ADEF) and combine it with amoxicillin to eradicate H. pylori. In vitro studies were conducted to evaluate the activity of ADEF against H. pylori and determine its inhibitory concentrations. In addition, pharmacokinetic parameters of orally administered ADEF and native artesunate were investigated in rats for in vivo studies. The results showed that when combined with amoxicillin and pantoprazole, ADEF exhibited effectiveness against H. pylori. It is worth noting that the solubility of ADEF in gastric acid appears to be a critical factor for achieving successful treatment. Consequently, ADEF could be considered a promising candidate for H. pylori therapy.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Artesunate Dry Emulsion Formulation Combined with Antibiotics for Treatment of Helicobacter pylori Infections: In Vitro/In Vivo Evaluation

Le-Tien,

Blemur,

Baltzis

2023

IJMS

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“…Уреазный дыхательный тест (УДТ) является чувствительным, что имеет большое значение в детской практике. Суть метода заключается в определении в выдыхаемом углекислом газе 13 С-меченной мочевины вследствие гидролиза уреазой Hp. Чувствительность метода составляет 95 и 93,5%, специфичность -96,6 и 97,7% соответственно.…”

Section: неинвазивные методыunclassified

“…Основной путь передачи Hp-инфекции -внутрисемейный оральнооральный или через предметы личной гигиены. Как правило, все члены семьи бывают поражены одним и тем же штаммом Hp [13]. При этом в большинстве случаев трансмиссия происходит от старшего возраста к младшему (в 60% случаев -от матери к ребёнку) в возрасте до 12 лет [14,15].…”

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Modern aspects of Helicobacter pylori infection

Yakovleva

Смирнова

Korsunskiy

2023

RPJ

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A systematic review of current data on the structure and functions of Helicobacter pylori (Hp), pathogenesis, diagnosis and treatment of Hp-infection is presented. The relevance of the topic of helicobacteriosis is due to the proven connection of this infection with chronic, widespread diseases of the digestive organs among the population. The review used materials from the databases including PubМed, Medline, EMBASE, Scopus, Google Scholar, RSCI. A systematic review based on studies with a high degree of evidence has shown significant progress in the diagnosis and treatment of Hp-infection in recent years in adults and children. Coordination of the scientific search for the regularities of the formation of Hp-associated forms of pathology, continuous improvement of diagnostic technologies and the search for new therapies, periodic well-organized international revisions of standard methods of Hp diagnosis and treatment contribute to the creation of effective methods of Hp eradication, preservation of the optimal composition of the microbiota of the gastrointestinal tract and prevention of antibiotic resistance. Of particular importance for the prevention of complications of Hp-infection are original diagnostic algorithms using specialized endoscopic and molecular technologies before and after Hp eradication with long-term follow-up and the determination of the leading factors correlating with a high risk of stomach cancer. The review indicates the emergence of potentially effective and promising areas for the diagnosis and treatment of Hp-infection, including genetic modification of the Hp genome to ensure its existence as a human symbiont and a significant reduction in its pathogenic properties. At the same time, sequencing of a new generation reveals mutations in Hp genes associated with its pathogenicity and antibiotic resistance, which contributes to the creation of new classes of drugs to increase the effectiveness of Hp eradication with a decrease in the proportion of antibiotics and an increase in pathogenetically significant inhibitors of its pathogenic factors for the prevention of side effects, a significant reduction in the empirical use of several antibiotics and increased compliance to treatment.

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Editorial: Helicobacter pylori and its mechanisms of antibiotic survival

Krzyżek

Puca²,

Grande³

2023

Front. Cell. Infect. Microbiol.

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Editorial on the Research TopicHelicobacter pylori and its mechanisms of antibiotic survival Helicobacter pylori is one of the most common human pathogens that, in the absence of therapeutic intervention, is able to remain in the gastric environment for an individual's entire life (Salama et al., 2013). Unfortunately, over time, situations in which treatment does not bring the desired effect are becoming more frequent (Boyanova et al., 2023). In the case of this bacterium, therapeutic failures are very often associated with the presence of genetic mutations at the target sites of antibiotics (Corteś et al., 2021; Roberts et al., 2022). It is increasingly postulated, however, that a variety of physiological processes may also affect the antibiotic tolerance or resistance of H. pylori, including biofilm formation Hou et al., 2022), morphological transformation (Gladyshev et al., 2020, and secretion of membrane vesicles (Jarzab et al., 2020). With reference to the above, the main purpose of this Research Topic was to draw attention to the importance of resistance and tolerance mechanisms promoting the survival of H. pylori under stressogenic conditions, especially antibiotic pressure.The basis for effectively counteracting antibiotic resistance is a thorough understanding of the factors responsible for the development and spreading of this phenomenon. In a comprehensive review, Liang et al. described strategies for the prevention and effective control of H. pylori infections. Attention was drawn to changes in treatment protocols over the last number of decades, including the switch from triple to quadruple therapies, extension of treatment length, and the use of new antibiotics or proton pump inhibitors. The limited effectiveness of these modifications and the need to search for alternative solutions, particularly the inclusion of probiotics in the treatment of H. pylori infections, were also highlighted.Referring to the urgency of applying novel procedures to treat H. pylori, in the original article by Wang et al., the effectiveness of liposomal linolenic acid (LipoLLA) against 30 clinical strains of H. pylori with different antibiotic resistance profiles was determined. This formulation was found to present a high bactericidal effect (MIC = 3.75-15 µg/mL), with activity dependent on both concentration and incubation time. It was observed that LipoLLA showed synergism or additivity with all four tested antibiotics (amoxicillin, clarithromycin, metronidazole, and levofloxacin), which was most likely related to the ability of LipoLLA to disrupt the continuity of bacterial cell structures and to stimulate Frontiers in Cellular and Infection Microbiology frontiersin.org 01

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Helicobacter Pylori: A Review of Current Treatment Options in Clinical Practice

Cited by 3 publications

References 87 publications

Artesunate Dry Emulsion Formulation Combined with Antibiotics for Treatment of Helicobacter pylori Infections: In Vitro/In Vivo Evaluation

Artesunate Dry Emulsion Formulation Combined with Antibiotics for Treatment of Helicobacter pylori Infections: In Vitro/In Vivo Evaluation

Modern aspects of Helicobacter pylori infection

Editorial: Helicobacter pylori and its mechanisms of antibiotic survival

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