Helicobacter, Inflammation, and Gastric Cancer

Sepulveda, Antonia R.

doi:10.1007/s40139-013-0009-8

Cited by 79 publications

(58 citation statements)

References 90 publications

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“…Importantly, there was a steady decline in the ASR, consistent to what have been reported elsewhere (Look et al, 2001;IARC, Globocan 2012;Atrkar-Roushan et al, 2013). H. pylori is a very important factor in the pathogenesis of gastric cancer and certain bacterial virulent characteristics virulent characteristics are very important (Cover et al, 2013;Sepulveda., 2013). Ever since its discovery H. pylori in the early 1980s, our understanding of the pathogenesis of gastric cancers has improved (Pandey et al, 2010).…”

Section: Discussionsupporting

confidence: 85%

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Chong

Telisinghe²,

Abdullah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Gastric cancer is the second most common gastrointestinal cancer and is more common in the East, compared to the West. This study assesses the trend of gastric cancers in Brunei Darussalam, a developing nation with a predominantly Malay population. Materials and Methods: The cancer registry from 1986 to 2012 maintained by the Department of Pathology, the only State Laboratory at the RIPAS Hospital, Ministry of Health, was reviewed and data extracted for analyses. The age standardised rate (ASR) and age specific incidence rate were calculated based on the projected population. Cancers diagnosed below 45 years were categorised as young gastric cancer. Results: Over the study period, there were a total of 551 cases of gastric cancer diagnosed. The most common type was adenocarcinoma (87.9%), followed by lymphoma (6.1%) and gastrointestinal stromal tumour (2.8%). The overall mean age at diagnosis was 61.9 years old (range 15 to 98) with an increasing trend observed, but this was not significant (ANOVA). There were differences in the mean age at diagnosis for the different races (p=0.003 for trend), but not the gender (p=0.105). Young gastric cancer accounted for 14.9%, being more common in women, and in Expatriate and Malay populations compared to the Chinese. There was a decrease in the ASR, from 17.3/100,000 in 1986-1990 to 12.5/100,000 in 2006-2010. Chinese had a higher overall ASR (20.2/100,000) compared to the Malays (11.8/100,000). The age specific rates were comparable between men and women until the age group 55-59 years when the rates started to diverge, becoming higher in men. Chinese men had higher rates then Malay men whereas, the rates were higher or comparable between the women until the age group >70 when the rate for Chinese women overtook their Malay counterpart. Conclusions: Our study showed that there is a declining trend in the incidence of gastric cancer and higher rates were observed in men and Chinese.

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Section: Discussionsupporting

confidence: 85%

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Chong

Telisinghe²,

Abdullah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) recognized the bacteria as carcinogen Class I in 1994. 1,2,3 In the last few years, this bacterium has not only been related to gastrointestinal diseases, but also to pathologies associated to bad absorption of nutrients like cardiovascular diseases, anemia, low birth weight babies, headache, and lipid metabolism alteration. 4 For years, it has been considered normal that women in the first three months of pregnancy show very uncomfortable gastric symptoms (such as morning sickness, heat, acidity, stomach ache, vomiting, headache, meteorism and flatulence) that may persist even during the whole pregnancy or with little reduction of the symptoms during this period.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women

Poveda

Carrillo

Monje

et al. 2014

Rev. Assoc. Med. Bras.

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Objective: the aim of this research was to determine the prevalence of Helicobacter pylori infection on Chilean pregnant women and its relationship with the appearance and severity of hyperemesis and dyspepsia. Methods: quantitative study of prevalence in a transversal cut with variable analysis. The sample was taken from 274 Chilean pregnant women from the Bío Bío province through vein puncture between June and December, 2005. Pregnant women were informed of this study, interviewed and signed an informed consent. The samples were processed using ImmunoComb II Helicobacter pylori IgG kit. Statistical analysis was performed by means of the Statistical Package for Social Sciences (SPSS) Program. Results: out of the total number of pregnant women, 68.6% showed infection by Helicobacter pylori. 79.6% of the total sample had symptoms of dyspepsia, and 72.5% of this group presented Helicobacter pylori infection. 12.4% showed pregnancy hyperemesis; among them, 79.4% were infected with Helicobacter pylori. 73.4% of the pregnant women that showed gastric discomfort during the first three months had Helicobacter pylori infection. 53.7% of them continued with gastric discomfort after the first three months; of those, 95.8% were infected. Helicobacter pylori infection was present only in 1.5% of pregnant women without gastric discomfort. Conclusion: both, gastric discomfort of pregnant women and the continuity of severe symptoms of dyspepsia and hyperemesis after the first three months of gestation are significantly correlated with Helicobacter pylori infection.

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“…Most stomach cancer is caused by H. pylori infection (3). The mechanism by which H. pylori induces stomach cancer potentially involves chronic inflammation or the action virulence factors such as CagA (4). Dietary factors including some foods with high sodium such as smoked foods, salted fish and pickled vegetables are associated with higher risk (5).…”

Section: Introductionmentioning

confidence: 99%

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

et al. 2014

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Abstract. MCM7 (mini-chromosome maintenance protein 7) is essential for the initiation of genomic replication as a component of the pre-replication complex. The present study aimed to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma (GAC). The MCM7 protein was upregulated in all 9 GAC cell lines. In 6 paired primary GACs, MCM7 was upregulated in tumor compared with the corresponding non-tumorous gastric tissues. In normal gastric epithelium tissue, MCM7 was strictly expressed in the proliferative compartment. MCM7 knockdown by siRNA in gastric cancer cell line AGS and NCI-N87 significantly suppressed cell proliferation, inhibited monolayer colony formation, reduced cell invasion and induced late apoptosis. Its nuclear expression correlated with advanced age and poorer disease specific survival in diffuse-type GACs. All the findings supported that MCM7 might play an oncogenic role in gastric tumorigenesis. It serves as a potential prognostic marker and therapeutic target in diffuse-type GACs.

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Helicobacter, Inflammation, and Gastric Cancer

Cited by 79 publications

References 90 publications

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women

MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function

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