Helicobacter - An Emerging New Zoonotic Pathogen

Kim, Okjin

doi:10.5772/37962

Cited by 3 publications

(3 citation statements)

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“…Epidemiological and clinical data regarding NHPH in feline stomachs are variable, but only few studies have determined the specific species present in these hosts [ 12 , 13 ]. According to the literature, the predominant feline gastric Helicobacter species are H. felis , H. bizzozeronii and H. heilmannii , and H. salomonis is less often detected [ 3 , 10 , 12 , 14 ]. Although its prevalence has not yet been established, H. baculiformis was also isolated from the stomach of a cat [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

Teixeira

Filipe²,

Cerqueira

et al. 2022

Veterinary Sciences

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In addition to Helicobacter pylori, many non-Helicobacter pylori Helicobacters (NHPH) are able to cause gastric disease in humans. Cats are a natural reservoir for many of these species. Accordingly, living in close and intimate contact with animals has been identified as a risk factor, and an important zoonotic significance has therefore been attributed to NHPH. To determine the prevalence and associated gastric histopathological changes of Helicobacter species, the gastric mucosa of 71 cats were evaluated. Only four presented normal histopathological mucosa with the absence of spiral-shaped organisms. Normal gastric mucosa and the presence of spiral-shaped bacteria were observed in 13 cats. The remaining animals presented histopathological changes representative of gastritis. Helicobacter species were detected in 53 cats (74.6%) by at least one detection method. None of the animals were positive for H. pylori or for H. ailurogastricus. Helicobacter heilmannii organisms were identified in 20 animals, predominantly in the body gastric region. Helicobacter salomonis was the second most prevalent species (57.1%), although it was mainly found in association with other NHPH. Helicobacter felis and H. bizzozeronii were less frequently detected. The great majority of the Helicobacter spp. PCR-positive animals presented normal features regarding fibrosis/mucosal atrophy, neutrophils, eosinophils, or other inflammatory cells and lymphofollicular hyperplasia. Given the controversy and the strong evidence of absence of significant histopathological alterations associated with the presence of Helicobacter spp. in cats, it is possible to hypothesize that these bacteria may be able to adapt to the feline gastric microenvironment or even to comprise part of the gastric microbiome of this animal species. Thus, prudency must be taken when prescribing an antibiotic therapy based solely on the presence of these bacteria in the feline stomach.

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Section: Introductionmentioning

confidence: 99%

Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

Teixeira

Filipe²,

Cerqueira

et al. 2022

Veterinary Sciences

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“…Discovery of the association of Helicobacter pylori with gastritis, peptic ulcers, and gastric neoplasia has led to fundamental changes in the understanding of gastric disease in humans [1,2,3]. Like H. pylori, other species of Helicobacter have been shown to colonize the stomach and cause disease in animals.…”

Section: Introductionmentioning

confidence: 99%

“…Gastric colonizers include H. felis, H. mustelae, H. acinonychis, H. bizzozeronii, H. heilmannii, H. salomonis, and a recently isolated novel Helicobacter sp. in dolphins [4,3]. H. felis is a gram-negative, spiral-shaped bacterium originally isolated from the stomachs of cats and dogs [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of assays to detect Helicobacter felis infection in cats

Hong¹,

Kim²

2015

J Biomed Res

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Recently, several companies have released H. pylori stool antigen (HpSA) test kits. However, there is little information about the usefulness of HpSA testing for Helicobacter felis, which is the major Helicobacter species in cats. The aim of the present study was to compare diagnostic methods for diagnosis of H. felis with HpSA tests and PCR assay using cat stools or gastric mucosa. Male cats (n=6) were infected with H. felis ATCC 49179 (1.0 × 10 9 CFU /cat) by intragastric inoculation two times at 3-day intervals, and stool specimens of cats were collected 1, 3, 5, 7, 14, and 21 days after infection for HpSA testing and H. felis-specific PCR. For the results, sensitivities of the HpSA test and PCR analysis were 50.0% and 83.3% respectively. Cats were sacrificed 21 days after H. felis inoculation, and gastric tissues were homogenized. All gastric biopsy specimens were positive based on a rapid urease test (RUT) (6/6, 100%) and PCR (6/6, 100%). Based on these results, the HpSA kit is useful and effective for monitoring H. felis infection using stool specimens. If an HpSA test could be made with H. felis antibodies in the future, its sensitivity could be increased further. Further, PCR assay could be successfully used to detect H. felis in stools. Application of this HpSA kit and PCR assay can be utilized as a non-invasive strategy to identify H. felis in cats.

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EnterohepaticHelicobacterspecies – clinical importance, host range, and zoonotic potential

Ochoa

Collado

2021

Critical Reviews in Microbiology

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Helicobacter - An Emerging New Zoonotic Pathogen

Cited by 3 publications

References 60 publications

Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence of Relevant Histopathological Alterations Reveals High Adaptation to the Host Gastric Niche

Evaluation of assays to detect Helicobacter felis infection in cats

EnterohepaticHelicobacterspecies – clinical importance, host range, and zoonotic potential

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