Helicascolide C, a new lactone from an Indonesian marine algicolous strain of Daldinia eschscholzii (Xylariaceae, Ascomycota)

Tarman, Kustiariyah; Palm, Gottfried J.; Porzel, Andrea; Merzweiler, Kurt; Arnold, Norbert; Wessjohann, Ludger A.; Unterseher, Martin; Lindequist, Ulrike

doi:10.1016/j.phytol.2011.10.006

Cited by 61 publications

(43 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, PCR-based ITS sequence analysis has been widely used to identify D. eschscholtzii (Chan et al, 2015; Hu et al, 2014; Tarman et al, 2012; Yuyama et al, 2013). Despite recent studies reporting limitations of the ITS region in distinguishing between the species complexes of Daldinia spp., this region has the broadest taxa covered in Daldinia (Stadler et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…It is characterized by colonies that are white to smoky gray with a slight olivaceous-tone, and by conidiogenous structures with a nodulisporium-like branching pattern (Ju, Rogers & Martin, 1997; Stadler et al, 2014). D. eschscholtzii grows preferentially on dead or decaying wood substrates, and is commonly isolated from dead woody plants such as dicotyledonous crop plants, trees, and occasionally, marine algae (Karnchanatat et al, 2007; Tarman et al, 2012; Zhang et al, 2008). …”

Section: Introductionmentioning

confidence: 99%

“…Compelling data in the last decade has demonstrated the presence of a wide array of secondary metabolites in this fungus, such as 1,1′-binaphthalene-4,4′-5,5′-tetrol (BNT) (a polyketide derived from 1,8-dihydroxynaphthalene biosynthesis), cytochalasins (metabolites of mixed polyketide/NRPS origin), concentricols (terpenoids derived from the acetate-mevanolate pathway), dalesconol A and B (polyketides), and helicascolide C (polyketides) (Fang et al, 2012; Stadler et al, 2001a; Stadler et al, 2001b; Tarman et al, 2012; Zhang et al, 2008; Zhang et al, 2011). Some of these secondary metabolites are precursors of biologically active medicinal compounds.…”

Section: Introductionmentioning

confidence: 99%

“…Some of these secondary metabolites are precursors of biologically active medicinal compounds. Dalesconol A and B have immunosuppressive activity (Zhang et al, 2008; Zhang et al, 2011) while helicascolide C exhibits antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum (Tarman et al, 2012). In a previous study, genome analysis of D. eschscholtzii clinical isolates showed that our isolates UM 1400 and UM 1020 are potentially rich in secondary metabolites (Chan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Identification and characterization ofDaldinia eschscholtziiisolated from skin scrapings, nails, and blood

Chan

Yew

et al. 2016

PeerJ

View full text Add to dashboard Cite

Background. Daldinia eschscholtzii is a filamentous wood-inhabiting endophyte commonly found in woody plants. Here, we report the identification and characterization of nine D. eschscholtzii isolates from skin scrapings, nail clippings, and blood. Methods. The nine isolates were identified based on colony morphology, light microscopy, and internal transcribed spacer (ITS)-based phylogeny. In vitro antifungal susceptibility of the fungal isolates was evaluated by the Etest to determine the minimum inhibitory concentration (MIC). Results. The nine isolates examined were confirmed as D. eschscholtzii. They exhibited typical features of Daldinia sp. on Sabouraud Dextrose Agar, with white felty colonies and black-gray coloration on the reverse side. Septate hyphae, branching conidiophore with conidiogenous cells budding from its terminus, and nodulisporium-like conidiophores were observed under the microscope. Phylogenetic analysis revealed that the nine isolates were clustered within the D. eschscholtzii species complex. All the isolates exhibited low MICs against azole agents (voriconazole, posaconazole, itraconazole, and ketoconazole), as well as amphotericin B, with MIC of less than 1 µg/ml. Discussion. Early and definitive identification of D. eschscholtzii is vital to reducing misuse of antimicrobial agents. Detailed morphological and molecular characterization as well as antifungal profiling of D. eschscholtzii provide the basis for future studies on its biology, pathogenicity, and medicinal potential.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification and characterization ofDaldinia eschscholtziiisolated from skin scrapings, nails, and blood

Chan

Yew

et al. 2016

PeerJ

View full text Add to dashboard Cite

show abstract

“…If the three-dimensional structures could not be downloaded, they were created using MarvinSketch with the minimization parameters of the MMFF94 force field and a strict optimization limit. Various marine fungi bioactive compounds, whether known specifically as anticancer or not, were included in the marine database, resulting in 268 structures that were downloaded from PubChem and ChemSpider or created using MarvinSketch [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Preparation Of the Marine Databasementioning

confidence: 99%

Database Compilation and Virtual Screening of Secondary Metabolites Derived From Marine Fungi as Epidermal Growth Factor Receptor Tyrosine Abstract Kinase Inhibitors

Watty

Syahdi

Yanuar

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Epidermal growth factor receptor (EGFR), a transmembrane protein with cytoplasmic kinase activity, transduces growth factor signaling from the extracellular space to the cell. EGFR downstream signaling increases proliferation and reduces apoptosis. Agents that are targeted at intracellular tyrosine kinase are tyrosine kinase inhibitor small molecules, which have a mechanism of action that affects adenosine triphosphate binding to the receptor. The exploration of bioactive compounds from marine materials, including marine fungi, has become a major interest lately for anticancer treatment. Methods:In this research, a database was created and in silico screening was conducted using AutoDock and Vina to obtain potential marine fungi bioactive compounds as EGFR-tyrosine kinase (EGFR-TK) inhibitors, which act as antiproliferative agents on tumor cell growth. Results:This research has concluded that the three marine fungi compounds with the lowest binding free energy, FU0015, FU0051, and FU0202, have great potential as inhibitors of EGFR-TK.Keywords: Marine fungi compounds, Epidermal growth factor receptor-tyrosine kinase, Virtual screening, AutoDock, Vina, Antiproliferative. INTRODUCTIONEpidermal growth factor receptor (EGFR) is an important target in the process of reducing tumor growth. More than 60% of non-small cell lung cancers express EGFR [1]. EGFR downstream signaling increases proliferation and angiogenesis and reduces apoptosis [2]. The overexpression of EGFR has been detected in the majority of human carcinomas [3].Tyrosine kinase inhibitors (TKIs) are one of four classes of anti-EGFR agents used for cancer therapy [4]. In 2015, gefitinib (one of the TKIs) was approved by the Food and Drug Administration (FDA) as an inhibitor of EGFR [5]. In addition to synthetic drugs, natural products have an important role in cancer therapy. Chemical compounds from natural products can be potential new medicines. The exploration of bioactive compounds from marine materials, including marine fungi, has become a major activity lately for anticancer treatment. Currently, there are anticancer compounds from marine fungal metabolites that have entered clinical trials. One of the alkaloid compounds, plinabulin, is a modified structure based on the (-)-phenylahistin metabolites of the terrestrial and marine fungi Aspergillus ustus [6]. As the development of microbiology technology increases in the future, the availability of microorganisms such as marine fungi will increase and the costs of production will be reduced. Therefore, bioactive compounds of marine fungi have the potential to be new drug compounds [7]. A database of active compounds was created to ease in silico and in vitro research further.In silico research can support conventional research (wet lab) that is relatively expensive and takes time [8]. AutoDock (Automatic Docking) is widely used to predict the complex of a biomolecular structure or to perform functional analysis and molecular design. AutoDock uses a grid-based method to rapidly evalu...

show abstract

Protecting‐Group‐Free Synthesis of Heterocycles

Aggarwal

Verma

2018

Protecting‐Group‐Free Organic Synthesis

View full text Add to dashboard Cite

Helicascolide C, a new lactone from an Indonesian marine algicolous strain of Daldinia eschscholzii (Xylariaceae, Ascomycota)

Cited by 61 publications

References 23 publications

Identification and characterization ofDaldinia eschscholtziiisolated from skin scrapings, nails, and blood

Identification and characterization ofDaldinia eschscholtziiisolated from skin scrapings, nails, and blood

Database Compilation and Virtual Screening of Secondary Metabolites Derived From Marine Fungi as Epidermal Growth Factor Receptor Tyrosine Abstract Kinase Inhibitors

Protecting‐Group‐Free Synthesis of Heterocycles

Contact Info

Product

Resources

About