Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis
Tim Schulte,
Antonio Chaves-Sanjuan,
Valentina Speranzini
et al.
Abstract:Systemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell clone. The high LC concentration in the blood leads to amyloid deposition at organ sites. Indeed, cryogenic electron microscopy (cryo-EM) has revealed unique amyloid folds for heart-derived fibrils taken from different patients. Here, we present the cryo-EM structure of heart-derived AL amyloid (AL59) from another patient with severe… Show more
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