Helical and Static-Port Tomotherapy Using the Newly-Developed Dynamic Jaws Technology for Lung Cancer

Manabe, Yoshihiko; Sugie, Chikao; Hayashi, Akira; Murai, Taro; Yanagi, Takeshi; Shibamoto, Yuta

doi:10.1016/j.ijrobp.2014.05.1848

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Meanwhile, it is essential to optimize equipment, a newly developed dynamic jaw technology (TomoEDGE) has been introduced. With this technology, radiation doses for the cranio-caudal edges of the target can be lowered by using narrower jaws around the edges (27).…”

Section: Discussionmentioning

confidence: 99%

Dosimetric comparison of helical tomotherapy and conventional Linac-based X-knife stereotactic body radiation therapy for primary lung cancer or pulmonary metastases

Li¹,

Yang²,

Liu³

et al. 2018

J. Thorac. Dis.

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Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods:We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016.Tumors were irradiated with 4-10 Gy per fraction in 5-15 fractions. Plans were compared according to PTV coverage and OARs sparing.Results: Significant differences between HT and X-knife were observed for both HI (P=0.003) and CI (P<0.001). The V5 (P=0.001), V10 (P=0.009), V20 (P=0.001), the mean lung dose (P=0.005) of total lung and maximum dose of the spinal cord (P=0.010) were significantly lower in the X-SBRT group than the HT-SBRT group. There were no significant differences for the V30 (P=0.075) and the mean heart dose (P=0.584) between the two groups.Conclusions: X-SBRT was dosimetrically superior to HT-SBRT, when applied in these tumors' maximum diameters <5 cm. As HT resulted in increased low-dose volume, it is essential to optimize the patient selection in order to avoid severe radiation pneumonitis in HT-SBRT.

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Section: Discussionmentioning

confidence: 99%

Dosimetric comparison of helical tomotherapy and conventional Linac-based X-knife stereotactic body radiation therapy for primary lung cancer or pulmonary metastases

Li¹,

Yang²,

Liu³

et al. 2018

J. Thorac. Dis.

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“…After August 2013, the newly developed dynamic jaw mode was used to reduce the craniocaudal dose spread. The dynamic jaw mode has been shown to be effective in the treatment of various lesion types …”

Section: Methodsmentioning

confidence: 99%

Helical tomotherapy for chemo‐refractory multiple liver metastases

et al. 2019

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Background Despite advances in chemotherapy, curing multiple liver metastases is quite rare. Even when response is obtained, regrowth of the tumors is almost inevitable. We aimed to evaluate the efficacy and adverse events of helical tomotherapy for chemo‐refractory multiple liver metastases. Methods Forty‐five patients with chemo‐refractory multiple (3‐10) liver metastases after standard systemic chemotherapy entered the single‐institutional prospective study. Liver metastases were the major disease; however, 31 also had uncontrolled primary lesions and/or other metastases. The prescribed dose was 55 Gy in 25 fractions. The median planning target volume (PTV) and normal liver volume (NLV) of first treatment were 128 cm3 and 1175 cm3, respectively. The median of V15Gy, V30Gy, and mean dose to NLV were 45%, 23%, and 19.4 Gy, respectively. Results Forty‐two patients (93%) completed the planned treatment. Median survival time (MST) for all patients was 8 months, and the 1‐year survival rate was 29%. The median local control (LC) period was 5 months and the 6‐month control rate of irradiated tumors was 33%. A ≥30% decrease in tumor markers was observed in 31%. The most common grade 3 toxicity was lymphocytopenia (40%), followed by fatigue (6%). Radiation‐induced liver disease (RILD) was not observed. Pancreatic cancer as the primary tumor, distant metastases outside the liver, low pretreatment neutrophil‐to‐lymphocyte ratio (NLR), and low pretreatment monocyte‐to‐lymphocyte ratio (MLR) were associated with poorer prognoses. Conclusions Helical tomotherapy for chemo‐refractory multiple liver metastases is a feasible and potentially effective treatment. Incorporating tomotherapy into the first‐line treatment in combination with systemic chemotherapy should be considered. Trial registration number CROG 12005.

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“…More suitable compromise between craniocaudal dose spread and treatment time may be the use of the recently developed dynamic jaw technology with dynamic adaptation of field width at cranial and caudal edges of a target. [11][12][13][14] This dynamic jaw mode of tomotherapy was recently introduced in our institution first in Japan. Figure 1 shows the difference between the dynamic jaw and conventional fixed jaw (constant field width) modes.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the Dynamic Jaw Mode in Helical Tomotherapy With Static Ports for Breast Cancer

Sugie

Manabe

Hayashi

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

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Helical and Static-Port Tomotherapy Using the Newly-Developed Dynamic Jaws Technology for Lung Cancer

Cited by 3 publications

References 17 publications

Dosimetric comparison of helical tomotherapy and conventional Linac-based X-knife stereotactic body radiation therapy for primary lung cancer or pulmonary metastases

Dosimetric comparison of helical tomotherapy and conventional Linac-based X-knife stereotactic body radiation therapy for primary lung cancer or pulmonary metastases

Helical tomotherapy for chemo‐refractory multiple liver metastases

Efficacy of the Dynamic Jaw Mode in Helical Tomotherapy With Static Ports for Breast Cancer

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