Heinz-Body Hemolytic Anemia from the Ingestion of Crude Oil: A Primary Toxic Effect in Marine Birds

Leighton, Frederick A.; Peakall, David B.; Butler, Ronald G.

doi:10.1126/science.6844918

Cited by 102 publications

(38 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were obtained in rats treated with gasoline vapors [19], in rats treated with Nigerian Bonny light crude oil [1,2], in rats treated with cypermethrin [20] and in rats treated with Doxorubicin [21]. It was found that treating rats with crude oil was associated with anemia of the haemolytic type [18,22]. Also, gasoline 80 inhalation may cause anemia where there was a decrease in Hb content in treated rats.…”

Section: Discussionsupporting

confidence: 72%

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Sedky¹

2015

J. Sci. Res.

View full text Add to dashboard Cite

The present work was designed to investigate the changes in some hematological, biochemical parameters and lipid profile as well as possible protective role of vitamins C and E against gasoline vapors induced toxicity in male rats. The present results showed that gasoline 80 vapors significantly decreased (p≤0.05) the concentration of total serum protein (TSP) and albumin concentrations and increased (p≤0.05) in serum activities of serum aminotransferases (ALT and AST) and alkaline phosphatase (ALP) compared to the control group. Also, exposure to gasoline 80 vapors induced significant decrease (p≤0.05) in hemoglobin concentration, red blood cell count (RBCs), packed cell volume (PCV) and high density lipoprotein cholesterol (HDL-C) compared to control group. On the other hand, exposure to gasoline 80 vapors resulted in significant increase (p≤0.05) in the levels of total cholesterol (TC), triglycerides (TGs), LDLcholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) relative to untreated experimental animals. However, concomitant treatment with gasoline vapors and administration of vitamins C and E exhibited a protective role on the observed toxic effect of gasoline vapors in male rats. The results of the present study indicated that toxic effects of gasoline vapors could be reduced by dietary supplementation of vitamins C and E.

show abstract

Section: Discussionsupporting

confidence: 72%

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Sedky¹

2015

J. Sci. Res.

View full text Add to dashboard Cite

show abstract

“…The majority of post-spill studies involve birds that have been subjected to cleaning and rehabilitation procedures in addition to oiling itself, and it can therefore be difficult to separate the effects due to the cleaning operations from those due to oil ingestion (Eppley & Rubega 1990, Anderson et al 1996, Sharp 1996. However, one primary toxic effect that occurs consistently as a result of crude oil ingestion in birds is haemolytic anaemia (Leighton et al 1983). As disturbance of red blood cell function can affect other tissues, many of the recorded physiological and behavioural effects on birds may be secondary responses to a primary dysfunction of erythrocytes (Leighton et al 1983).…”

Section: Introductionmentioning

confidence: 99%

“…However, one primary toxic effect that occurs consistently as a result of crude oil ingestion in birds is haemolytic anaemia (Leighton et al 1983). As disturbance of red blood cell function can affect other tissues, many of the recorded physiological and behavioural effects on birds may be secondary responses to a primary dysfunction of erythrocytes (Leighton et al 1983). Anaemia is relatively simple to detect in blood samples and thus provides a nondestructive means of detecting physiological effects of crude oil exposure in wild birds.…”

Section: Introductionmentioning

confidence: 99%

Sub-lethal effects of an oil pollution incident on breeding kittiwakes Rissa tridactyla

Walton¹,

Turner²,

Austin³

et al. 1997

Mar. Ecol. Prog. Ser.

View full text Add to dashboard Cite

fittiwakes from the colony closest to the site of the wreck of the 'Braer' oil tanker in Shetland, Scotland, in 1993 were studied in the breeding season following the spill. Sub-lethal effects of the spill on breeding kittiwakes were assessed by comparison with a n extensive data set collected at the same site (Sumburgh Head) during the 3 yr prior to the spill. Breeding performance in 1993 was very similar to that in 1992, with relatively good breeding success and short, frequent foraging trips. However, haematological data revealed a significant level of anaemia in the breeding kittiwakes at Sumburgh in 1993 compared to birds sampled in the same year at control colonies elsewhere in Scotland. The return rate of adults to the Sumburgh colony between 1992 and 1993 was exceptionally low, and nest-site and mate fidelity also appeared low. This was not a consequence of reduced survival, but was due to some adults not breeding in 1 or 2 yr following the spill, and subsequently returning to breed at the colony in later years. Such behavioural disruption may have considerable consequences for the dynamics and structure of the colony

show abstract

“…Hematological effects, specifically hemolytic anemia and oxidant damage to red blood cells (i.e., Heinz bodies), have been observed in birds that have ingested 10 ml/kg body weight of unweathered Prudhoe Bay crude oil [31]. This finding was not corroborated in our study, but this may be attributable to differences in the chemical composition of the weathered versus unweathered oil, quantity of oil ingested, or the route of ingestion (bolus injection vs. dietary consumption).…”

Section: Chronic and Reproductive Effectsmentioning

confidence: 99%

Effects of naturally weathered Exxon valdez crude oil on mallard reproduction

Stubblefield¹,

Hancock²,

Prince³

et al. 1995

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

-A one-generation reproductive toxicity study and a direct eggshell application toxicity study were conducted using the mallard (Anasplatyrhynchos) to assess the toxicity of naturally weathered North Slope crude oil (WEVC), obtained following the Exwon Valdez spill. In the reproductive study, birds were fed diets containing 0,200,2,000, and 20,000 mg of WEVC/kg diet. No significant differences ( p 5 0.05) in mortality, body weight, food consumption, reproductive parameters, or hatchling parameters were observed. Significant decreases in mean serum phosphorous, serum total protein, albumin, bilirubin, and calcium concentrations were observed in high-dose-group females; no differences were noted among males. Eggshell strength and thickness in the high-dose group were significantly reduced compared to controls. Trends toward increased liver weights and decreased spleen weights were observed in WEVC-treated birds. Applications of WEVC to developing eggs showed it to be less toxic than unweathered North Slope crude oil. Doses covering up to one-third of the shell area of developing mallard eggs (92 mg) resulted in no effects on developing embryos. Eggs treated with the control material, petrolatum, were adversely affected by applications covering approximately one-sixth of the eggshell (24 mg), suggesting inhibition of gas exchange. Neither material affected hatchling survival or growth.

show abstract

Heinz-Body Hemolytic Anemia from the Ingestion of Crude Oil: A Primary Toxic Effect in Marine Birds

Cited by 102 publications

References 14 publications

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Sub-lethal effects of an oil pollution incident on breeding kittiwakes Rissa tridactyla

Effects of naturally weathered Exxon valdez crude oil on mallard reproduction

Contact Info

Product

Resources

About