Heinz body anaemia in lambs with deficiencies of copper or selenium

Suttle, N. F.; Jones, Douglas; Woolliams, Carol; Woolliams, John

doi:10.1079/bjn19870122

Cited by 26 publications

(12 citation statements)

References 14 publications

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“…There is no consensus, however, that Cp-bound Cu is essential for this process, because plasma Cp activities have been identified which are not Cudependent and which presumably would be active during Cu deficiency (Prohaska 1983). Possibilities that Cu deficiency might impair mitochondrial binding of ferritin, NADH dehydrogenase activity, or even ferrochelatase activity should also be considered (Williams et al 1985). It has been shown recently that Cu deficiency can induce Heinz body formation and, therefore, the anemia in grazing Cu-deficient lambs may be partly hemolytic in origin (Suttle et al 1987). Other recent research (Johnson and Kramer 1987) suggests that Cu dehciency alters the mechanical properties of erythrocytes and decreases erythrocyte survivability due to splenic recognition of a modified membrane cytoskeleton.…”

Section: Canadian Journal Of Antmal Sciencementioning

confidence: 99%

Review of Copper Deficiency and Metabolism in Ruminants

Gooneratne¹,

Buckley²,

Christensen³

1989

Can. J. Anim. Sci.

141

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The importance of copper (Cu) for the proper functioning of many biological systems is well recognized. Copper deficiency significantly affects ruminant livestock production in large areas of Canada as well as many other parts of the world. Selected aspects of recent research into Cu deficiency in ruminants have been reviewed, including the biochemistry and physiology of Cu deficiency as well as the metabolism of Cu. Because of the wide occurrence of Cu deficiency in ruminants grazing in areas of high molybdenum (Mo) and/or sulfur (S), research on the mechanisms of interference in Cu metabolism has received wide attention. Similarities in the physiological effects of the combination of molybdate and sulfide (or sulfate) and of thiomolybdates in ruminants, strongly suggest that thiomolybdates are primarily involved in the induction of Cu deficiency. Thiomolybdates appear to induce Cu deficiency by (i) limiting Cu absorption, (ii) binding Cu in albumin, thus delaying Cu uptake by the liver, (iii) depleting liver Cu, (iv) altering liver Cu and Cu from other tissues to a less available form, (v) increasing biliary Cu excretion, (vi) limiting reabsorption of biliary Cu, (vii) increasing urinary Cu excretion, and (viii) increasing endogenous secretion of Cu. Copper, S and/or Mo have also been identified as factors in the etiology of polioencephalomalcia and abmosal ulcers but the mechanisms involved are not clear. Key words: Ruminants, copper, defiency, metabolism, sulfur

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Section: Canadian Journal Of Antmal Sciencementioning

confidence: 99%

Review of Copper Deficiency and Metabolism in Ruminants

Gooneratne¹,

Buckley²,

Christensen³

1989

Can. J. Anim. Sci.

141

View full text Add to dashboard Cite

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“…Common symptoms of copper shortage include anemia or anemization, depending on the severity and duration of the deficit. Hypochromic anemia reported in animals and associated with copper shortage constitutes a major challenge in a differential diagnosis, to distinguish from an iron deficit-induced disease (suttLe et al 1987). Prolonged copper shortage leads to lesions and deformations in bone tissue as well changes in the appearance and structure of animal hairs and wool (gehrke 1997a).…”

Section: Results and Disscusionmentioning

confidence: 99%

Effect of different forms of selenium on trace elements in the blood serum and liver tissue of lambs

Chałabis-Mazurek¹,

Wałkuska²

2014

J. Elem.

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The objective of the present research was to evaluate the dynamics of changes in the mineral content in blood serum and liver of lambs under dietary selenium supplementation. The study was conducted on 48 lambs assigned to three equal groups. The experiment started when the lambs were 5 weeks old, proceeded for 8 weeks and consisted of two stages. During the first, 4-week stage, the lambs were divided into three groups: group I-clinical control group, II-which received 0.2 mg Se/day in the form of enriched yeast, and III-which was fed 0.2 mg Se/day in the form of sodium selenite (POCH, Poland). During the second, 4-week stage, the lambs did not receive any supplements. Blood samples were taken after 1, 2, 3 and 4 weeks of the experiment. Liver samples were collected from slaughtered animals after 2, 4, 6 and 8 weeks since the onset of the experiment. Selenium supplementation significantly increased the Se concentration in the blood serum and liver of lambs. Selenium compounds significantly contributed to changes in the analyzed minerals, i.e. manganese, zinc, copper and iron. The results of this experiment suggest that selenium supplementation might lead to a decrease in levels other health-promoting elements such as Zn, Cu and Fe, and an increase in the Mn levels in the liver. Differences in the influence of organic and mineral forms of selenium on the Mn, Zn, and Cu content in the blood serum and liver were noticed. A significant decrease in the copper and iron content may induce symptoms of the deficiency of these trace elements in animals.

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“…Haemolysis may contribute to the development of anaemia. Signs of oxidative stress in the form of Heinz bodies have been reported in copper-deficient lambs (Suttle et al 1987). Significant deficiency of vitamins A and E was observed in the copper-deficient animals, while those supplemented with copper showed normal values.…”

Section: Discussionmentioning

confidence: 97%

Therapeutic management of copper deficiency in buffalo heifers: Impact on immune function

Sharma

Joshi²,

Das³

2007

Vet Res Commun

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To evaluate the magnitude of copper deficiency in Northern India and to examine the various haematobiochemicals, enzymes, vitamins and immune functions affected by copper deficiency, and to identify the parameters which can be of diagnostic importance in copper deficiency, a survey was conducted in 12 districts of Northern India. Significant deficiency of copper was observed in soil, fodder and serum samples of buffalo heifers. Fifty hypocuperaemic buffalo heifers were selected from these areas and were randomly divided into two groups, A and B. The heifers in group A were provided with mineral mixture containing copper sulphate and in group B without copper sulphate. Significant (p<0.01) improvement in serum ceruloplasmin level was observed within 30 days of treatment, while significant (p<0.01) improvement in monoamine oxidase and liver cytochrome oxidase was observed at the 60th day of treatment in group A animals. Significant improvement was observed in T(3) and T(4), in the animals of group A within 60 days of treatment. The values of vitamin A and E showed significant (p<0.01) improvement within 30 days of treatment. The phagocytic activity of neutrophils against Candida albicans significantly (p<0.01) improved in group A within 60 days of treatment. Similarly, significant improvement in superoxide dismutase activity in red blood cells was observed at the 30th day, and in total leukocytes and whole blood at the 60th day in group A animals. Significant improvement in liver copper level was observed at the 30th day of treatment, while in group B the liver copper was significantly (p<0.01) depleted at the 60th day of experimentation. Additional copper supplementation improved growth performance significantly in group A.

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Heinz body anaemia in lambs with deficiencies of copper or selenium

Cited by 26 publications

References 14 publications

Review of Copper Deficiency and Metabolism in Ruminants

Review of Copper Deficiency and Metabolism in Ruminants

Effect of different forms of selenium on trace elements in the blood serum and liver tissue of lambs

Therapeutic management of copper deficiency in buffalo heifers: Impact on immune function

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