Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity

Jia, Yan-Zhe; Yang, Yupei; Cheng, Shaowu; Cao, Liang; Xie, Qiankun; Wang, Mengyun; Li, Bin; Jian, Yuqing; Liu, Bin; Peng, Chao; Wang, Wei

doi:10.1016/j.phytochem.2021.112678

Cited by 18 publications

(6 citation statements)

References 39 publications

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“…This led to the isolation of 14 undescribed 2,2 0 -cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu S, with 27 previously described lignan analogues. The isolated compounds were evaluated for their hepatoprotective activity against APAPinduced toxicity in HepG-2 cells, heilaohuguosus A (25) and L (26), tiegusanin I (27) and kadsuphilol I (28) showed better hepatoprotective activities against APAP toxicity in HepG-2 cells with cell survival rates of 53.5 ± 1.7%, 55.2 ± 1.2%, 52.5 ± 2.4%, and 54.0 ± 2.2% (positive control bicyclol, 52.1 ± 1.3%) at 10 μM respectively (Jia et al, 2021). as well as the total bilirubin (TBIL), direct bilirubin (DBIL).…”

Section: Kadsura Coccineamentioning

confidence: 99%

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Thilagavathi

Begum

Varatharaj

et al. 2023

Phytotherapy Research

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Liver problems are a worldwide concern, and conventional medicinal therapies are ineffective. Hence, safeguarding the healthy liver is vital for good health and well‐being. Infections due to virus, immune problems, cancer, alcohol abuse, and an overdose of drugs are some of the causes of liver diseases. Antioxidants derived from medicinal plants and conventional dietary sources can protect the liver from damages caused by oxidative stress system and various chemicals. Plants and plant‐derived phytochemicals are appealing hepatoprotective agents since they have less side effects and still there is a lot of interest shown in using herbal tonics for treating liver disorders. This review therefore primarily focuses on newly discovered medicinal plants and compounds produced from plants that fall under the classifications of flavonoids, alkaloids, terpenoids, polyphenolics, sterols, anthocyanins, and saponin glycosides, all of which have the potential to be hepatoprotective. Hosta plantaginea, Ligusticum chuanxiong, Daniella oliveri, Garcinia mangostana, Solanum melongena, Vaccinium myrtillus, Picrorhiza kurroa, and Citrus medica are some potential plants having hepatoprotective effects. We conclude that these phytochemicals and the plant extracts listed above are used in the future to treat a variety of liver diseases, additional research is still needed to develop safer and more potent phytochemical drugs.

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Section: Kadsura Coccineamentioning

confidence: 99%

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Thilagavathi

Begum

Varatharaj

et al. 2023

Phytotherapy Research

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“…Folk medicine mostly uses its roots, vines, and fruits to treat stomach diseases, rheumatoid arthritis, bruises, swelling and pain, irregular menstruation, and so on [ 2 ]. Pharmacological studies showed that Kadsura coccinea has the effects of antitumor [ 1 ], antioxidation [ 3 ], liver protection [ 4 ], and inhibition of acetylcholinesterase [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Kadsura coccinea Lignan Metabolism Based on Metabolome and Transcriptome Analysis

Liang¹,

Li²,

Li³

et al. 2022

Journal of Oncology

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Kadsura coccinea is an important resource of traditional Chinese medicine. We find out the gene information of enzymes related to lignan biosynthesis and metabolism of Kadsura coccinea, so as to provide a scientific basis for the breeding of new varieties of Kadsura coccinea. In this paper, 2-year-old Kadsura coccinea from Hunan Kadsura coccinea provincial germplasm resource bank was used as the material and its root, stem, and leaf were analyzed by extensive targeted metabolomics combined with transcriptome sequencing. The results showed the following: (1) 51 lignans were detected by metabolome analysis, and the content of lignans in roots was higher than that in stems and leaves. The high content of lignans in roots, stems, and leaves includes ring-opening isolarch phenol-4-o-glucoside, narrow leaf schisandrin E, and schisandrin B. (2) After transcriptome sequencing, 13 classes of 137 Unigenes related to lignan biosynthesis pathway were retrieved. The analysis of differential genes in different parts showed that the overall expression amount and species of Kadsura coccinea lignan synthase gene in stems and leaves were closer than those in roots. CCoAOMT, C3H, and SIDR gene families are mainly expressed in roots and stems. (3) Metabolome combined with transcriptome analysis further screened these genes and obtained 11 genes of enzyme gene families such as HCT, DIR, COMT, CAD, SIDR, and PLR, which are highly correlated in lignan synthesis. Therefore, there are many lignans and their synthase-related genes in Kadsura coccinea roots, stems, and leaves, but the content and expression of different lignans and their synthase-related genes are quite different in each part. In this study, the gene information of the Kadsura coccinea lignan biosynthesis enzyme was obtained for the first time, which laid a good foundation for the cloning and molecular breeding of the key enzyme gene of lignan biosynthesis.

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“…In particular, lignans [ 2 , 3 , 4 , 5 , 6 ] and triterpenoids [ 7 , 8 , 9 , 10 , 11 , 12 ] from this plant have been received considerable attention. In previous studies, the compounds of K. coccinea have been reported with various activities, including the inhibition of nitric oxide production [ 2 , 13 ], antioxidant [ 14 , 15 ], anti-HIV [ 16 ], anti-inflammatory [ 17 ], hepatoprotective [ 18 ], acetylcholinesterase and butyrylcholinesterase inhibitory activities [ 15 , 19 , 20 ], and other pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea

Zhao

Zhu

2021

Molecules

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The chemical composition and biological activities of the essential oils from the leaves, stems, and roots of Kadsura coccinea (K. coccinea) were investigated. The essential oils were extracted by hydro distillation and analyzed by gas chromatography mass spectrometry (GC-MS) and gas chromatography with flame ionization detector (GC-FID). Antioxidant activities of the essential oils were examined with DPPH radical scavenging assay, ABTS cation radical scavenging assay, and ferric reducing antioxidant power assay. Antimicrobial activities were evaluated by determining minimum inhibitory concentrations (MIC) and minimum microbiocidal concentrations (MMC). Acetylcholinesterase and butyrylcholinesterase inhibitory activity of the essential oils were also tested. A total of 46, 44, and 47 components were identified in the leaf, stem, and root oils, representing 95.66%, 97.35%, and 92.72% of total composition, respectively. The major compounds of three essential oils were α-pinene (16.60–42.02%), β-pinene (10.03–18.82%), camphene (1.56–10.95%), borneol (0.50–7.71%), δ-cadinene (1.52–7.06%), and β-elemene (1.86–4.45%). The essential oils were found to have weak antioxidant activities and cholinesterase inhibition activities. The essential oils showed more inhibitory effects against Staphylococcus aureus (S. aureus) than those of other strains. The highest antimicrobial activity was observed in the root oil against S. aureus, with MIC of 0.78 mg/mL. Therefore, K. coccinea essential oils might be considered as a natural antibacterial agent against S. aureus with potential application in food and pharmaceutical industries.

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Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity

Cited by 18 publications

References 39 publications

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Kadsura coccinea Lignan Metabolism Based on Metabolome and Transcriptome Analysis

Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea

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